"Intersection of Engineering and Biology across the Scales: Opportunities for Personalized Diagnostics and Printing Cellular Machines"
Rashid Bashir, Ph.D.
Dean, Grainger College of Engineering
Department of Bioengineering
Holonyak Micro and Nanotechnology Laboratory
Carle Illinois College of Medicine
University of Illinois at Urbana-Champaign
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Integration of biology, medicine, and engineering and especially fabrication methods at the micro and nano scale offers tremendous opportunities for solving important problems in biology and medicine and to enable a wide range of applications in diagnostics, therapeutics, and tissue engineering. Specifically, microfluidics and Lab-on-Chip can realize applications in detection of disease markers, counting of specific cells from whole blood, and for identification of nucleic acids using sensitive and specific, point-of-care and personalized technologies. The implication of these technologies for advancing personalized medicine for diagnosis of infection and stratification of sepsis would be discussed. Moving up the scale from nanotechnology and microfluidics, 3D bio-fabrication methods for biohybrid polymer devices can also be used to develop instrumented tissues for drug screening and biohybrid robotics.
Rashid Bashir completed his Ph.D. from Purdue University in Oct. 1992. From Oct. 1992 to Oct. 1998, he worked at National Semiconductor in the Analog/Mixed Signal Process Technology Development Group, where he was promoted to Sr. Engineering Manager. At National Semiconductor, he led the development and commercialization of 4 analog semiconductor process technologies.He joined Purdue University in Oct. 1998 as an Assistant Professor and was later promoted to Professor of Electrical and Computer Engineering and a Courtesy Professor of Biomedical Engineering and Mechanical Engineering. In Oct. 2007, he joined the University of Illinois at Urbana-Champaign as the Abel Bliss Professor of Engineering, and Professor of Electrical and Computer Engineering & Bioengineering. He was the Director of the Micro and Nanotechnology Laboratory (mntl.illinois.edu), a campus-wide clean room facility, from Oct. 2007 to Aug. 2013 and the Co-Director of the campus-wide Center for Nanoscale Science and Technology (www.cnst.illinois.edu), a "collaboratory" aimed at facilitating center grants and large initiatives around campus in the area of nanotechnology. In Oct. 2016, he was named the Grainger Distinguished Chair in Engineering. From Aug. 2013 to Aug 2017, he was the head of the Bioengineering Department. From 2017 to 2018 he was the Executive Associate Dean and the Chief Diversity Officer of the new Carle-Illinois "Engineering-Based" College of Medicine at UIUC. In Nov 2018, he was appointed as the 15th Dean of the College Engineering at the University of Illinois at Urbana-Champaign. The College was named Grainger College of Engineering in honor of W. W. Grainger in 2019.
He has authored or co-authored over 250 journal papers, over 200 conference papers and conference abstracts, and over 100 invited talks, and has been granted 45 patents. He is a fellow of 8 international professional societies (IEEE, AIMBE, AAAS, APS, IAMBE, RSC, BMES, and NAI). His research interests include bionanotechnology, BioMEMS, lab on a chip, interfacing of biology and engineering from the molecular to the tissue scale, and applications of semiconductor fabrication to biomedical engineering, all applied to solving biomedical problems. Prof. Bashir's key technical contributions and achievements lie in the area of BioMEMS and biomedical nanotechnology, especially in the use of electrical- or mechanical-based label-free methods for detection of biological entities on a chip. In addition, he has also made key contributions to 3-D fabrication methods that can be used for tissue engineering and development of cellular systems. He has been involved in 3 startups that have licensed his technologies (BioVitesse, Inc., Daktari Diagnostics, and, most recently, Prenosis, Inc.).
In addition to leading his own research group, he was the PI on an NSF IGERT on Cellular and Molecular Mechanics and Bionanotechnology (2009-2016) and PI on an NIH Training Grant on Cancer Nanotechnology (2009-2016). He is also the campus lead and Co-PI on an NSF Science and Technology Center (STC) on Emergent Behavior of Integrated Cellular Systems (headquartered at MIT, with partners at Georgia Tech and UIUC) (2009-2015, and renewed for another 5 years 2015-2020). He was also Deputy Director of the NSF Nanobio Node of the NcN (Network for Computational Nanotechnology). He also served on the external advisory board of the NIH-funded P41 BioMEMS Resource Center at Harvard/MGH and the NIH-funded Center for Cancer Nanotechnology Excellence at Stanford University, and on various editorial boards.
He holds the Grainger Distinguished Chair in Engineering, tenured appointment in bioengineering, and affiliate appointments in electrical and computer engineering, mechanical science and engineering, materials science and engineering, and molecular and integrative physiology.
The Bioengineering Seminar Series is co-hosted by the Institute for Bioengineering and Bioscience and the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, and they are open to all in the bio-community.