Simon Sponberg

Simon Sponberg

Simon Sponberg

Dunn Family Associate Professor; Physics & Biological Sciences
Director; Agile Systems Lab

During his graduate work at UC, Berkeley, Simon sought to uncover general principles of animal locomotion that reveal control strategies underlying the remarkable stability and maneuverability of movement in nature. His work has demonstrated the importance animals’ natural dynamics for maintaining stability in the absence of neural feedback. His research emphasizes the importance of placing neural control in the appropriate dynamical context using mathematical and physical models. He has collaborated with researchers at four other institutions to transfer these principles to the design of the next generation of bio-inspired legged robots. 

Simon received his Ph.D. in Integrative Biology at UC, Berkeley and has been a Hertz Fellow since 2002. His work has led to fellowships and awards from the National Science Foundation, the University of California, the Woods Hole Marine Biological Institute, the American Physical Society, the Society of Integrative and Comparative Biology, and the International Association of Physics Students. He is also currently affiliated the new Center for Interdisciplinary Bio-Inspiration in Education and Research (CIBER) at Berkeley.

simon.sponberg@physics.gatech.edu

404.385.4053

Office Location:
Howey C205

Agile Systems Lab

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    University, College, and School/Department
    Research Focus Areas:
    • Neuroscience
    Additional Research:
    A central challenge for many organisms is the generation of stable, versatile locomotion through irregular, complex environments. Animals have evolved to negotiate almost every environment on this planet. To do this, animals'nervous systems acquire, process and act upon information. Yet their brains must operate through the mechanics of the body's sensors and actuators to both perceive and act upon the environment. Ourresearch investigates howphysics and physiologyenable locomoting animals to achieve the remarkable stability and maneuverability we see in biological systems. Conceptually, this demands combining neuroscience, muscle physiology, and biomechanics with an eye towards revealing mechanism and principle -- an integrative science of biological movement. This emerging field, termedneuromechanics, does for biology what mechatronics, the integration of electrical and mechanical system design, has done for engineering. Namely, it provides a mechanistic context for the electrical (neuro-) and physical (mechanical) determinants of movement in organisms. Weexplore how animals fly and run stably even in the face of repeated perturbations, how the multifuncationality of muscles arises from their physiological properties, and how the tiny brains of insects organize and execute movement.

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    Kostas Konstantinidis

    Kostas Konstantinidis

    Kostas Konstantinidis

    Professor

    Dr. Kostas Konstantinidis joined the Georgia Institute of Technology as an Assistant Professor in November 2007. He received his BS in Agriculture Sciences from the Aristotle University of Thessaloniki (Greece) in 1999. He continued his studies at the Center for Microbial Ecology at Michigan State University (East Lansing, MI) under the supervision of Prof. James M. Tiedje, where he obtained a PhD in 2004. His PhD studies were fully supported by the Bouyoukos Fellowship program and were devoted in advancing our understanding of the ecology and physiology of soil bacteria through the comparative analysis of their whole-genome sequences. This research resulted in a NSF-funded project to advance the species definition for prokaryotes, which also fostered a short post-doc position at the Center for Microbial Ecology. He then moved to MIT and the laboratory of Prof. Edward DeLong to get trained on innovating metagenomic techniques. His work at MIT provided important new insights into the complexity and function of oceanic microbial communities as well as how life is adapting in the deep and cold Oceans. His research interests are at the interface of genomics and computational biology in the context of microbial ecology with the overarching goal to broaden understanding of the genetic and metabolic potential of the microbial world. Advancing our knowledge on these issues is essential for a better understanding of the microbes that power, by and large, the biogeochemical cycles that sustain life on Earth and cause or control important diseases in humans and animals. He is a member of the American Society for Microbiology (ASM), the International Society for Microbial Ecology (ISME) and the Association of Environmental Engineering and Science Professors (AEESP). Konstantinidis held the Carlton S. Wilder Junior Professorship for five years and subsequently received the Maulding Faculty Fellowship in the School of Civil and Environmental Engineering.

    kostas.konstantinidis@gatech.edu

    404-385-3628

    Office Location:
    ES&T 3224

    Website

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    Research Focus Areas:
    • Molecular Evolution
    • Systems Biology
    Additional Research:
    Environmental microbiology and genomics Computational approaches for studying the ecology and evolution of microorganisms Development of genomic and proteomic techniques to investigate and quantify in-situ important microbial-mediated processes Population and single-cell genomics Assessing the extent and value of biodiversity within natural assemblages of Bacteria and Archaea Biotechnological applications of microbial functional diversity Environmental relevance of microbial diseases Our laboratory focuses on the smallest organisms on the planet, the bacteria and the archaea, which represent the largest reservoir of biodiversity on Earth, drive the life-sustaining biogeochemical cycles, and cause or control diseases in humans, animals, and plants. Our scientific interests are at the interface of microbial ecology with engineering and computational biology. The long-term goals of our research is to broaden understanding of the genetic and metabolic diversity of the microorganisms and to explore this biodiversity for biotechnological applications.

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    Raquel Lieberman

    Raquel Lieberman

    Raquel Lieberman

    Professor

    Raquel Lieberman is the Sepcic-Pfeil Professor of Chemistry & Biochemistry at Georgia Tech. Her research program focuses on biophysical and structural characterization of proteins and the impact of disease-associated mutations on function or dysfunction (e.g. aggregation). Rooted in basic research, the long-term goal of her research program is to convert mechanistic discoveries into disease-modifying therapies.

    A major research project in her lab is investigations of glaucoma-associated herocilin, which has been funded by NIH since March 2011. Her lab has made major strides toward detailed molecular understanding of herocilin structure, function, and disease pathogenesis. They have divulged similarities between herocilin-associated glaucoma and other protein misfolding disorders, particularly aherloid diseases. Cumulatively, their work is leading to the first disease-modifying glaucoma therapeutic.

    Lieberman also has a track record in membrane enzymes dating back to her thesis work where she solved the first crystal structure of the copper-dependent particulate methane monooxygenase. During her postdoc she shifted focus to intramembrane aspartyl proteases (IAPs), particularly those involved in neurodegenerative disease like Alzheimer’s disease. In her independent lab she developed new proteomics-based assays to measure IAP proteolysis. The lab also collaborates with physicists at Oak Ridge National Labs to use neutron scattering to probe structure and lipids in solution. This work has been funded by NSF and NIH.

    She serves on the Executive Council of the Protein Society and as an academic editor for PLoS Biology. She also serves as co-PI of the Department of Education GAANN program in Biochemistry & Biophysics at Georgia Tech and on the advisory committees in a variety of capacities.

    raquel.lieberman@chemistry.gatech.edu

    404-385-3663

    Office Location:
    Petit Biotechnology Building, Office 1308

    Website

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    Research Focus Areas:
    • Chemical Biology
    • Drug Design, Development and Delivery
    • Molecular, Cellular and Tissue Biomechanics
    Additional Research:
    The Lieberman research group focuses on biophysical and structural characterization of proteins involved in misfolding disorders. One major research project in the lab has been investigations of the glaucoma-associated myocilin protein. The lab has made major strides toward detailed molecular understanding of myocilin structure, function, and disease pathogenesis. Our research has clearly demonstrated similarities between myocilin glaucoma and other protein misfolding disorders, particularly amyloid diseases. The work has led to new efforts aimed at amelioratingthe misfolding phenotype using chemical biology approaches. Our second project involves the study of membrane-spanning proteolytic enzymes, which have been implicated disorders such as Alzheimer disease. Our group is tackling questions surrounding discrimination among and presentation of transmembrane substrates as well as the enzymatic details of peptide hydrolysis. In addition to the biochemical characterization of intramembrane aspartyl proteases, our group is developing new crystallographic tools to improve the likelihood of determining structures of similarly challenging membrane proteins more generally.

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    Marcus Cicerone

    Marcus Cicerone

    Marcus Cicerone

    Professor

    Marcus T Cicerone received his Ph.D. from the University of Wisconsin – Madison in 1994, under the direction of Mark Ediger. He spent three years at Johnson & Johnson Clinical Diagnostics, served as a visiting teaching professor at Brigham Young University for two years, and subsequently joined the National Institute of Standards and Technology in 2001, where he remained for 18 years, serving as a group leader and project leader. In January 2019 he joined the Georgia Institute of Technology as a Professor of Chemistry. 

    Professor Cicerone is a fellow of American Physical Society, and has received several awards for his efforts in coherent Raman-based biological imaging and for his work in dynamics of liquids and amorphous solids. These include a Johnson & Johnson Director’s Research Award, two Department of Commerce Bronze metals, the 2015 Washington Academy of Sciences Physical & Biological Sciences Award, and the 2017 Arthur S. Flemming Award.

    cicerone@gatech.edu

    404-894-2761

    Office Location:
    G026 MoSE

    Website

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    Research Focus Areas:
    • Cell Manufacturing
    • Chemical Biology
    • Drug Design, Development and Delivery
    Additional Research:
    Professor Cicerone works on development and application of spectroscopic coherent Raman imaging approaches and on dynamics of amorphous condensed matter. In the coherent Raman imaging work, his group introduced broadband (spectroscopic) coherent anti-Stokes Raman scattering (BCARS) microscopy in 2004. Since then he and his group have remained at the forefront of this field, introducing improvements such as a time-domain Kramers-Kronig transform to deal with non-causal signals for retrieving the pure Raman spectrum directly from the raw BCARS signal. The results of that work and other instrument design innovations utilizing impulsive vibrational coherence generation resulted in recognition as one of the top 10 innovations in BioPhotonics for 2014. His group has logged many imaging firsts, including the first to obtain quantitative vibrational fingerprint spectra from mammalian cells using coherent Raman imaging, and the first to identify specific structural proteins from coherent Raman imaging.His work on dynamics of amorphous condensed matter focuses on the impact of picosecond timescale spatial and temporal heterogeneity in dynamics on transport and relaxation in liquids and glasses. In 2004, he used neutron scattering to show for the first time that chemical and physical stability of proteins encapsulated in glassy sugars could be predicted by the profile of ps-timescale dynamics. Since then, he has developed a framework for calculating transport and relaxation properties of liquids and glasses over 12 orders of magnitude in time, based solely on ps-timescale dynamics, and identified the molecular origin of a relaxation process (Johari-Goldstein process) that had been observed but remained enigmatic for 50 years. He has also developed benchtop approaches accessible to pharmaceutical labs for measuring the relevant dynamics, and developed a protein stability approach for drug delivery that encapsulates proteins in nanometer-sized droplets of vitrified sugar-based glass and makes them impervious to traditional processing steps, allowing retention of ~99% of protein function or titer after all processing steps. This approach has now been used successfully in large animal trials, and has also been shown to be effective for transdermal drug delivery due to the nanometer size of the encapsulation materials.

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    Nian Liu

    Nian Liu

    Nian Liu

    Assistant Professor

    Nian Liu began as an Assistant Professor at Georgia Institute of Technology, School of Chemical and Biomolecular Engineering in January 2017. He received his B.S. in 2009 from Fudan University (China), and Ph.D. in 2014 from Stanford University, where he worked with Prof. Yi Cui on the structure design for Si anodes for high-energy Li-ion batteries. In 2014-2016, he worked with Prof. Steven Chu at Stanford University as a postdoc, where he developed in situ optical microscopy to probe beam-sensitive battery reactions. Dr. Liu 's lab at Georgia Tech is broadly interested in the combination of nanomaterials, electrochemistry, and light microscopy for understanding and addressing the global energy challenges. Dr. Liu is the recipient of the Electrochemical Society (ECS) Daniel Cubicciotti Award (2014) and American Chemical Society (ACS) Division of Inorganic Chemistry Young Investigator Award (2015).

    nliu82@mail.gatech.edu

    404-894-5103

    Office Location:
    ES&T 1230

    Website

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    Research Focus Areas:
    • Biomaterials
    • Hydrogen Production
    • Miniaturization & Integration
    • Nanomaterials
    • Optics & Photonics
    • Semiconductors
    Additional Research:
    Electronic Systems; Packaging and Components; Nanostructures & Materials; Optoelectronics Photonics & Phononics; Semiconductors; Materials & Processes

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    Shaheen Dewji, Ph.D.

    Shaheen Dewji, Ph.D.

    Shaheen Dewji

    Assistant Professor

    Shaheen Azim Dewji, Ph.D., (she/her/hers) is an Assistant Professor in the Nuclear & Radiological Engineering and Medical Physics Programs at the Georgia Institute of Technology, where she leads the Radiological Engineering, Detection, and Dosimetry (RED²) research group. Dewji joined Georgia Tech following three years as faculty at Texas A&M University in the Department of Nuclear Engineering, and as a Faculty Fellow of the Center for Nuclear Security Science and Policy Initiatives (NSSPI). In her prior role at Oak Ridge National Laboratory, where she remained for almost 9 years, Dewji was Radiological Scientist in the Center for Radiation Protection Knowledge. Her research interests include development of dose coefficients, shielding design, and nuclear material detection assay using gamma-ray spectroscopy. Her recent work has focused on associated challenges in uncertainty quantification in dose estimation/reconstruction associated with the external exposure and internal uptake of radionuclides associated with applications of emergency response, defense, nuclear medicine, and occupational/public safety using Monte Carlo radiation transport codes and internal dose modeling. Dewji completed her Masters and Ph.D. degrees in Nuclear and Radiological Engineering at the Georgia Institute of Technology in Atlanta, GA and was a fellow of the Sam Nunn Security Program. She received her Bachelor of Science in Physics from the University of British Columbia. Dewji currently serves on the National Academies of Science, Engineering, and Medicine – Nuclear and Radiation Studies Board and is a member of the Board of Directors for both the American Nuclear Society and Health Physics Society.
       

    shaheen.dewji@gatech.edu

    404.894.5800

    Office Location:
    Boggs 3-15

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  • Research Focus Areas:
    • AI for Security
    • Cancer Biology
    • Defense
    • Diagnostics
    • Energy
    • Health & Life Sciences
    • Machine Learning
    • Nuclear
    • Risk Management
    • Systems Biology

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    Yue Chen

    Yue Chen

    Yue Chen

    Assistant Professor; Department of Biomedical Engineering at Georgia Tech & Emory

    Yue Chen is an assistant professor in the Department of Biomedical Engineering, GT/Emory. He received his Ph.D. degree in Mechanical Engineering from Vanderbilt University, M.S. in Mechanical Engineering from Hong Kong Polytechnic University, and a B.S. in Vehicle Engineering from Hunan University. His research focused on designing, modeling, and control of continuum robots and apply them in medicine.

    yue.chen@bme.gatech.edu

    404.894.5586

    Office Location:
    UAW4105

    BioMedical Mechatronics (BM2) Lab

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    University, College, and School/Department
    Research Focus Areas:
    • Bioengineering
    • Biotechnology
    • Human Augmentation
    • Human-Centered Robotics
    • Soft Robotics

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    Ming-fai Fong

    Ming-fai Fong

    Ming-fai Fong

    Assistant Professor

    Ming-fai Fong is an Assistant Professor in the Coulter Department of Biomedical Engineering at Georgia Tech and Emory. She received her BS in Mechanical Engineering from MIT and Ph.D. in Neuroscience from Emory University. She completed her postdoctoral training in the Department of Brain and Cognitive Sciences at MIT and a visiting lectureship in the Neuroscience Department at Wellesley College.
     

    ming-fai.fong@bme.gatech.edu

    404.894.6059

    Office Location:
    UAW 3103

    https://fong-lab.github.io/

    Research Focus Areas:
    • Bioengineering
    • Health & Life Sciences
    • Neuroscience

    IRI Connections:

    Francisco Robles

    Francisco Robles

    Francisco Robles

    Associate Professor

    Dr. Francisco Robles is currently an adjunct assistant professor in the School of ECE and an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. He runs the Optical Imaging and Spectroscopy (OIS) Lab which focuses on advancing optical technologies to help improve the understanding of biological processes and the ability to identify and stage disease. The team develops and applies novel label-free linear and nonlinear spectroscopic methods, along with advanced signal processing methods, to gain access to novel forms of functional and molecular contrast for a variety of applications, including cancer detection, tumor margin assessment, and hematology. 

    Dr. Robles completed a Postdoctoral Fellowship in the Department of Chemistry at Duke University (2016), earned his Ph.D. in Medical Physics at Duke University (2011), and earned a B.S. in Physics and in Nuclear Engineering from North Carolina State University (2007).

    francisco.robles@bme.gatech.edu

    404-385-2989

    Office Location:
    UAW 3110

    Website

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    Research Focus Areas:
    • Cancer Biology
    • Chemical Biology

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