“Protein Intrinsic Disorder: Cause and Consequence”

February 27-28, 2025
Georgia Tech

Petit Biotechnology Building (IBB)
Suddath Seminar Room 1128
315 Ferst Drive NW, Atlanta, GA

Emerging evidence has highlighted the fact that over half of protein content of living cells exists in a non-structured (i.e. intrinsically disordered) state that deviates significantly from our typical view of proteins as collections of ordered structures. Such disordered protein structures have not been widely studied until recently and represent a frontier for new discovery in protein science. With the advent of new tools in AI and machine learning, and a growing realization of the connection between protein disorder, dynamic protein modification, protein folding, and molecular assemblies (e.g. amyloids or phase-separated protein structures), the field has seen considerable growth in recent years and shares the promise of new discoveries in protein design, control, and fundamental biological understanding. This symposium will host six internationally recognized external speakers and six Georgia Tech / Emory University faculty with research foci in three major areas of interest, including: LLPS/Molecular Compartmentalization, Disorder/Order Transitions, and Protein Misfolding/Amyloids.

The Suddath Symposium is held annually to celebrate the life and contribution of F.L. "Bud" Suddath by discussing the latest developments in bioengineering and bioscience. The speakers include leading researchers from around the world, and the research topic changes each year. This highly-interactive symposium has been taking place for over 30 years and is supported by the Institute for Bioengineering and Bioscience at Georgia Tech.

Symposium Co-chairs:

• James "J.C." Gumbart
• Matthew Torres