Roger Wartell

Roger Wartell

Roger Wartell received his B.S. degree in Physics from Stevens Institute of Technology in 1966. In 1971, he received his Ph.D. in Physics from the University of Rochester where he worked in the group of Elliot Montroll on the DNA helix-coil transition. From 1971-1973 he was a NIH postdoctoral fellow in the laboratory of Robert Wells at the University of Wisconsin-Madison. He was a Visiting Professor at the University of Wisconsin-Madison in 1978-79, and Visiting Scholar at National Institutes of Health-Bethesda from 1987-88. 

Wartell joined the faculty at Georgia Tech in 1974. Roger received a NIH Career Development Award in 1979 and served as Associate Chair in School of Physics from 1987-88, and Chair of the School of Biology from 1990-2004. He is a member of the NASA Astrobiology Institute at Georgia Tech. His current research is focused on protein-RNA interactions relating to sRNA regulation in bacteria, and the assembly and reactions of small RNAs in ice.

Professor Emeritus
Phone
404-894-8421
Office
Petit Biotechnology Building, Office 1307
Additional Research
Current research is directed at understanding the origin and evolution of RNA assemblies and activities that gave rise to RNA-based genetic and metabolic systems, and the interaction of a bacterial RNA-binding protein Hfq that is crucial for the regulation of gene expression by short regulatory RNAs. The first research area is examining the assembly and activities of RNAunder plausible early earth conditions ( e.g. anoxic environment, freeze-thaw cycles of aqueous solutions). We have shown that Fe2+can replace Mg2+and enhance ribozyme function under anoxic conditions. Fe2+was abundant on early earth and may have enhanced RNA activities in an anoxic environments. Freeze-thaw cycles can also promote RNA assembly under conditions where degradation is minimized. The second area of research is investigating the mechanism of the Hfq protein. Hfq is a bacterial RNA-binding protein that facilitates the hybridization of short non-coding regulatory RNAs (sRNA)to their target regions on specific mRNAs. sRNAs are important elements in the regulation of gene expression for bacteria.Hfq is highly conserved among bacterial phyla and has been shown to be a virulence factor in several bacterial species. The interactions of wild type and mutant Hfq proteins with various RNAs are examined using biochemical/ biophysical methods such as the electrophoresis mobility shift assay, fluorescence spectroscopy, and mass spectrometry.
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T. Richard Nichols

T. Richard Nichols
trn@gatech.edu

T. Richard Nichols received the B.S. degree in biology from Brown University, Providence, RI, USA, in 1969, and the Ph.D. degree in physiology from Harvard University, Cambridge, MA, USA, in 1974. He is currently a Professor in the School of Biological Sciences at the Georgia Institute of Technology.,He is currently a Professor in the School of Biological Sciences at the Georgia Institute of Technology, Atlanta, GA, USA.

Professor
Phone
404-894-3986
Office
555 14th Street NW Room 1352
Additional Research
The work in this laboratory is focused on mechanisms underlying motor coordination in mammalian systems. These mechanisms are to be found in the structure and dynamic properties of the musculoskeletal system as well as in the organization of neuronal circuits in the central nervous system. Our work concerns the interactions between the musculoskeletal system and spinal cord that give rise to normal and abnormal movement and posture, and in the manner in which central pattern-generating networks are modified for specific motor tasks. Our studies have applications in several movement disorders, including spinal cord injury. The experimental approaches span a number of levels, from mechanical studies of isolated muscle cells to kinematic measurements of natural behavior in quadrupeds.
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Frank Rosenzweig

Frank Rosenzweig
frank.rosenzweig@biology.gatech.edu
Website

Frank Rosenzweig is a Professor in School of Biological Sciences. He holds Bachelors degrees in Comparative Literature and Zoology from University of Tennessee-Knoxville, and a PhD in Biology at University of Pennsylvania. He carried out postdoctoral studies at the University of Michigan. He was a professor at University of Idaho, University of Florida, and University of Montana before joining the Georgia Tech faculty in 2016. He served as the Director of the NASA Astrobiology Institute funded center “Reliving the Past” from 2015 to 2019.  His research group studies the ecological and evolutionary forces that produce and preserve genetic variation using experimental evolution  to illuminate how genetic variation maps onto organismal fitness.

Professor
Phone
404-385-4458
Office
EBB 2007
http://biosci.gatech.edu/people/frank-rosenzweig
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Stephen Diggle

Stephen Diggle
stephen.diggle@biosci.gatech.edu
Website

I graduated in Biological Sciences (B.Sc, University of Salford, 1997) prior to undertaking a Ph.D in molecular microbiology studying quorum sensing in Pseudomonas aeruginosa (University of Nottingham, 2001). I worked as a Postdoctoral Fellow at Nottingham on both EU and BBSRC funded grants, before obtaining a Royal Society University Fellowship (2006-2014). I was promoted to Associate Professor in 2013. In 2017 I moved as an Associate Professor to the School of Biological Sciences at Georgia Tech. I was promoted to Full Professor in 2022. I was appointed as the Director of the Center for Microbial Dynamics and Infection in January 2023. 

I currently serve as the Deputy Editor in Chief of Microbiology, where I have previously served as editor and senior editor. I have also previously served on the editorial boards of FEMS Microbiology Letters, BMC Microbiology, Microbiology Open and Royal Society Open Science. I was an elected member of the Microbiology Society Council (2012-2016) and also served on their conference and policy committees. I was selected to be an American Society for Microbiology Distinguished Lecturer (2021-2023) and was elected to the American Academy of Microbiology in 2023. 

In my spare time I play bass guitar. I recorded some original music in a band called Meaner and I currently play in a covers band called The Variants of Concern. I also have a long-standing interest in the works of J.R.R. Tolkien.

Associate Professor
Phone
404-385-5634
Office
Cherry Emerson A110
Additional Research
I am interested in cooperation and communication in microbes and how these are related to virulence, biofilms and antimicrobial resistance. I have a long standing interest in understanding how the opportunistic pathogen Pseudomonas aeruginosa causes disease, and am especially interested in how this organism evolves during chronic infections such as those found in cystic fibrosis lungs and chronic wounds.
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Liang Han

Liang Han
lhan41@mail.gatech.edu
Website
Associate Professor
Phone
404-385-5219
Office
EBB 3014
Additional Research
We use a combination of molecular, cellular, immunohistochemical, electrophysiological, genetic and behavioral approaches to understand how the nervous system receives, transmits and interprets various stimuli to induce physiological and behavioral responses. We are particularly interested in the basic mechanisms underlying somatosensation, including pain, itch and mechanical sensations. Somatosensation is initiated by the activation of the primary sensory neurons in dorsal root ganglia and trigeminal ganglia. We have discovered the molecular identity of itch-sensing neurons in the peripheral and provided novel insights into the mechanisms of itch sensation (Han et.al. 2013 Nature Neuroscience). We are currently investigating how chronic itch associated with cutaneous or systemic disorders is initiated and transmitted. We are also interested in the sensory innervation in the respiratory system. Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) are leading causes of illness and significant public health burdens. We recently identified a subset of vagal sensory neurons mediating bronchoconstriction and airway hyperresponsiveness (Han et. al. 2017 Nature Neuroscience). We are investigating how the sensory innervations in the airway contribute to the pathogenesis of respiratory diseases.
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Ingeborg Schmidt-Krey

Ingeborg Schmidt-Krey
ingeborg.schmidt-krey@biosci.gatech.edu

Ingeborg Schmidt-Krey is an associate professor in the School of Biological Sciences at Georgia Tech. Her research interests lie in the structure and function of eukaryotic membrane proteins, two-dimensional crystallization, electron crystallography, single particle analysis, and electron cryo-microscopy (cryo-EM).

Associate Professor
Phone
404-385-0286
Office
Cherry Emerson A118
Additional Research
Eukaryotic membrane proteins comprise approximately 60% of all drug targets and are consequently immensely important for biomedical research. Despite their importance, only few could thus far be studied at the structural level. My research focuses on the crystallization, structure and function of eukaryotic membrane proteins. Electron crystallography is the main tool employed to study these proteins in my laboratory. Initially, this involves testing of conditions for growing two-dimensional (2D) crystals, usually by reconstituting the detergent-solubilized membrane protein into a bilayer. Once crystallization parameters have been identified by electron microscopy of negatively stained samples, electron cryo-microscopy is employed to collect high-resolution data. The structure is then obtained by image processing. The approach of 2D crystallization and electron crystallography is particularly suitable for highly fragile membrane proteins such as many eukaryotic ones. Reconstitution ensures an environment that is close to the native one, the detergent is removed, and functional studies are relatively easily undertaken. Experimental phases are obtained due to the fact that images are collected. In some instances the image amplitudes can be substituted with electron diffraction amplitudes. Although electron crystallographic methods are well developed, little is known about the factors important in 2D crystallization, and screening protocols as for 3D crystallization do not exist. An important aspect of my research interests aims at developing screening methods and strategies for 2D crystallization and at understanding the underlying mechanisms.
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Young Jang

Young Jang
young.jang@gatech.edu
Lab Website

Dr. Jang’s lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang’s lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries.

Assistant Professor
Phone
404-385-3058
Office
Petit Biotechnology Building, Office 3304 & AP 1231
Additional Research
Dr. Jang's lab uses multi-disciplinary approaches to study muscle stem cell biology and develops bioactive stem cell delivery vehicles for use in regenerative medicine. Dr. Jang's lab studies both basic aspects of muscle stem cell biology, especially systemic/metabolic regulations of stem cell and stem cell niche, as well as more translational aspects of muscle stem cell and mesenchymal stem cell for use in therapeutic approaches for musculoskeletal aging, neuromuscular diseases, and traumatic injuries. 1. Metabolic regulation of stem cell function 2. Systemic regulation of muscle homeostasis 3. Engineering muscle stem cell niche for regenerative medicine
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Terry Snell

Terry Snell
terry.snell@biosci.gatech.edu

Terry Snell, an Emeritus Professor in the School of Biological Sciences, is a member of the Parker H. Petit Institute for Bioengineering and Bioscience.

Professor Emeritus
Phone
404-385-4498
Office
Cherry Emerson 201
Additional Research
Chemical ecology of zooplankton; mate recognition; evolutionary ecology; aquatic toxicology; gene expression in response to environmental stress; aquaculture. 
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Kirill Lobachev

Kirill Lobachev
kirill.lobachev@biology.gatech.edu

My laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in the chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. 

My overall contribution to the field of genome instability has been the demonstration of the phenomenon that repeats often found in eukaryotic genomes are potent sources of genome instability. Specifically, I have been investigating one of the most fundamental and enigmatic processes as to how repetitive sequences that adopt non-canonical DNA secondary structures, such as hairpins and cruciforms, cause replication arrest, double-strand breaks, and gross chromosomal rearrangements. Using molecular biology approaches, we investigate the instability of secondary structure-forming repeats in Saccharomyces cerevisiae, Schizosaccharomyces pombe, and human fibroblasts.

Associate Professor
Phone
404-385-6197
Office
Petit Biotechnology Building, Office 2303
Additional Research
Using yeastSaccharomyces cerevisiaeas a model, my laboratory investigates molecular mechanisms underlying eukaryotic genome stability. Chromosomal rearrangements create genetic variation that can have deleterious or advantageous consequences. Karyotypic abnormalities are a hallmark of many tumors and hereditary diseases in humans. Chromosome rearrangements can also be a part of the programmed genetic modifications during cellular differentiation and development. In addition, gross DNA rearrangements play a major role in chromosome evolution of eukaryotic organisms. Therefore, elucidation of molecular mechanisms leading to chromosome instability is important for studying the human pathology and also for our understanding of the fundamental processes that determine the architecture and dynamics of eukaryotic genomes. Myoverall contributionto the field of genome instability has been the demonstration of the phenomenon that repeats often found in higher eukaryotic genomes including the human genome are potent sources of double-strand breaks (DSB) and gross chromosomal rearrangements (GCR). Specifically, my lab, is investigating how repetitive sequences that can adopt non-B DNA secondary structures pose a threat to chromosomal integrity dictated by their size and arrangement. Currently three sequence motifs are studied in my laboratory: inverted repeats; Friedreich's ataxia GAA/TTC trinucleotide repeats and G-quadruplex-forming tracts. We also are collaborating with Dr. Malkova lab, University of Iowa, to study one of the outcomes of the DSB formation at unstable repeats - break-induced replication.
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Roman Mezencev

Roman Mezencev
roman.mezencev@biosci.gatech.edu
https://orcid.org/0000-0003-4361-7628

Roman Mezencev is an adjunct associate professor in the School of Biological Sciences at Georgia Tech and a scientist at the U.S. EPA’s National Center of Public Health and Environmental Assessment. His areas of research interest include cancer biology, pharmacology, toxicogenomics, protein misfolding diseases, and public health. In cancer biology, his main research focuses on using omics data to identify new cancer subtypes through molecular profiling, which can help enhance their diagnosis and treatment. Additionally, Mezencev explores the use of omics data to predict and understand chemically-induced cancer and other adverse outcomes to protect public health. He is also investigating the intriguing epidemiological associations and mechanistic connections between cancer and Alzheimer’s disease (AD), as well as other protein-misfolding diseases. By understanding these associations, we can identify shared risk factors and molecular mechanisms that can lead to the development of new anti-cancer and anti-AD drugs and enhance our understanding of these complex diseases.
 

Adjunct Associate Professor, School of Biological Sciences
Phone
404-992-0151
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