Georgia Tech Authors Celebration 2025

Georgia Tech faculty and staff are invited to join the Office of the Executive Vice President for Research and the Library for the annual Georgia Tech Authors Celebration.
 
This event celebrates Georgia Tech book publications, showcasing the range and depth of scholarship on our campus. The 2025 event honors authors and editors who have published books between January 2023 and December 2024.

(Re)Working AI: Designing workplace technologies with and for labor

Speaker: Sarah Fox, Assistant Professor at Carnegie Mellon University in the Human Computer Interaction Institute

Read & Publish Reception

Join us Wednesday, Oct. 16 from 4:30 to 6 p.m. in the Scholars Event Theater, located on Price Gilbert's first floor, to celebrate a transformative step towards Open Access at the Georgia Tech Library's first ever Read & Publish Reception.

Georgia Tech EVPR Chaouki Abdallah Named President of Lebanese American University

Headshot of Chaouki Abdallah wearing a navy suit jacket and gold-patterned tie with a white a shirt. Chaouki is smiling.

Chaouki Abdallah, Georgia Tech's executive vice president for Research (EVPR), has been named the new president of the Lebanese American University in Beirut.  

Abdallah, MSECE 1982, Ph.D. ECE 1988, has served as EVPR since 2018; in this role, he led extraordinary growth in Georgia Tech's research enterprise. Through the work of the Georgia Tech Research Institute, 10 interdisciplinary research institutes (IRIs), and a broad portfolio of faculty research, Georgia Tech now stands at No. 17 in the nation in research expenditures — and No. 1 among institutions without a medical school.  

Additionally, Abdallah has also overseen Tech's economic development activities through the Enterprise Innovation Institute and such groundbreaking entrepreneurship programs as CREATE-X, VentureLab, and the Advanced Technology Development Center. 

Under Abdallah's strategic, thoughtful leadership, Georgia Tech strengthened its research partnerships with historically Black colleges and universities, launched the New York Climate Exchange with a focus on accelerating climate change solutions, established an AI Hub to boost research and commercialization in artificial intelligence, advanced biomedical research (including three research awards from ARPA-H), and elevated the Institute's annual impact on Georgia's economy to a record $4.5 billion.  

Prior to Georgia Tech, Abdallah served as the 22nd president of the University of New Mexico (UNM), where he also had been provost, executive vice president of academic affairs, and chair of the electrical and computer engineering department. At UNM, he oversaw long-range academic planning, student success initiatives, and improvements in retention and graduation rates. 

A national search will be conducted for Abdallah's replacement. In the coming weeks, President Ángel Cabrera will name an interim EVPR. 

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Nanowires Create Elite Warriors to Enhance T-Cell Therapy

Ankur Singh

Ankur Singh has developed a new way of programming T cells that retains their naïve state, making them better fighters. — Photo by Jerry Grillo

 



 

Adoptive T-cell therapy has revolutionized medicine. A patient’s T-cells — a type of white blood cell that is part of the body’s immune system — are extracted and modified in a lab and then infused back into the body, to seek and destroy infection, or cancer cells. 

Now Georgia Tech bioengineer Ankur Singh and his research team have developed a method to improve this pioneering immunotherapy. 

Their solution involves using nanowires to deliver therapeutic miRNA to T-cells. This new modification process retains the cells’ naïve state, which means they’ll be even better disease fighters when they’re infused back into a patient.

“By delivering miRNA in naïve T cells, we have basically prepared an infantry, ready to deploy,” Singh said. “And when these naïve cells are stimulated and activated in the presence of disease, it’s like they’ve been converted into samurais.”

Lean and Mean

Currently in adoptive T-cell therapy, the cells become stimulated and preactivated in the lab when they are modified, losing their naïve state. Singh’s new technique overcomes this limitation. The approach is described in a new study published in the journal Nature Nanotechnology.

“Naïve T-cells are more useful for immunotherapy because they have not yet been preactivated, which means they can be more easily manipulated to adopt desired therapeutic functions,” said Singh, the Carl Ring Family Professor in the Woodruff School of Mechanical Engineering and the Wallace H. Coulter Department of Biomedical Engineering

The raw recruits of the immune system, naïve T-cells are white blood cells that haven’t been tested in battle yet. But these cellular recruits are robust, impressionable, and adaptable — ready and eager for programming.

“This process creates a well-programmed naïve T-cell ideal for enhancing immune responses against specific targets, such as tumors or pathogens,” said Singh.

The precise programming naïve T-cells receive sets the foundational stage for a more successful disease fighting future, as compared to preactivated cells.

Giving Fighter Cells a Boost

Within the body, naïve T-cells become activated when they receive a danger signal from antigens, which are part of disease-causing pathogens, but they send a signal to T-cells that activate the immune system.

Adoptive T-cell therapy is used against aggressive diseases that overwhelm the body’s defense system. Scientists give the patient’s T-cells a therapeutic boost in the lab, loading them up with additional medicine and chemically preactivating them. 

That’s when the cells lose their naïve state. When infused back into the patient, these modified T-cells are an effective infantry against disease — but they are prone to becoming exhausted. They aren’t samurai. Naïve T-cells, though, being the young, programmable recruits that they are, could be.

The question for Singh and his team was: How do we give cells that therapeutic boost without preactivating them, thereby losing that pristine, highly suggestable naïve state? Their answer: Nanowires.

NanoPrecision: The Pointed Solution

Singh wanted to enhance naïve T-cells with a dose of miRNA, a molecule that, when used as a therapeutic, works as a kind of volume knob for genes, turning their activity up or down to keep infection and cancer in check. The miRNA for this study was developed in part by the study’s co-author, Andrew Grimson of Cornell University.

“If we could find a way to forcibly enter the cells without damaging them, we could achieve our goal to deliver the miRNA into naïve T cells without preactivating them,” Singh explained.

Traditional modification in the lab involves binding immune receptors to T-cells, enabling the uptake of miRNA or any genetic material (which results in loss of the naïve state). “But nanowires do not engage receptors and thus do not activate cells, so they retain their naïve state,” Singh said.

The nanowires, silicon wafers made with specialized tools at Georgia Tech’s Institute for Electronics and Nanotechnology, form a fine needle bed. Cells are placed on the nanowires, which easily penetrate the cells and deliver their miRNA over several hours. Then the cells with miRNA are flushed out from the tops of the nanowires, activated, eventually infused back into the patient. These programmed cells can kill enemies efficiently over an extended time period.

“We believe this approach will be a real gamechanger for adoptive immunotherapies, because we now have the ability to produce T-cells with predictable fates,” says Brian Rudd, a professor of immunology at Cornell University, and co-senior author of the study with Singh.

The researchers tested their work in two separate infectious disease animal models at Cornell for this study, and Singh described the results as “a robust performance in infection control.”

In the next phase of study, the researchers will up the ante, moving from infectious disease to test their cellular super soldiers against cancer and move toward translation to the clinical setting.  New funding from the Georgia Clinical & Translational Science Alliance is supporting Singh’s research.

CITATION:  Kristel J. Yee Mon, Sungwoong Kim, Zhonghao Dai, Jessica D. West, Hongya Zhu5, Ritika Jain, Andrew Grimson, Brian D. Rudd, Ankur Singh. “Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells,” Nature Nanotechnology.

FUNDING: Curci Foundation, NSF (EEC-1648035, ECCS-2025462, ECCS-1542081), NIH (5R01AI132738-06, 1R01CA266052-01, 1R01CA238745-01A1, U01CA280984-01, R01AI110613 and U01AI131348).

Nanowires and cell

This is an image of a T cell on a nanowire array. The arrow indicates where a nanowire has penetrated the cell, delivering therapeutic miRNA.

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Jerry Grillo

ThermoFisher Scientific Summer Seminar

Please join us for a lunchtime seminar 

Wednesday, July 24, 2024 • 10:00AM - 3:00PM 
1st Floor Seminar Room Marcus Nanotechnology Bldg, 
345 Ferst Dr NW, Atlanta, GA 30332 
 

Featured topics and speakers 

Bio Summer Swap


Clean it up and Swap it out!
June 25 and June 26, 8:00 a.m. - 3:00. p.m. (both days)

Georgia Tech Joins Global Industrial Technology Cooperation Center to Advance Semiconductor Electronics Research

Electronics packaging at Georgia Tech

Georgia Tech has been selected as one of six universities globally to receive funding for the newly established Global Industrial Technology Cooperation Center. The announcement was made by the Ministry of Trade, Industry, and Energy in South Korea during the Global Open Innovation Strategy Meeting in April.

The KIAT-Georgia Tech Semiconductor Electronics Center will receive $1.8 million to establish a sustainable semiconductor electronics research partnership between Korean companies, researchers, and Georgia Tech. 

“I am thrilled to announce that we have secured funding to launch a groundbreaking collaboration between Georgia Tech’s world-class researchers and Korean companies,” said Hong Yeo, associate professor and Woodruff Faculty Fellow in the George W. Woodruff School of Mechanical Engineering and the Wallace H. Coulter Department of Biomedical Engineering. “This initiative will drive the development of cutting-edge technologies to advance semiconductor, sensors, and electronics research.”

Yeo will lead the center, and Michael Filler, interim executive director for the Institute of Electronics and Nanotechnology, and Muhannad Bakir, director of the 3D Advanced Packaging Research Center, will serve as co-PIs.

The center will focus on advancing semiconductor research, a critical area of technology that forms the backbone of modern electronics.

The Cooperation Center is a global technology collaboration platform designed to facilitate international joint research and development planning, partner matching, and local support for domestic researchers. The selection of Georgia Tech underscores the Institute’s leadership and expertise in the field of semiconductors.

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Amelia Neumeister 
Research Communications Program Manager

Biden-Harris Administration Announces Preliminary Terms with Absolics to Support Development of Glass Substrate Technology for Semiconductor Advanced Packaging

Semiconductor packaging

The Biden-Harris Administration announced that the U.S. Department of Commerce and Absolics, an affiliate of the Korea-based SKC, have signed a non-binding preliminary memorandum of terms to provide up to $75 million in direct funding under the CHIPS and Science Act to help advance U.S. technology leadership. The proposed investment would support the construction of a 120,000 square-foot facility in Covington, Georgia and the development of substrates technology for use in semiconductor advanced packaging. Started through a collaboration with the 3D Packaging Research Center at Georgia Tech, Absolics’ project serves as an example of American lab-to-fab development and production.

"Glass-core packaging holds the promise to revolutionize the field of advanced packaging and impact major paradigms such as artificial intelligence, mm-wave/THz communication, and photonic connectivity," said Muhannad Bakir, Dan Fielder Professor in the School of Electrical and Computer Engineering and Director of the 3D Systems Packaging Research Center at Georgia Tech.  "We look forward to supporting Absolics in establishing a glass-core packaging facility in the State of Georgia through workforce development initiatives." 

Because of President Biden’s CHIPS and Science Act, this proposed investment would support over an estimated 1,000 construction jobs and approximately 200 manufacturing and R&D jobs in Covington and enhance innovation capacity at Georgia Institute of Technology, supporting the local semiconductor talent pipeline. 

The proposed investment with Absolics is the first proposed CHIPS investment in a commercial facility supporting the semiconductor supply chain by manufacturing a new advanced material.

Read the full story

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Amelia Neumeister 
Research Communications Program Manager