Frank Rosenzweig

Frank Rosenzweig

Frank Rosenzweig

Professor

Frank Rosenzweig is a Professor in School of Biological Sciences. He holds Bachelors degrees in Comparative Literature and Zoology from University of Tennessee-Knoxville, and a PhD in Biology at University of Pennsylvania. He carried out postdoctoral studies at the University of Michigan. He was a professor at University of Idaho, University of Florida, and University of Montana before joining the Georgia Tech faculty in 2016. He served as the Director of the NASA Astrobiology Institute funded center “Reliving the Past” from 2015 to 2019.  His research group studies the ecological and evolutionary forces that produce and preserve genetic variation using experimental evolution  to illuminate how genetic variation maps onto organismal fitness.

frank.rosenzweig@biology.gatech.edu

404-385-4458

Office Location:
EBB 2007

Website

  • http://biosci.gatech.edu/people/frank-rosenzweig
  • Research Focus Areas:
    • Molecular Evolution
    • Molecular, Cellular and Tissue Biomechanics
    • Systems Biology

    IRI Connections:

    Stephen Diggle

    Stephen Diggle

    Stephen Diggle

    Associate Professor

    I graduated in Biological Sciences (B.Sc, University of Salford, 1997) prior to undertaking a Ph.D in molecular microbiology studying quorum sensing in Pseudomonas aeruginosa (University of Nottingham, 2001). I worked as a Postdoctoral Fellow at Nottingham on both EU and BBSRC funded grants, before obtaining a Royal Society University Fellowship (2006-2014). I was promoted to Associate Professor in 2013. In 2017 I moved as an Associate Professor to the School of Biological Sciences at Georgia Tech. I was promoted to Full Professor in 2022. I was appointed as the Director of the Center for Microbial Dynamics and Infection in January 2023. 

    I currently serve as the Deputy Editor in Chief of Microbiology, where I have previously served as editor and senior editor. I have also previously served on the editorial boards of FEMS Microbiology Letters, BMC Microbiology, Microbiology Open and Royal Society Open Science. I was an elected member of the Microbiology Society Council (2012-2016) and also served on their conference and policy committees. I was selected to be an American Society for Microbiology Distinguished Lecturer (2021-2023) and was elected to the American Academy of Microbiology in 2023. 

    In my spare time I play bass guitar. I recorded some original music in a band called Meaner and I currently play in a covers band called The Variants of Concern. I also have a long-standing interest in the works of J.R.R. Tolkien.

    stephen.diggle@biosci.gatech.edu

    404-385-5634

    Office Location:
    Cherry Emerson A110

    Website

  • http://biosci.gatech.edu/people/stephen-diggle
  • Google Scholar

    Additional Research:
    I am interested in cooperation and communication in microbes and how these are related to virulence, biofilms and antimicrobial resistance. I have a long standing interest in understanding how the opportunistic pathogen Pseudomonas aeruginosa causes disease, and am especially interested in how this organism evolves during chronic infections such as those found in cystic fibrosis lungs and chronic wounds.

    IRI Connections:

    Liang Han

    Liang Han

    Liang Han

    Associate Professor

    lhan41@mail.gatech.edu

    404-385-5219

    Office Location:
    EBB 3014

    Website

    Google Scholar

    Research Focus Areas:
    • Neuroscience
    Additional Research:
    We use a combination of molecular, cellular, immunohistochemical, electrophysiological, genetic and behavioral approaches to understand how the nervous system receives, transmits and interprets various stimuli to induce physiological and behavioral responses. We are particularly interested in the basic mechanisms underlying somatosensation, including pain, itch and mechanical sensations. Somatosensation is initiated by the activation of the primary sensory neurons in dorsal root ganglia and trigeminal ganglia. We have discovered the molecular identity of itch-sensing neurons in the peripheral and provided novel insights into the mechanisms of itch sensation (Han et.al. 2013 Nature Neuroscience). We are currently investigating how chronic itch associated with cutaneous or systemic disorders is initiated and transmitted. We are also interested in the sensory innervation in the respiratory system. Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) are leading causes of illness and significant public health burdens. We recently identified a subset of vagal sensory neurons mediating bronchoconstriction and airway hyperresponsiveness (Han et. al. 2017 Nature Neuroscience). We are investigating how the sensory innervations in the airway contribute to the pathogenesis of respiratory diseases.

    IRI Connections:

    Ingeborg Schmidt-Krey

    Ingeborg Schmidt-Krey

    Ingeborg Schmidt-Krey

    Associate Professor

    Ingeborg Schmidt-Krey is an associate professor in the School of Biological Sciences at Georgia Tech. Her research interests lie in the structure and function of eukaryotic membrane proteins, two-dimensional crystallization, electron crystallography, single particle analysis, and electron cryo-microscopy (cryo-EM).

    ingeborg.schmidt-krey@biosci.gatech.edu

    404-385-0286

    Office Location:
    Cherry Emerson A118

  • http://biosciences.gatech.edu/people/ingeborg-schmidt-krey
  • Google Scholar

    Research Focus Areas:
    • Molecular, Cellular and Tissue Biomechanics
    Additional Research:
    Eukaryotic membrane proteins comprise approximately 60% of all drug targets and are consequently immensely important for biomedical research. Despite their importance, only few could thus far be studied at the structural level. My research focuses on the crystallization, structure and function of eukaryotic membrane proteins. Electron crystallography is the main tool employed to study these proteins in my laboratory. Initially, this involves testing of conditions for growing two-dimensional (2D) crystals, usually by reconstituting the detergent-solubilized membrane protein into a bilayer. Once crystallization parameters have been identified by electron microscopy of negatively stained samples, electron cryo-microscopy is employed to collect high-resolution data. The structure is then obtained by image processing. The approach of 2D crystallization and electron crystallography is particularly suitable for highly fragile membrane proteins such as many eukaryotic ones. Reconstitution ensures an environment that is close to the native one, the detergent is removed, and functional studies are relatively easily undertaken. Experimental phases are obtained due to the fact that images are collected. In some instances the image amplitudes can be substituted with electron diffraction amplitudes. Although electron crystallographic methods are well developed, little is known about the factors important in 2D crystallization, and screening protocols as for 3D crystallization do not exist. An important aspect of my research interests aims at developing screening methods and strategies for 2D crystallization and at understanding the underlying mechanisms.

    IRI Connections:

    Young Jang

    Young Jang

    Young Jang

    Assistant Professor

    Dr. Jang’s lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang’s lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries.

    young.jang@gatech.edu

    404-385-3058

    Office Location:
    Petit Biotechnology Building, Office 3304 & AP 1231

    Lab Website

  • https://biosci.gatech.edu/people/young-jang
  • Google Scholar

    Research Focus Areas:
    • Cell Manufacturing
    • Neuroscience
    • Regenerative Medicine
    Additional Research:
    Dr. Jang's lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang's lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries. 1. Metabolic regulation of stem cell function 2. Systemic regulation of muscle homeostasis 3. Engineering muscle stem cell niche for regenerative medicine

    IRI Connections:

    Terry Snell

    Terry Snell

    Terry Snell

    Professor Emeritus

    Terry Snell, an Emeritus Professor in the School of Biological Sciences, is a member of the Parker H. Petit Institute for Bioengineering and Bioscience.

    terry.snell@biosci.gatech.edu

    404-385-4498

    Office Location:
    Cherry Emerson 201

  • http://biosciences.gatech.edu/people/terry-snell
  • Google Scholar

    Research Focus Areas:
    • Molecular Evolution
    • Systems Biology
    Additional Research:
    Chemical ecology of zooplankton; mate recognition; evolutionary ecology; aquatic toxicology; gene expression in response to environmental stress; aquaculture. 

    IRI Connections:

    Kirill Lobachev

    Kirill Lobachev

    Kirill Lobachev

    Associate Professor

    My laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in the chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. 

    My overall contribution to the field of genome instability has been the demonstration of the phenomenon that repeats often found in eukaryotic genomes are potent sources of genome instability. Specifically, I have been investigating one of the most fundamental and enigmatic processes as to how repetitive sequences that adopt non-canonical DNA secondary structures, such as hairpins and cruciforms, cause replication arrest, double-strand breaks, and gross chromosomal rearrangements. Using molecular biology approaches, we investigate the instability of secondary structure-forming repeats in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and human fibroblasts.

    kirill.lobachev@biology.gatech.edu

    404-385-6197

    Office Location:
    Petit Biotechnology Building, Office 2303

  • http://biosciences.gatech.edu/people/kirill-lobachev
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    Additional Research:
    Using yeastSaccharomyces cerevisiaeas a model, my laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying the human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. Myoverall contributionto the field of genome instability has been the demonstration of the phenomenon that repeats often found in higher eukaryotic genomes including the human genome are potent sources of double-strand breaks (DSB) and gross chromosomal rearrangements (GCR). Specifically, my lab, is investigating how repetitive sequences that can adopt non-B DNA secondary structures pose a threat to chromosomal integrity dictated by their size and arrangement. Currently three sequence motifs are studied in my laboratory: inverted repeats; Friedreich's ataxia GAA/TTC trinucleotide repeats and G-quadruplex-forming tracts. We also are collaborating with Dr. Malkova lab, University of Iowa, to study one of the outcomes of the DSB formation at unstable repeats - break-induced replication.

    IRI Connections:

    Roman Mezencev

    Roman Mezencev

    Roman Mezencev

    Adjunct Associate Professor, Biological Sciences

    Roman Mezencev's research uses genomics and functional genomics data, such as transcriptomics, methylomics, miRNA-omics, proteomics, and metabolomics, to identify distinct molecular subtypes of cancer and predict their sensitivity to traditional and new targeted anticancer agents. A more precise classification of cancer and the identification of new molecular subtypes can improve therapy decision-making and provide more accurate prognostication for cancer patients. 

    In addition, he utilizes functional genomics to determine the potential of specific chemicals to cause cancer. Analyzing omics data also allows for identifying the carcinogenic mode of action of these chemicals and deriving their carcinogenic potency, which is crucial for human health risk assessment and public health considerations. 

    Furthermore, cancer also has a unique molecular and epidemiological association with neurodegenerative diseases like Alzheimer's disease (AD), which is currently the seventh leading cause of death in the U.S. Mezencev's research explores these connections to identify shared risk factors and molecular mechanisms involved in the development of cancer and AD for a better understanding of these complex diseases and cross-pollination between anticancer and anti-AD drug development.

    roman.mezencev@biosci.gatech.edu

    404-824-3700

    Google Scholar

    Additional Research:
    Cancer Biology and Carcinogenesis, Toxicogenomics, Cancer Drug Resistance, Protein Misfolding Diseases, Molecular Pathology; Epidemiology and Public Health

    IRI Connections:

    Roman Mezencev

    Roman Mezencev

    Roman Mezencev

    Adjunct Associate Professor, School of Biological Sciences

    Roman Mezencev is an adjunct associate professor in the School of Biological Sciences at Georgia Tech and a scientist at the U.S. EPA’s National Center of Public Health and Environmental Assessment. His areas of research interest include cancer biology, pharmacology, toxicogenomics, protein misfolding diseases, and public health. In cancer biology, his main research focuses on using omics data to identify new cancer subtypes through molecular profiling, which can help enhance their diagnosis and treatment. Additionally, Mezencev explores the use of omics data to predict and understand chemically-induced cancer and other adverse outcomes to protect public health. He is also investigating the intriguing epidemiological associations and mechanistic connections between cancer and Alzheimer’s disease (AD), as well as other protein-misfolding diseases. By understanding these associations, we can identify shared risk factors and molecular mechanisms that can lead to the development of new anti-cancer and anti-AD drugs and enhance our understanding of these complex diseases.
     

    roman.mezencev@biosci.gatech.edu

    404-992-0151

    https://orcid.org/0000-0003-4361-7628

    Research Focus Areas:
    • Cancer Biology
    • Chemical Biology
    • Public Health
    • Systems Biology

    IRI Connections:

    King Jordan

    King Jordan

    King Jordan

    Professor
    Director, Bioinformatics Graduate Program

    King Jordan is Professor in the School of Biological Sciences and Director of the Bioinformatics Graduate Program at the Georgia Institute of Technology. He has a computational laboratory and his group works on a wide variety of research and development projects related to: (1) human clinical & population genomics, (2) computational genomics for public health, and (3) computational approaches to functional genomics. He is particularly interested in the relationship between human genetic ancestry and health. His lab is also actively engaged in capacity building efforts in genomics and bioinformatics in Latin America. 

    king.jordan@biology.gatech.edu

    404-385-2224

    Office Location:
    EBB 2109

    Website

  • http://biosciences.gatech.edu/people/king-jordan
  • Google Scholar

    Research Focus Areas:
    • Bioinformatics
    • Computational Genomics
    • Public Health
    Additional Research:
    Epigenetics ; Computational genomics for public health. We are broadly interested in the relationship between genome sequence variation and health outcomes. We study this relationship through two main lines of investigation - human and microbial.Human:we study how genetic ancestry and population structure impact disease prevalence and drug response. Our human genomics research is focused primarily on complex common disease and aims to characterize the genetic architecture of health disparities, in pursuit of their elimination.Microbial:we develop and apply genome-enabled approaches to molecular typing and functional profiling of microbial pathogens that cause infectious disease. The goal of our microbial genomics research is to empower public health agencies to more effectively monitor and counter infectious disease agents.

    IRI Connections: