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“Protein Intrinsic Disorder: Cause and Consequence”
Meeting Agenda
Petit Biotechnology Building (IBB),Suddath Seminar Room 1128
Georgia Institute of Technology, 315 Ferst Drive NW, Atlanta, GA
Thursday, February 27, 2025
| 11:00 - 11:45 a.m. | 2025 Suddath Award Presentation “Enabling Technologies for Next-generation Cell-free Diagnostics” | Alexandra Patterson, Ph.D. Candidate, Mark Styczynski, Advisor |
| 11:45 - 12:00 p.m. | Presentation of 2025 Suddath Award | Brant and Vincent Suddath |
Official Opening of the 2025 Suddath Symposium | ||
| 1:00 p.m. | Opening Remarks | Nick Hud, IBB Associate Director, J.C. Gumbart, Matthew Torres - Symposium Co-Chairs |
| Session I - Session Chair, Dustin Huard | ||
| 1:05 p.m. | "Sequence-to-Ensemble: Fast and Accurate Generative Modelling of IDR Conformational Ensembles" | Alex Holehouse, Washington University, St. Louis |
| 1:45 p.m. | "Conformational Dynamics in Early Protein Evolution" | Lynn Kamerlin, Georgia Tech |
| 2:25 p.m. | Break | |
| Session II - Session Chair, Katie Kuo | ||
| 2:45 p.m | "From Polyfunctionality to Multipathogenicity with Intrinsic Disorder" | Vladimir Uversky, University of South Florida |
| 3:25 p.m. | "Accessing Phosphorylation-induced Conditional Protein Folds Through Generative Machine Learning” | Matthew Torres, Georgia Tech |
| 4:05 p.m. | "Liquid-liquid Phase Separation, Amyloid Oligomer Formation, and Heterotypic Amyloid" | Anant Paravastu, Georgia Tech |
| 4:45 p.m | Adjourn | |
Friday, February 28, 2025
| 8:30 a.m. | Breakfast, Nerem Atrium | |
| Session III - Session Chair, Tarunya Sudarshan | ||
| 9:10 a.m. | "Liquid-Liquid Phase Separation and Fibrillization of the Tau Protein" | Joan-Emma Shea, University of California, Santa Barbara |
| 9:50 a.m. | "From Disorder to New Order: IDRs, LLPS and Prions" | Yury Chernoff, Georgia Tech |
| 10:30 a.m. | Break | |
| 11:00 a.m. | “Pathogenic Aggregation of Glaucoma-associated Myocilin” | Raquel Lieberman, Georgia Tech |
| 11:40 a.m. | Poster Session and Lunch, Nerem Atrium | |
| Session IV - Session Chair, Vardhan Satalkar | ||
| 1:30 p.m | "Uncovering Molecular Driving Forces to Macroscopic Properties in Biomolecular Condensates Through Multiscale Computational Models" | Jeetain Mittal, Texas A&M University |
| 2:10 p.m. | "Finding Functional Properties of Complex Condensates at the Synapse" | Nathan McDonald, Georgia Tech |
| 2:50 p.m. | Break | |
| 3:10 p.m. | "From Physics to Biology and Back Again: How Physical Understanding of Condensate Properties can Explain Biological Function and Disease Processes" | Tanja Mittag, St. Jude Children's Research Hospital |
| 3:50 p.m. | “Programmability and High-fidelity Probing of Intracellular Condensates Driven by Disordered Proteins” | Felipe Quiroz, Emory University/Georgia Tech |
| 4:30 p.m. | Closing Remarks | |
| 4:40 p.m. | Adjourn | |
