Hyojung Choo

Hyojung Choo 's profile picture
hyojung.choo@emory.edu
Assistant Professor
Phone
404-727-3727
Office
542 Whitehead Research Building, Emory School of Medicine
Additional Research

"Craniofacial muscles are essential muscles for normal daily life. They are involved in facial expressions (facial muscles), blinking and eye movement (eye muscles), as well as speaking and eating (tongue and pharyngeal muscles). Interestingly, craniofacial muscles have differential susceptibility to several muscular dystrophies. For example, craniofacial muscles are the most affected muscles in oculopharyngeal muscular dystrophy but the least affected muscles in Duchenne muscular dystrophy. Among craniofacial muscles, dysfunction of tongue and pharyngeal muscles could cause an eating disability, called dysphagia, afflicts almost 15 million Americans including elderly, neuronal (Parkinson's disease and bulbar-onset amyotrophic lateral sclerosis) and muscular disease (oculopharyngeal muscular dystrophy) patients. However, no cure or therapeutic treatment exists for dysphagia caused by muscular dystrophy. Elucidation of the mechanism(s) behind these differing susceptibilities of craniofacial muscles could lead to development of potential therapeutics targeted to specific skeletal muscles involved in particular types of muscular dystrophy. The mechanisms of skeletal muscles are of interest here because skeletal muscle cells are multinucleated cells. Typically, skeletal muscle cells contain hundreds of nuclei in a single cell since they are generated by fusion of muscle precursor cells during development or by fusion of muscle specific stem cells, called satellite cells, in adult skeletal muscles. However, it is unclear how skeletal muscle cells regulate the quantity and quality of these multi-nuclei. Since craniofacial skeletal muscles, such as extraocular and pharyngeal muscles, have active satellite cell fusion in comparison to limb muscles, they are therefore suitable models to study myonuclear addition and homeostasis."

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Bilal Haider

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bilal.haider@bme.gatech.edu
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Bilal Haider is an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. He received B.S. and M.S. degrees from the University of Illinois Urbana-Champaign and M.Phil. and Ph.D. degrees from Yale University. He joined the faculty at Georgia Tech after completing postdoctoral training at University College London.

Haider’s research measures, manipulates and deciphers neural circuit activity underlying normal and impaired visual perception, providing new insights into how the brain processes information and orchestrates behavioral actions.

Haider has received several prestigious awards, including from the Whitehall Foundation, Simons Foundation and the Alfred P. Sloan Foundation. His work has been published in leading journals, including NatureNature NeuroscienceNature Communications and Neuron.

Assistant Professor
Phone
404-385-4935
Office
UAW 3104
Additional Research
Bilal Haider’s research goal is to measure, manipulate, and decipher neural circuit activity underlying visual perception and visual attention. He received B.S. and M.S. degrees from the University of Illinois Urbana-Champaign, M. Phil. and Ph.D. degrees from Yale University, and postdoctoral training at University College London. His lab uses advanced electrical, optical, and behavioral technologies to reveal insights into the inner workings of the brain in real-time and with unprecedented resolution. By discovering mechanisms  of information processing in neural circuits, his research provides critical steps towards understanding impairments in many neurological disorders such as schizophrenia, epilepsy, and autism spectrum disorder. 
Research Focus Areas
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https://scholar.google.com/citations?user=P5IKL5UAAAAJ&hl=en
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Ingeborg Schmidt-Krey

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ingeborg.schmidt-krey@biosci.gatech.edu

Ingeborg Schmidt-Krey is an associate professor in the School of Biological Sciences at Georgia Tech. Her research interests lie in the structure and function of eukaryotic membrane proteins, two-dimensional crystallization, electron crystallography, single particle analysis, and electron cryo-microscopy (cryo-EM).

Associate Professor
Phone
404-385-0286
Office
Cherry Emerson A118
Additional Research
Eukaryotic membrane proteins comprise approximately 60% of all drug targets and are consequently immensely important for biomedical research. Despite their importance, only few could thus far be studied at the structural level. My research focuses on the crystallization, structure and function of eukaryotic membrane proteins. Electron crystallography is the main tool employed to study these proteins in my laboratory. Initially, this involves testing of conditions for growing two-dimensional (2D) crystals, usually by reconstituting the detergent-solubilized membrane protein into a bilayer. Once crystallization parameters have been identified by electron microscopy of negatively stained samples, electron cryo-microscopy is employed to collect high-resolution data. The structure is then obtained by image processing. The approach of 2D crystallization and electron crystallography is particularly suitable for highly fragile membrane proteins such as many eukaryotic ones. Reconstitution ensures an environment that is close to the native one, the detergent is removed, and functional studies are relatively easily undertaken. Experimental phases are obtained due to the fact that images are collected. In some instances the image amplitudes can be substituted with electron diffraction amplitudes. Although electron crystallographic methods are well developed, little is known about the factors important in 2D crystallization, and screening protocols as for 3D crystallization do not exist. An important aspect of my research interests aims at developing screening methods and strategies for 2D crystallization and at understanding the underlying mechanisms.
Google Scholar
https://scholar.google.com/scholar?hl=en&q=Ingeborg+Schmidt-Krey&btnG=&as_sdt=1,11&as_sdtp=
http://biosciences.gatech.edu/people/ingeborg-schmidt-krey

Christopher Rozell

Christopher Rozell's profile picture
crozell@gatech.edu
SIPLab
Professor; School of Electrical and Computer Engineering
Director; Sensory Information Processing Lab
Phone
404.385.7671
Office
Centergy One 5218
Additional Research

Biological and computational vision Theoretical and computational neuroscience High-dimensional data analysis Distributed computing in novel architectures Applications in imaging, remote sensing, and biotechnology Dr. Rozell's research interests focus on the intersection of computational neuroscience and signal processing. One branch of this work aims to understand how neural systems organize and process sensory information, drawing on modern engineering ideas to develop improved data analysis tools and theoretical models. The other branch of this work uses recent insight into neural information processing to develop new and efficient approaches to difficult data analysis tasks.

Google Scholar
http://scholar.google.com/citations?user=JHuo2D0AAAAJ&hl=en&oi=ao
ECE Profile Page

Munmun De Choudhury

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munmund@gatech.edu
http://www.munmund.net/

Munmun De Choudhury is a Professor at the School of Interactive Computing in Georgia Institute of Technology. She is renowned for her groundbreaking contributions to the fields of computational social science, human-computer interaction, and digital mental health. Through fostering interdisciplinary collaborations across academia, industry, and public health sectors. De Choudhury and her collaborators have contributed significantly to advancing the development of computational techniques for early detection and intervention in mental health, as well as in unpacking how social media use benefits or harms mental well-being. De Choudhury's contributions have been recognized worldwide, with significant scholarly impact evidenced by numerous awards like induction into the SIGCHI Academy and the 2023 SIGCHI Societal Impact Award. Beyond her academic achievements, She is a proactive community leader, a persistent contributor to policy-framing and advocacy initiatives, and is frequently sought for expert advice to governments, and national and international media.

 

Professor in the School of Interactive Computing; Director of Social Dynamics and Well-Being Laboratory; Co-Lead of Children's Healthcare of Atlanta Pediatric Technology Center at Georgia Tech's Patient-Centered Care Delivery
Phone
4043858603
Additional Research

Social Media; Social Computing; Computational Social Science; Mental Health; Natural Language

Eva Dyer

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evadyer@gatech.edu
Website

Dyer’s research interests lie at the intersection of machine learning, optimization, and neuroscience. Her lab develops computational methods for discovering principles that govern the organization and structure of the brain, as well as methods for integrating multi-modal datasets to reveal the link between neural structure and function.

Assistant Professor
Phone
404-894-4738
Office
UAW 3108
Additional Research

Eva Dyer’s research combines machine learning and neuroscience to understand the brain, its function, and how neural circuits are shaped by disease. Her lab, the Neural Data Science (NerDS) Lab, develops new tools and frameworks for interpreting complex neuroscience datasets and building machine intelligence architectures inspired by the brain. Through a synergistic combination of methods and insights from both fields, Dr. Dyer aims to advance the understanding of neural computation and develop new abstractions of biological organization and function that can be used to create more flexible AI systems.

Research Focus Areas
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https://scholar.google.com/citations?user=Sb_jcHcAAAAJ&hl=en
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Christopher Wiese

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ChrisWiese@gatech.edu
Website

My research focuses on three major areas: (a) understanding and improving worker well-being, (b) temporal dynamics in team contexts, and (c) research methods. Collectively, my research seeks to improve our understanding of optimal human functioning more generally, across time, and within specific contexts (e.g., organizational, teams).

Assistant Professor
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Young Jang

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young.jang@gatech.edu
Lab Website

Dr. Jang’s lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang’s lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries.

Assistant Professor
Phone
404-385-3058
Office
Petit Biotechnology Building, Office 3304 & AP 1231
Additional Research
Dr. Jang's lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang's lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries. 1. Metabolic regulation of stem cell function 2. Systemic regulation of muscle homeostasis 3. Engineering muscle stem cell niche for regenerative medicine
Google Scholar
https://scholar.google.com/citations?user=37e-BIYAAAAJ&hl=en
https://biosci.gatech.edu/people/young-jang

Terry Snell

Terry Snell's profile picture
terry.snell@biosci.gatech.edu

Terry Snell, an Emeritus Professor in the School of Biological Sciences, is a member of the Parker H. Petit Institute for Bioengineering and Bioscience.

Professor Emeritus
Phone
404-385-4498
Office
Cherry Emerson 201
Additional Research
Chemical ecology of zooplankton; mate recognition; evolutionary ecology; aquatic toxicology; gene expression in response to environmental stress; aquaculture. 
Research Focus Areas
Google Scholar
https://scholar.google.com/citations?user=_4PzVMEAAAAJ&hl=en
http://biosciences.gatech.edu/people/terry-snell

Kirill Lobachev

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kirill.lobachev@biology.gatech.edu

My laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in the chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. 

My overall contribution to the field of genome instability has been the demonstration of the phenomenon that repeats often found in eukaryotic genomes are potent sources of genome instability. Specifically, I have been investigating one of the most fundamental and enigmatic processes as to how repetitive sequences that adopt non-canonical DNA secondary structures, such as hairpins and cruciforms, cause replication arrest, double-strand breaks, and gross chromosomal rearrangements. Using molecular biology approaches, we investigate the instability of secondary structure-forming repeats in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and human fibroblasts.

Associate Professor
Phone
404-385-6197
Office
Petit Biotechnology Building, Office 2303
Additional Research
Using yeastSaccharomyces cerevisiaeas a model, my laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying the human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. Myoverall contributionto the field of genome instability has been the demonstration of the phenomenon that repeats often found in higher eukaryotic genomes including the human genome are potent sources of double-strand breaks (DSB) and gross chromosomal rearrangements (GCR). Specifically, my lab, is investigating how repetitive sequences that can adopt non-B DNA secondary structures pose a threat to chromosomal integrity dictated by their size and arrangement. Currently three sequence motifs are studied in my laboratory: inverted repeats; Friedreich's ataxia GAA/TTC trinucleotide repeats and G-quadruplex-forming tracts. We also are collaborating with Dr. Malkova lab, University of Iowa, to study one of the outcomes of the DSB formation at unstable repeats - break-induced replication.
Research Focus Areas
Google Scholar
https://scholar.google.com/citations?user=SagVxawAAAAJ&hl=en
http://biosciences.gatech.edu/people/kirill-lobachev