Paul S. Russo is a Professor of Materials Science and Engineering with a joint appointment in the School of Chemistry and Biochemistry at the Georgia Institute of Technology with expertise in polymer, biopolymer and particle chemistry.

His research interests are rooted in rodlike polymers, such as plant viruses, cellulose derivatives and aromatic backbone materials. Particular emphasis has been paid to molecular transport in complex fluids containing rods and to related measurement methods. Static and dynamic laser light scattering have been joined by fluorescence photobleaching recovery and pulsed field gradient NMR spectroscopy to measure diffusion in dilute and concentrated solutions, gels, and liquid crystals. Dialysis implementations of these techniques have permitted stability studies of the amyloid protein responsible for Alzheimer’s disease. Other materials of interest include organophilic polypeptides, which have been coupled to silica cores to yield hybrid particles that can carry hydrophobic payloads, such as enzymes. The same particles can also form colloidal crystals and linear arrays. Small-angle x-ray scattering plays a role in the characterization of these materials. Hydrophobic proteins are being used to template the synthesis of polymers in new and unusual shapes and to disperse oil following marine spills.

 In August 2023, Krishnendu Roy joined Vanderbilt University as the Bruce and Bridgitt Evans Dean of Engineering and a University Distinguished Professor in Biomedical Engineering, and Pathology, Microbiology, and Immunology, with a secondary appointment in Chemical and Biomolecular Engineering.

Previously, Roy served as Robert A. Milton Endowed Chair for the Coulter Department of Biomedical Engineering at Georgia Tech. He is also the former Director of the NSF Engineering Research Center (ERC) for Cell Manufacturing Technologies (CMaT), Center for ImmunoEngineering at Georgia Tech, and Marcus Center for Therapeutic Cell Characterization and Manufacturing. 

His overall research interests are in developing novel concepts for stem cell engineering as well as polymer controlled delivery of biological factors, especially for nucleic acid therapeutics (DNA, SiRNA and oligos) and immunoengineering. Currently, his group is involved in the following major areas of research; (a) Developing novel concepts to produce biodegradable surface functionalized micro-and nanoparticles for targeted and sustained delivery of nucleic acids, proteins, peptides and other immune modulators. In particular he is interested in developing multi-agent vaccine delivery systems for cancer and infectious diseases as well as immunotherapies for autoimmune diseases. (b) Creating spatio-temporally patterned polymer scaffolds for directed compartmental differentiation of stem cells into multiple lineages. (c) Engineering an artificial thymic niche for directed differentiation of stem cells into functional, antigen- specific T cells. (e) The development of novel nanoimprinting techniques to generate shape specific, environmentally triggered drug nanocarriers.

Faces of Research - Profile Article

H. Jerry Qi is a professor and the Woodruff Faculty Fellow in the George W. Woodruff School of Mechanical Engineering at Georgia Institute of Technology. He received his bachelor degrees (dual degree), master and Ph.D. degree from Tsinghua University (Beijing, China) and a ScD degree from Massachusetts Institute of Technology (Boston, MA, USA). After one year postdoc at MIT, he joined University of Colorado Boulder as an assistant professor in 2004, and was promoted to associate professor with tenure in 2010. He joined Georgia Tech in 2014 as an associate professor with tenure and was promoted to a full professor in 2016. Qi is a recipient of NSF CAREER award (2007). He is a member of Board of Directors for the Society of Engineering Science. In 2015, he was elected to an ASME Fellow. The research in Qi's group is in the general area of soft active materials, with a focus on 1) 3D printing of soft active materials to enable 4D printing methods; and 2) recycling of thermosetting polymers. The material systems include: shape memory polymers, light activated polymers, vitrimers. On 3D printing, they developed a wide spectrum of 3D printing capability, including: multIMaTerial inkjet 3D printing, digit light process (DLP) 3D printing, direct ink write (DIW) 3D printing, and fused deposition modeling (FDM) 3D printing. These printers allow his group to develop new 3D printing materials to meet the different challenging requirements. For thermosetting polymer recycling, his group developed methods that allow 100% recycling carbon fiber reinforced composites and electronic packaging materials. Although his group develops different novel applications, his work also relies on the understanding and modeling of material structure and properties under environmental stimuli, such as temperature, light, etc, and during material processing, such as 3D printing. Constitutive model developments are typically based on the observations from experiments and are then integrated with finite element through user material subroutines so that these models can be used to solve complicated 3D multiphysics problems involving nonlinear mechanics. A notable example is their recent pioneer work on 4D printing, where soft active materials is integrated with 3D printing to enable shape change (or time in shape forming process). Recently, his developed a state-of-the-art hybrid 3D printing station, which allows his group to integrate different polymers and conduct inks into one system. Currently, his group is working on using this printing station for a variety of applications, including printed 3D electronics, printed soft robots, etc.

Professor Mark R. Prausnitz is a Regents' Professor and the Love Family Professor in Chemical and Bimolecular Engineering in the School of Chemical & Bimolecular Engineering. He received his B.S. in 1988 from Stanford University and his Ph.D. in 1994 from the Massachusetts Institute of Technology. Professor Prausnitz and his colleagues carry out research on biophysical methods of drug delivery, which employ microneedles, ultrasound, lasers, electric fields, heat, convective forces and other physical means to control the transport of drugs, proteins, genes and vaccines into and within the body. A major area of focus involves the use of microneedle patches to apply vaccines to the skin in a painless, minimally invasive manner. In collaboration with Emory University, the Centers for Disease Control and Prevention, and other organizations, Professor Prausnitz's group is advancing microneedles from device design and fabrication through pharmaceutical formulation and pre-clinical animal studies through studies in human subjects. In addition to developing a self-administered influenza vaccine using microneedles, Professor Prausnitz is translating microneedle technology especially to make vaccination in developing countries more effective. The Prausnitz group has also developed hollow microneedles for injection into the skin and into the eye in collaboration with Emory University. In the skin, research focuses on insulin administration to human diabetic patients to increase onset of action by targeting insulin delivery to the skin. In the eye, hollow microneedles enable precise targeting of injection to the suprachoroidal space and other intraocular tissues for minimally invasive delivery to treat macular degeneration and other retinal diseases. Professor Prausnitz and colleagues also study novel mechanisms to deliver proteins, DNA and other molecules into cells. Cavitation bubble activity generated by ultrasound and by laser-excitation of carbon nanoparticles breaks open a small section of the cell membrane and thereby enables entry of molecules, which is useful for gene-based therapies and targeted drug delivery. In addition to research activities, Professor Prausnitz teaches an introductory course on engineering calculations, as well as two advanced courses on pharmaceuticals and technical communication, both of which he developed. He also serves the broader scientific and business communities as a frequent consultant, advisory board member and expert witness.

Faces of Research - Profile Article

Dr. Wilbur Lam received his B.A. from Rice University in 1995, his M.D. from the Baylor College of Medicine in 1999 and his Ph.D. from the University of California,San Francisco/University of California, Berkeley Joint Graduate Group in Bioengineering in 2008. He completed his Residency in Pediatrics from UCSF in 2002 and was a Postdoctoral Fellow at UC Berkeley from 2008-2010. Dr. Lam's research involves integrating microtechnology ,development, experimental hematology and oncology and clinical medicine. His interdisciplinary laboratory, comprising clinicians, engineers, and biologists, is dedicated to applying and developing micro/nanotechnologies to study, diagnose, and treat blood disorders, cancer, and childhood diseases. This unique "basement to bench to bedside" approach to biomedical research is enabled by our lab's dual locations at the Emory University School of Medicine and the Georgia Institute of Technology and our affiliations with the Children's Healthcare of Atlanta hospitals.

Selected recent publications:

➤ Robert G. Mannino, Eric J. Nehl, Sarah Farmer, Amanda Foster Peagler, Maren C. Parsell, Viviana Claveria, David Ku, David S. Gottfried, Hang Chen, Wilbur A. Lam, and Oliver Brand, “The critical role of engineering in the rapid development of COVID-19 diagnostics: Lessons from the RADx Tech Test Verification Core” Science Advances. 9, eade4962 (2023). https://www.science.org/doi/10.1126/sciadv.ade4962

➤ Liu ZL, Bresette C, Aidun CK, Ku DN. (2021) SIPA in 10 milliseconds: VWF tentacles agglomerate and capture platelets under high shear. Blood Advances doi.org/10.1182/bloodadvances.2021005692

➤ Kim DJ, Ku DN. “Structure of shear-induced platelet aggregated clot formed in an in vitro arterial thrombosis model” Blood Adv (2022) 6 (9): 2872–2883. doi.org/10.1182/bloodadvances.2021006248

➤ Kim DJ, Bressette C, Liu Z, Ku DN. Occlusive thrombosis in arteries.  APL Bioengineering  2019;3, 041502. https://doi.org/10.1063/1.5115554

Licensed Patents: 

➤ Ku, D.N., Wootton, D.M., Greer-Braddon, L., “Poly(vinyl Alcohol) Cryogel,” No. 5,981,826 and 6,231,605, issued May 15, 2001. Licensed; created prosthetic cartilage; acquired by Wright Medical. $645 million

➤ Denoziere, G., Ku, D.N., “Methods of Producing PVA Hydrogel Implants and Related Devices,” issued U.S. Patent No. 8,038,920, Licensed to Mimedx.  Market cap >$600 million.

Kim joined the Woodruff School of Mechanical Engineering as an Assistant Professor in July 2013. Prior to his current appointment, he was a Postdoctoral Associate in the David H. Koch Institute for Integrative Cancer Research at MIT, where he developed biomimetic microsystems for probing nanoparticle behaviors in the inflamed endothelium and for synthesizing therapeutic and diagnostic nanomaterials. His doctorate research at CMU focused on closed-loop microfluidic control systems for lab-on-a-chip applications to biochemistry and developmental biology. Prior to his Ph.D., he was a researcher in areas of dynamics, controls, and robotics at R&D Divisions of Hyundai-Kia Motors and Samsung Electronics for six years.