Ryanodine receptors (RyRs) are intracellular ion channels that mediate the release of calcium from intracellular stores. RyR1 and RyR2 are the predominate isoforms in skeletal and cardiac muscle, respectively where they play a central role in excitation-contraction coupling. RyRs are the largest known ion channels and are regulated by a multitude of endogenous effectors including ions, small molecules, and accessory proteins. An area of interest is the regulation of these channels by endogenous effectors, especially as it relates to altered contractile function associated with cardiac ischemia, skeletal muscle fatigue and aging. 

Because of their central role in cellular calcium regulation, defects in RyR channels can lead to potentially fatal disorders. Mutations in RyR1 give rise to the pharmacogenetic skeletal muscle disorder, malignant hyperthermia (MH). RyR2 mutations have been identified in catecholaminergic polymorphic ventricular tachycardia. We are interested in determining the molecular mechanisms by which these mutations alter RyR channel function. 

We analyze channel function on multiples levels of organization. Sarcoplasmic reticulum vesicle [3H]ryanodine binding is used to examine large populations of channels. We incorporate channels into artificial lipid bilayers in order to record single channel currents and assess channel kinetics. Calcium release from permeabilized muscle fibers provides a method of examining RyR function in situ. My research has two long-range goals. The first is to understand how intracellular calcium is regulated and how alterations in the regulation effects cell function. The second goal is to understand the RyR regulatory sites that might be exploited for the development of pharmacological compounds to treat disorders of cellular calcium regulation.

Dr. Whiteley received his B.S. degree in Zoology in 1995 from the University of Texas at Austin and his Ph.D. in Microbiology from the University of Iowa in 2001. His doctoral research involved quorum sensing and biofilm formation in the bacterium Pseudomonas aeruginosa. Following a Postdoctoral Fellowship at Stanford University in 2002, Dr. Whiteley accepted a position as an assistant professor at the University of Oklahoma/Oklahoma Health Sciences Center. In 2006, Dr. Whiteley moved to the University of Texas at Austin where he was promoted to Professor of Molecular Biosciences and Director of the LaMontagne Center for Infectious Disease. In 2017, he accepted the Bennie H. & Nelson D. Abell Chair and Georgia Research Alliance Eminent Scholar in Molecular and Cellular Biology at Georgia Institute of Technology. He also serves as Associate Director of the CF-Air Center at Emory Medical School. Dr. Whiteley has garnered numerous awards for his work including the Merck Irving S. Sigal Memorial Award for national research excellence, the Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease award, recognition as a Kavli fellow of the National Academy of Sciences, the Dean’s teaching excellence award from UT-Austin, and election to the American Academy of Microbiology.

My lab is focused on understanding how proteins and other biological systems function at a molecular level. To probe these systems, we carry out molecular dynamics simulations, modeling biological behavior one atom at a time. The simulations serve as a "computational microscope" that permits glimpses into a cell's inner workings through the application of advanced software and high-powered supercomputers. We are particularly interested in how bacteria utilize unique pathways to synthesize proteins and insert them into both the inner and outer membranes, how they import nutrients across two membranes, and how their cell walls provide shape and mechanical strength.

• Loren Williams is from Seattle. He received his B.Sc. in Chemistry from the University of Washington, where he worked in the laboratory of Martin Gouterman. He received his Ph.D. in Physical Chemistry from Duke University, where he worked the laboratory of Barbara Shaw. He was an American Cancer Society Postdoctoral Fellow at Harvard, and an NIH Postdoctoral Fellow at MIT with Alexander Rich. He is currently a Professor in the School of Chemistry and Biochemistry at Georgia Tech. Loren is a Fellow of the AAAS and of the International Society for the Study of the Origins of Life. He was previously Director of the NASA Astrobiology Institute funded RiboEvo Center and is currently Director of the NASA-funded Center for the Origins of Life (COOL). Loren is currently a Co-Lead of the Prebiotic Chemistry and Early Earth Environment Consortium (PCE3 a NASA Research Coordination Network). Loren has received the following awards: 
• 1995 NSF Career Award 
• 1996 Sigma Xi Best Paper from Georgia Tech 
• 2012 Georgia Tech Student Advisement Award 
• 2012 Petit Institute Above and Beyond Award 
• 2013 Georgia Tech Faculty Award for Academic Outreach 
• 2013 Georgia Tech College of Science Faculty Mentor Award 
• 2017 Access Alley Award from Georgia Tech Disability Services for advocating for handicapped students 
• 2019 Vasser Woolley Award for Excellence in Instruction 
• 2020-21 Georgia Tech Outstanding Achievement in Research Program Development 
• 2021 Fellow of the International Society for Study of the Origin of Life 
• 2021 Petit Institute Above and Beyond Award 
• 2022 College of Sciences, Faculty Mentor Award 
• 2023 Fellow of the AAAS

Ravi Kane is the Garry Betty/V Foundation Chair and GRA Eminent Scholar in Cancer Nanotechnology. He received a B.S. in Chemical Engineering from Stanford University in 1993. Also, he received an M.S. in Chemical Engineering Practice and a Ph.D. in Chemical Engineering from MIT, working with Bob Cohen and Bob Silbey. After postdoctoral research with George Whitesides in the Department of Chemistry and Chemical Biology at Harvard University, he joined Rensselaer Polytechnic Institute (RPI) as an assistant professor in 2001. He was promoted to associate professor in 2006, to full professor in 2007, and to the P.K. Lashmet Professor in 2008. He served as the head of RPI’s Howard P. Isermann Department of Chemical and Biological Engineering before moving to Georgia Tech in 2015. Prof. Kane has graduated 27 Ph.D students and contributed to over 130 scientific publications.

Dr. Wood completed his graduate training at the Massachusetts Institute of Technology. While there he worked under the guidance of Drs. H. Harry Asada and Roger Kamm to develop and use microfluidics to identify mechanisms governing vascular geometry. 

During his postdoc, Dr. Wood worked under Dr. Kevin Haigis (Beth Israel Deaconess Medical Center and Harvard Medical School) and Dr. Douglas Lauffenburger (Massachusetts Institute of Technology) to use systems biology to identify novel signaling mechanisms driving neuronal death in Alzheimer's disease and epithelial cell death during intestinal inflammation.