Roman Mezencev

Roman Mezencev

Roman Mezencev

Adjunct Associate Professor, School of Biological Sciences

Roman Mezencev is an adjunct associate professor in the School of Biological Sciences at Georgia Tech and a scientist at the U.S. EPA’s National Center of Public Health and Environmental Assessment. His areas of research interest include cancer biology, pharmacology, toxicogenomics, protein misfolding diseases, and public health. In cancer biology, his main research focuses on using omics data to identify new cancer subtypes through molecular profiling, which can help enhance their diagnosis and treatment. Additionally, Mezencev explores the use of omics data to predict and understand chemically-induced cancer and other adverse outcomes to protect public health. He is also investigating the intriguing epidemiological associations and mechanistic connections between cancer and Alzheimer’s disease (AD), as well as other protein-misfolding diseases. By understanding these associations, we can identify shared risk factors and molecular mechanisms that can lead to the development of new anti-cancer and anti-AD drugs and enhance our understanding of these complex diseases.
 

roman.mezencev@biosci.gatech.edu

404-992-0151

https://orcid.org/0000-0003-4361-7628

Research Focus Areas:
  • Cancer Biology
  • Chemical Biology
  • Public Health
  • Systems Biology

IRI Connections:

Josiah Hester

Josiah Hester

Josiah Hester

Interim Associate Director for Community-Engaged Research
Catherine M. and James E. Allchin Early Career Professor
Professor
Director, Ka Moamoa – Ubiquitous and Mobile Computing Lab
BBISS Lead: Computational Sustainability

Josiah Hester works broadly in computer engineering, with a special focus on wearable devices, edge computing, and cyber-physical systems. His Ph.D. work focused on energy harvesting and battery-free devices that failed intermittentently. He now focuses on sustainable approaches to computing, via designing health wearables, interactive devices, and large-scale sensing for conservation. 
   
His work in health is focused on increasing accessibility and lowering the burden of getting preventive and acute healthcare. In both situations, he designs low-burden, high-fidelity wearable devices that monitor aspects of physiology and behavior, and use machine learning techniques to suggest or deliver adaptive and in-situ interventions ranging from pharmacological to behavioral. 
   
His work is supported by multiple grants from the NSF, NIH, and DARPA. He was named a Sloan Fellow in Computer Science and won his NSF CAREER in 2022. He was named one of Popular Science's Brilliant Ten, won the American Indian Science and Engineering Society Most Promising Scientist/Engineer Award, and the 3M Non-tenured Faculty Award in 2021. His work has been featured in the Wall Street Journal, Scientific American, BBC, Popular Science, Communications of the ACM, and the Guinness Book of World Records, among many others.

josiah@gatech.edu

Office Location:
TSRB 246

Personal Site

  • Ka Moamoa
  • BBISS Initiative Lead Project—Computational Sustainability
  • Research Focus Areas:
    • Climate & Environment
    • Computer Engineering
    • Cyber-Physical Systems
    • Energy Harvesting
    • Flexible Electronics
    • Lifelong Health and Well-Being
    • Medical Device Design, Development and Delivery
    • Micro and Nano Device Engineering
    • Mobile & Wireless Communications
    • Smart Cities and Inclusive Innovation
    • Social & Environmental Impacts
    • Sustainable Engineering

    IRI Connections:

    Karl Jacob

    Karl Jacob

    Karl Jacob

    Professor, School of Materials Science and Engineering and School of Mechanical Engineering

    Karl I. Jacob, a professor of Materials Science and Engineering with a joint appointment in the G. W. Woodruff School of Mechanical Engineering, teaches graduate and undergraduate courses on polymer physics and engineering, rheology, and mechanics of polymeric materials. His graduate work was in the area of numerical analysis of vibrating three-dimensional structures. He came to Georgia Tech from DuPont Corporation in 1995. His initial work at the DuPont Dacron Research Laboratory was in the area of fiber-reinforced composite materials and in the development and modeling of fiber spinning processes. He then moved to the DuPont Central Research and Development Department, where he was involved in molecular modeling, computational chemistry, and diffusion.

    Jacob is a member of the American Academy of Mechanics, the American Society of Mechanical Engineers, the Sigma Xi Research Society, and the Phi Kappa Phi Honor Society.

    karl.jacob@mse.gatech.edu

    404.894.2541

    Office Location:
    MRDC-1 4509

  • MSE Profile Page
  • University, College, and School/Department
    Research Focus Areas:
    • Biobased Materials
    • Biochemicals
    • Biorefining
    • Biotechnology
    • Computational Materials Science
    • Drug Design, Development and Delivery
    • Fuels & Chemical Processing
    • Molecular, Cellular and Tissue Biomechanics
    • Pulp Paper Packaging & Tissue
    • Sustainable Manufacturing
    Additional Research:
    "Dr. Jacob's research is directed at stress induced phase changes, nanoscale characterization of materials, synthesis of polymeric nanofibers, mechanical behavior of fiber assemblies (particularly related to biological systems and biomimitic systems), nanoparticle reinforced composites, transdermal drug delivery systems, large scale deformation of rubbery (networked) polymers, and nanoscale fracture of materials. The objectives in this work, using theoretical, computational and experimental techniques, is to understand the effect of micro- and nano- structures in the behavior of materials in order to try to design the micro/nano structures for specific materials response. Dr. Jacob plans are to continue current research interests with a multidisciplinary thrust with more emphasis in bio related areas and to start some work on the dynamic behavior of materials and structures. Graduate students could benefit from the interdisciplinary nature of the work combining classical continuum mechanics with nanoscale analysis for various applications, particularly in the nano and bio areas. Dr. Jacob has extensive experience in vibrations and stability of structures, mechanics of polymeric materials, behavior of fiber assemblies, stress-induced phase transformation, diffusion, and molecular modeling. His research involves the application of mechanics principles, both theoretical and experimental, in the analysis and design of materials for various applications.";Fibers; smart textiles; fuel cells; Polymeric composites

    IRI Connections:

    King Jordan

    King Jordan

    King Jordan

    Professor
    Director, Bioinformatics Graduate Program

    King Jordan is Professor in the School of Biological Sciences and Director of the Bioinformatics Graduate Program at the Georgia Institute of Technology. He has a computational laboratory and his group works on a wide variety of research and development projects related to: (1) human clinical & population genomics, (2) computational genomics for public health, and (3) computational approaches to functional genomics. He is particularly interested in the relationship between human genetic ancestry and health. His lab is also actively engaged in capacity building efforts in genomics and bioinformatics in Latin America. 

    king.jordan@biology.gatech.edu

    404-385-2224

    Office Location:
    EBB 2109

    Website

  • http://biosciences.gatech.edu/people/king-jordan
  • Google Scholar

    Research Focus Areas:
    • Bioinformatics
    • Computational Genomics
    • Public Health
    Additional Research:
    Epigenetics ; Computational genomics for public health. We are broadly interested in the relationship between genome sequence variation and health outcomes. We study this relationship through two main lines of investigation - human and microbial.Human:we study how genetic ancestry and population structure impact disease prevalence and drug response. Our human genomics research is focused primarily on complex common disease and aims to characterize the genetic architecture of health disparities, in pursuit of their elimination.Microbial:we develop and apply genome-enabled approaches to molecular typing and functional profiling of microbial pathogens that cause infectious disease. The goal of our microbial genomics research is to empower public health agencies to more effectively monitor and counter infectious disease agents.

    IRI Connections:

    Martha Grover

    Martha Grover

    Martha Grover

    Professor, School of Chemical and Biomolecular Engineering
    Associate Chair for Graduate Studies, School of Chemical and Biomolecular Engineering
    James Harris Faculty Fellow, School of Chemical and Biomolecular Engineering
    Member, NSF/NASA Center for Chemical Evolution

    Grover’s research activities in process systems engineering focus on understanding macromolecular organization and the emergence of biological function. Discrete atoms and molecules interact to form macromolecules and even larger mesoscale assemblies, ultimately yielding macroscopic structures and properties. A quantitative relationship between the nanoscale discrete interactions and the macroscale properties is required to design, optimize, and control such systems; yet in many applications, predictive models do not exist or are computationally intractable.

    The Grover group is dedicated to the development of tractable and practical approaches for the engineering of macroscale behavior via explicit consideration of molecular and atomic scale interactions. We focus on applications involving the kinetics of self-assembly, specifically those in which methods from non-equilibrium statistical mechanics do not provide closed form solutions. General approaches employed include stochastic modeling, model reduction, machine learning, experimental design, robust parameter design, and estimation.

    martha.grover@chbe.gatech.edu

    404.894.2878

    Office Location:
    ES&T 1228

    Grover Group

  • ChBE Profile Page
  • Google Scholar

    Research Focus Areas:
    • Electronic Materials
    • Molecular Evolution
    • Nuclear
    Additional Research:
    Colloids; Crystallization; Organic and Inorganic Photonics and Electronics; Polymers; Discrete atoms and molecules interact to form macromolecules and even larger mesoscale assemblies, ultIMaTely yielding macroscopic structures and properties. A quantitative relationship between the nanoscale discrete interactions and the macroscale properties is required to design, optimize, and control such systems; yet in many applications, predictive models do not exist or are computationally intractable. The Grover group is dedicated to the development of tractable and practical approaches for the engineering of macroscale behavior via explicit consideration of molecular and atomic scale interactions. We focus on applications involving the kinetics of self-assembly, specific those in which methods from non-equilibrium statistical mechanics do not provide closed form solutions. General approaches employed include stochastic modeling, model reduction, machine learning, experimental design, robust parameter design, estIMaTion, and optimal control, monitoring and control for nuclear waste processing and polymer organic electronics

    IRI Connections:

    Andrei Fedorov

    Andrei Fedorov

    Andrei Fedorov

    Professor and Rae S. and Frank H. Neely Chair, Woodruff School Mechanical Engineering
    Associate Chair for Graduate Studies, School Mechanical Engineering
    Director, Fedorov Lab

    Fedorov's background is in thermal/fluid sciences, chemical reaction engineering as well as in applied mathematics. His laboratory works at the intersection between mechanical and chemical engineering and solid state physics and analytical chemistry with the focus on portable/ distributed power generation with synergetic CO2 capture; thermal management of high power dissipation devices and electronics cooling; special surfaces and nanostructured interfaces for catalysis, heat and moisture management; and development of novel bioanalytical instrumentation and chemical sensors. Fedorov joined Georgia Tech in 2000 as an assistant professor after finishing his postdoctoral work at Purdue University.

    AGF@gatech.edu

    404.385.1356

    Office Location:
    Love 307

    Fedorov Lab

  • ME Profile Page
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    • Conventional Energy
    • Drug Design, Development and Delivery
    • Electronic Materials
    • Fuels & Chemical Processing
    • Hydrogen Production
    • Hydrogen Storage & Transport
    • Hydrogen Utilization
    • Materials for Energy
    • Miniaturization & Integration
    • Nuclear
    • Regenerative Medicine
    • Systems Biology
    • Use & Conservation
    Additional Research:
    Heat Transfer; power generation; CO2 Capture; Catalysis; fuel cells; "Fedorov's research is at the interface of basic sciences and engineering. His research portfolio is diverse, covering the areas of portable/ distributed power generation with synergetic carbon dioxide management, including hydrogen/CO2 separation/capture and energy storage, novel approaches to nanomanufacturing (see Figure), microdevices (MEMS) and instrumentation for biomedical research, and thermal management of high performance electronics. Fedorov's research includes experimental and theoretical components, as he seeks to develop innovative design solutions for the engineering systems whose optimal operation and enhanced functionality require fundamental understanding of thermal/fluid sciences. Applications of Fedorov's research range from fuel reformation and hydrogen generation for fuel cells to cooling of computer chips, from lab-on-a-chip microarrays for high throughput biomedical analysis to mechanosensing and biochemical imaging of biological membranes on nanoscale. The graduate and undergraduate students working with Fedorov's lab have a unique opportunity to develop skills in a number of disciplines in addition to traditional thermal/fluid sciences because of the highly interdisciplinary nature of their thesis research. Most students take courses and perform experimental and theoretical research in chemical engineering and applied physics. Acquired knowledge and skills are essential to starting and developing a successful career in academia as well as in many industries ranging from automotive, petrochemical and manufacturing to electronics to bioanalytical instrumentation and MEMS."

    IRI Connections:

    Seung Soon Jang

    Seung Soon Jang

    Seung Soon Jang

    Professor, School of Materials Science and Engineering
    Director, Computational NanoBio Technology Lab

    Seung Soon Jang joined the School of Materials Science and Engineering at the Georgia Institute of Technology in July 2007. Jang worked at Samsung Electronics and the Materials and Process Simulation Center (MSC) at CalTech performing various researches in nanoelectronics, fuel cell, and interfacial systems as a director of Supramolecular Technology for six years.

    His research interest includes computations and theories to characterize and design nanoscale systems based on the molecular architecture-property relationship, which are especially relevant to molecular electronics, molecular machines, fuel cell technology and biotechnology.

    SeungSoon@mse.gatech.edu

    404.385.3356

    Office Location:
    Love 351

    MSE Profile Page

  • Computational NanoBio Technology Lab
  • Google Scholar

    Research Focus Areas:
    • Computational Materials Science
    • Drug Design, Development and Delivery
    • Hydrogen Production
    • Hydrogen Utilization
    • Molecular, Cellular and Tissue Biomechanics
    • Nanomaterials
    Additional Research:
    Jang's research interest is to characterize and design nanoscale systems based on the molecular architecture-property relationship using computations and theories, which are especially relevant to designing new biomaterials for drug delivery and tissue engineering. Currently, he is focusing on 1) NanoBio-mechanics for DNA, lipid bilayer, and hydrogel systems; 2) Molecular interaction of Alzheimer proteins with various small molecules. Dr. Jang is also interested in various topics such as nanoelectronics, nanostructured energy technologies for fuel cell, battery and photovoltaic devices.;Computational mechanics; Nanostructured Materials; Polymeric composites; Biomaterials; Fuel Cells; Delivery and Storage

    IRI Connections:

    David Hu

    David Hu

    David Hu

    Professor, George W. Woodruff School of Mechanical Engineering
    Professor, School of Biology
    Director, Hu Lab for Biolocomotion

    David Hu is a fluid dynamicist with expertise in the mechanics of interfaces between fluids such as air and water. He is a leading researcher in the biomechanics of animal locomotion. The study of flying, swimming and running dates back hundreds of years, and has since been shown to be an enduring and rich subject, linking areas as diverse as mechanical engineering, mathematics and neuroscience. Hu's work in this area has the potential to impact robotics research. Before robots can interact with humans, aid in minimally-invasive surgery, perform interplanetary exploration or lead search-and-rescue operations, we will need a fundamental physical understanding of how related tasks are accomplished in their biological counterparts. Hu's work in these areas has generated broad interest across the fields of engineering, biology and robotics, resulting in over 30 publications, including a number in high-impact interdisciplinary journals such as Nature, Nature Materials, Proceedings of the National Academy of Sciences as well as popular journals such as Physics Today and American Scientist. Hu is on editorial board member for Nature Scientific Reports, The Journal of Experimental Biology, and NYU Abu Dhabi's Center for Center for Creative Design of Materials. He has won the NSF CAREER award, Lockheed Inspirational Young Faculty award, and best paper awards from SAIC, Sigma Xi, ASME, as well as awards for science education such as the Pineapple Science Prize and the Ig Nobel Prize. Over the years, Hu's research has also played a role in educating the public in science and engineering. He has been an invited guest on numerous television and radio shows to discuss his research, including Good Morning America, National Public Radio, The Weather Channel, and Discovery Channel. His ant research was featured on the cover of the Washington Post in 2011. His work has also been featured in The Economist, The New York Times, National Geographic, Popular Science and Discover His laboratory appeared on 3D TV as part of a nature documentary by 3DigitalVision, "Fire ants: the invincible army," available on Netflix.

    hu@me.gatech.edu

    404.894.0573

    Office Location:
    LOVE 124

    HU Laboratory for Biolocomotion

  • ME Profile Page
  • Google Scholar

    Research Focus Areas:
    • Autonomy
    • Miniaturization & Integration
    • Molecular, Cellular and Tissue Biomechanics
    Additional Research:

    Fluid Mechanics: Fluid dynamics, solid mechanics, biomechanics, animal locomotion, and physical applied mathematics. Dr. David Hu's research focuses on fundamental problems of hydrodynamics and elasticity that have bearing on problems in biology. He is interested in the dynamics of interfaces, specifically those associated with fluid-solid and solid-solid interactions. The techniques used in his work include theory, computation, and experiment. He is also interested in pursuing biomimetic technologies based on nature's designs.


    IRI Connections:

    Daniel Goldman

    Daniel Goldman

    Daniel Goldman

    Dunn Family Professor; School of Physics
    Director; Complex Rheology And Biomechanics (CRAB) Lab

    My research integrates my work in complex fluids and granular media and the biomechanics of locomotion of organisms and robots to address problems in nonequilibrium systems that involve interaction of matter with complex media. For example, how do organisms like lizards, crabs, and cockroaches cope with locomotion on complex terrestrial substrates (e.g. sand, bark, leaves, and grass). I seek to discover how biological locomotion on challenging terrain results from the nonlinear, many degree of freedom interaction of the musculoskeletal and nervous systems of organisms with materials with complex physical behavior. The study of novel biological and physical interactions with complex media can lead to the discovery of principles that govern the physics of the media. My approach is to integrate laboratory and field studies of organism biomechanics with systematic laboratory studies of physics of the substrates, as well as to create mathematical and physical (robot) models of both organism and substrate. Discovery of the principles of locomotion on such materials will enhance robot agility on such substrates

    dgoldman3@gatech.edu

    404.894.0993

    Office Location:
    Howey C202

    The Crab Lab

  • Profile on GT Physics
  • Google Scholar

    University, College, and School/Department
    Research Focus Areas:
    • Autonomy
    • Molecular, Cellular and Tissue Biomechanics
    • Neuroscience
    • Systems Biology
    Additional Research:

    biomechanics; neuromechanics; granular media; robotics; robophysics


    IRI Connections:

    M.G. Finn

    M.G. Finn

    M.G. Finn

    Chair and Professor
    James A. Carlos Family Chair for Pediatric Technology

    mgfinn@gatech.edu

    404-385-0906

    Office Location:
    MoSE 2201B

    Website

    Google Scholar

    Research Focus Areas:
    • Biomaterials
    • Drug Design, Development and Delivery
    • Molecular Evolution
    Additional Research:

    We develop chemical and biological tools for research in a wide range of fields. Some of them are briefly described below; please see our group web page for more details. Chemistry, biology, immunology, and evolution with viruses. The sizes and properties of virus particles put them at the interface between the worlds of chemistry and biology. We use techniques from both fields to tailor these particles for applications to cell targeting, diagnostics, vaccine development, catalysis, and materials self-assembly. This work involves combinations of small-molecule and polymer synthesis, bioconjugation, molecular biology, protein design, protein evolution, bioanalytical chemistry, enzymology, physiology, and immunology. It is an exciting training ground for modern molecular scientists and engineers. Development of reactions for organic synthesis, chemical biology, and materials science. Molecular function is what matters most to our scientific lives, and good chemical reactions provide the means to achieve such function. We continue our efforts to develop and optimize reactions that meet the click chemistry standard for power and generality. Our current focus is on highly reliable reversible reactions, which open up new possibilities for polymer synthesis and modification, as well as for the controlled delivery of therapeutic and diagnostic agents to biological targets. Traditional and combinatorial synthesis of biologically active compounds.We have a longstanding interest in the development of biologically active small molecules. We work closely with industrial and academic collaborators on such targets as antiviral agents, compounds to combat tobacco addiction, and treatments for inflammatory disease.


    IRI Connections: