Our work focuses on how the brain decides which action to perform at each moment in time – that is, action selection. We are interested in the cortical and subcortical circuits that mediate this process, and how they go awry in neurological disorders such as Parkinson’s disease. Specifically, we perform measurements of large-populations of neural activity in freely behaving mice using imaging and physiology, and distill their behavior in real-time using 3D cameras and probabilistic approaches to machine learning. Additionally, we are pursuing new methods to control activity in these circuits using precision closed-loop deep brain stimulation.

Education

Masters of Science, Computer Science, Georgia Institute of Technology, 2022

Bachelors of Science, Mechanical Engineering, Georgia Institute of Technology, 2020

Research Expertise

Robot Planning and Control, Embodied Artificial Intelligence, Laboratory Automation, Software Engineering

Selected Publications

Bowles-Welch, A., Byrnes, W., Kanwar, B., Wang, B., Joffe, B., Casteleiro Costa, P., Armenta, M., Xu, J., Damen, N., Zhang, C., Mazumdar, A., Robles, F., Yeago, C., Roy, K., Balakirsky, S. (2021). Artificial Intelligence Enabled Biomanufacturing of Cell Therapies. Georgia Tech Research Institute Internal Research and Development (IRAD) Journal

Byrnes, W., Ahlin, K., Rains, G., & McMurray, G. (2019). Methodology for Stress Identification in Crop Fields Using 4D Height Data. IFAC-PapersOnLine, 52(30), 336–341. https://doi.org/10.1016/j.ifacol.2019.12.562

Byrnes, W., Kanwar, B., Damen, N., Wang, B., Bowles-Welch, A. C., Roy, K., & Balakirsky, S. (2023). Process Development and Manufacturing: A NEEDLE-BASED AUTOSAMPLER FOR BIOREACTOR CELL MEDIA COLLECTION. Cytotherapy, 25(6), S172.

Wang, B., Kanwar, B., Byrnes, W., Costa, P. C., Filan, C., Bowles-Welch, A. C., ... & Roy, K. (2023). Process Development and Manufacturing: DIGITAL TWIN-ENABLED FEEDBACK-CONTROLLED AUTOMATION WITH INTEGRATED PROCESS ANALYTICS FOR BIOMANUFACTURING OF CELL THERAPIES. Cytotherapy, 25(6), S206-S207.

Professional Activities

STEM@GTRI Program Mentor

IEEE Member

Vince Calhoun, Ph.D., is the founding director of the tri-institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) where he holds appointments at Georgia State, Georgia Tech and Emory. He is the author of more than 900 full journal articles. His work includes the development of flexible methods to analyze neuroimaging data including blind source separation, deep learning, multimodal fusion and genomics, neuroinformatics tools. Calhoun is a fellow of the Institute of Electrical and Electronic Engineers, The American Association for the Advancement of Science, The American Institute of Biomedical and Medical Engineers, The American College of Neuropsychopharmacology, The Organization for Human Brain Mapping (OHBM) and the International Society of Magnetic Resonance in Medicine. He currently serves on the IEEE BISP Technical Committee and is also a member of IEEE Data Science Initiative Steering Committee as well as the IEEE Brain Technical Committee.

Ahmet Coskun is a Bernie-Marcus Early-Career Professor of Biomedical Engineering at Georgia Institute of Technology and Emory University. Coskun is a systems biotechnologist and bioengineer, working at the nexus of multiplexed cell imaging and quantitative tissue biology. He directs an interdisciplinary research team at the Single Cell Biotechnology and Spatial Omics Laboratory, an interdisciplinary program strategically positioned for multiparameter imaging one cell at a time by spatial context and function. Coskun holds five issued patents and is also the co-author of more than 50 peer-reviewed publications in major scientific journals. He is a recipient of the NSF CAREER Award 2024, NIH R35 MIRA Award 2023, Sigma Xi Young Faculty Award 2025, CMBE Young Innovator Award 2024, BMES-CMBE Rising Star Award 2023, American Lung Association Innovation Award 2022, Burroughs Welcome Fund CASI Award 2016, and Student Recognition of Excellence in Teaching: Class of 1934 CIOS Award, among other research and teaching awards. Previously, Coskun was an instructor at Stanford University. He received his postdoctoral training from the California Institute of Technology. He holds a Ph.D. from the University of California, Los Angeles. His research has been supported by federal and private grants, including the National Institutes of Health (NIGMS, NIA, NIAID, NCI, NIDCR, OD, and ORIP), Wellcome LEAP, Burroughs Wellcome Fund (CASI), NSF CMaT, American Cancer Society IRG, Multi-cellular engineered living systems (M-CELS), and Regenerative Medicine Center. In addition, he leads outreach programs to engage K-12 students and undergraduate students through BioCrowd Studio, an innovative crowd-sourcing program bringing together interactive virtual media, distributed biokits, and collaborative spatial discovery.

Streelman grew up in Chestertown Md, where he developed a keen interest in the outdoors. He graduated with a BS in Biology from Bucknell University. While there, he attended a semester (plus one cold winter-mester) at the Marine Biological Laboratory in Woods Hole Massachusetts — where a chance encounter with Les Kaufman, Karel Liem, a few jars of pickled fish and a dental X-ray technician led to his lifelong love of cichlids. Streelman won the Pangburn Scholar-Athlete award (lacrosse) at BU. As a PhD student with Stephen Karl, Streelman developed approaches to identify, clone and sequence multiple, independent single-copy nuclear loci to reconstruct accurate phylogenies for cichlid fishes and their relatives. These phylogenies changed perspective about how these species groups evolved, and allowed new and improved inference about the evolutionary history of key ecological traits. Multi-locus phylogenies are now the standard in the field. 

As a postdoc in Tom Kocher’s lab and then a young investigator at Georgia Tech, Streelman worked on the first unbiased quantitative genetic (QTL) studies in Malawi cichlids, some of the first such studies in evolutionary systems. In particular, work showed that adaptive features of the cichlid jaw and the striking orange-blotch color polymorphism had a simple genetic basis.  

Streelman was an Alfred P. Sloan Foundation Postdoctoral Fellow, an Alfred P. Sloan Foundation Faculty Research Fellow and a NSF CAREER Awardee.  

Over the past two decades as an independent investigator, with support from the NSF, NIH and the Human Frontier Science Program, Streelman’s group has pioneered genomic and molecular biology approaches in the Malawi cichlid system to solve problems difficult to address in traditional model organisms. Major projects include (i) tooth and taste bud patterning and regeneration; (ii) the underpinnings of complex behavior; and (iii) developmental diversification of the face and brain.  

Generally, we are captivated by context-dependent traits like development and behavior because they must be executed in space and time with exquisite control. We analyze and manipulate genomes and development in multiple species of Malawi cichlids, spanning divergence in embryonic/adult traits and behavior – and collaborate with folks studying these same traits in zebrafish, mouse and human. In 2014, Streelman helped to coordinate a large effort to sequence the genomes of five East African cichlids, including one from Lake Malawi. This was a landmark for our research community and has recast attention to genome-wide approaches. We are motivated by the prospect to dissect evolutionary change with genetic and cellular precision.  

In his free time, Streelman likes mountaineering, skipping rocks and pickling.

Shu Takayama earned his BS and MS in Agricultural Chemistry at the University of Tokyo. He earned a Ph.D. in Chemistry at The Scripps Research Institute in La Jolla, California studying bio-organic synthesis with Dr. Chi‐Huey Wong. He then worked as a postdoc with Dr. George Whitesides at Harvard University where he focused on applying microfluidics to studying cell and molecular biology.

Takayama began his career at the University of Michigan, where led his lab in the Department of Biomedical Engineering and Macromolecular Science & Engineering for over 17 years. In 2017, the lab moved to Georgia Tech where Shu became the Georgia Research Alliance Price Gilbert Chair Professor of Biomedical Engineering in the Wallace H. Coulter Department of Biomedical Engineering.

Takayama’s research interests are diverse and motivated by clinical and biotechnology needs. He is always interested in hearing from stakeholders in these areas who are seeking engineering collaboration.

Young-Hui Chang is a professor in the School of Biological Sciences, Associate Dean of Faculty for College of Sciences, and director of research in the Georgia Tech Comparative Neuromechanics Lab where he studies the neuromechanics of movement in humans and other animals. Chang’s aim is to understand fundamental principles by which we control our movements as we move through our physical environment. This requires knowledge of the neural control of movement, the biomechanics of our musculoskeletal system, and the physics of our environmental interactions. The team also studies how our body adapts to acute and chronic changes. This involves processes of motor learning that are involved in everything from clinical rehabilitation to elite sports performance.

Greg Gibson is Professor of Biology and Director of the Center for Integrative Genomics at Georgia Tech. He received his BSc majoring in Genetics from the University of Sydney (Australia) and PhD in Developmental Genetics from the University of Basel. After transitioning to quantitative genetic research as a Helen Hay Whitney post-doctoral fellow at Stanford University, he initiated a program of genomic research as a David and Lucille Packard Foundation Fellow at the University of Michigan. He joined the faculty at Georgia Tech in Fall of 2009, after ten years at North Carolina State University where he developed tools for quantitative gene expression profiling and genetic dissection of development in the fruitfly Drosophila. He is now collaborating with the Center for Health Discovery and Well Being on integrative genomic analyses of the cohort. Dr Gibson is an elected Fellow of the American Association for the Advancement of Science, and serves as Section Editor for Natural Variation for PLoS Genetics. He has authored a prominent text-book, a "Primer of Genome Science" as well as a popular book about genetics and human health, "It Takes a Genome".