Young-Hui Chang

Young-Hui Chang

Young-Hui Chang

Professor

Dr. Chang is the director of the Comparative Neuromechanics Laboratory. His research program focuses on trying to understand how animals move through and interact with their environment.

yh.chang@ap.gatech.edu

404-894-9993

Office Location:
1309 B

Website

  • http://biosci.gatech.edu/people/young-chang
  • Google Scholar

    Research Focus Areas:
    • Molecular, Cellular and Tissue Biomechanics
    • Neuroscience
    Additional Research:
    Current projects involve studying how gait compensations are made both from biomechanical and motor control perspectives. To this end, we study the control of human and non-human vertebrate legs within the conceptual framework of the Uncontrolled Manifold hypothesis. This idea suggests neuromechanical redundancy is not only helpful, but is exploited by the nervous system to simplify control of and completion of specific behavioral tasks, such as those involved in limb function during locomotion. We integrate concepts and tools from comparative biomechanics, neurophysiology and computational neuroscience.

    IRI Connections:

    Greg Gibson

    Greg Gibson

    Greg Gibson

    Professor
    Director, Center for Integrative Genomics
    Adjunct Professor, School of Medicine, Emory University

    Greg Gibson is Professor of Biology and Director of the Center for Integrative Genomics at Georgia Tech. He received his BSc majoring in Genetics from the University of Sydney (Australia) and PhD in Developmental Genetics from the University of Basel. After transitioning to quantitative genetic research as a Helen Hay Whitney post-doctoral fellow at Stanford University, he initiated a program of genomic research as a David and Lucille Packard Foundation Fellow at the University of Michigan. He joined the faculty at Georgia Tech in Fall of 2009, after ten years at North Carolina State University where he developed tools for quantitative gene expression profiling and genetic dissection of development in the fruitfly Drosophila. He is now collaborating with the Center for Health Discovery and Well Being on integrative genomic analyses of the cohort. Dr Gibson is an elected Fellow of the American Association for the Advancement of Science, and serves as Section Editor for Natural Variation for PLoS Genetics. He has authored a prominent text-book, a "Primer of Genome Science" as well as a popular book about genetics and human health, "It Takes a Genome".

    greg.gibson@biology.gatech.edu

    404-385-2343

    Office Location:
    EBB 2115A

    Website

  • http://www.biology.gatech.edu/people/gregory-gibson
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    • Molecular Evolution
    • Systems Biology
    Additional Research:
    Quantitative Evolutionary Genetics. After 15 years working on genomic approaches to complex traits in Drosophila, my group has spent much of the past 10 years focusing on human quantitative genetics. We start with the conviction that genotype-by-environment and genotype-by-genotype interactions are important influences at the individual level (even though they are almost impossible to detect at the population level). We use a combination of simulation studies and integrative genomics approaches to study phenomena such as cryptic genetic variation (context-dependent genetic effects) and canalization (evolved robustness) with the main focus currently on disease susceptibility.​ Immuno-Transcriptomics.As one of the early developers of statistical approaches to analysis of gene expression data, we have a long-term interest in applications of transcriptomics in ecology, evolution, and lately disease progression. Since blood is the mostaccessible human tissue, we've examined how variation is distributed within and among populations, across inflammatory and auto-immune states, and asked how it relates to variation in immune cell types. Our axes-of-variation framework provides a new way of monitoring lymphocyte, neutrophil, monocyte and reticulocyte profiles from whole peripheral blood. Most recently we have also been collaborating on numerous studies of specific tissues or purified cell types in relation to such diseases as malaria, inflammatory bowel disease, juvenile arthritis, lupus, and coronary artery disease. Predictive Health Genomics. Personalized genomic medicine can be divided into two domains: precision medicine and predictive health. We have been particularly interested in the latter, asking how environmental exposures and gene expression, metabolomic and microbial metagenomics profiles can be integrated with genomesequencing or genotyping to generate health risk assessments. A future direction is incorporation of electronic health records into genomic analyses of predictive health. Right now it is easier to predict the weather ten years in advance than loss of well-being, but we presume that preventative medicine is a big part of the future of healthcare.​

    IRI Connections:

    Yuhong Fan

    Yuhong Fan

    Yuhong Fan

    Associate Professor
    Georgia Research Alliance Distinguished Scholar

    yuhong.fan@biology.gatech.edu

    404-385-1312

    Office Location:
    Petit Biotechnology Building, Office 2313

  • Biological Sciences Profile
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    • Regenerative Medicine
    • Systems Biology
    Additional Research:
    Epigenetics, Epigenomics, Chromatin, Gene Expression, Stem Cell Biology, Epidrugs, Mouse Genetics, Cancer, Function of Linker Histones in Mammalian Development, and Stem Cell Differentiation

    IRI Connections:

    Julia Kubanek

    Julia Kubanek

    Julia Kubanek

    Professor
    Vice President of Interdisciplinary Research

    Julia Kubanek serves as Georgia Tech’s Vice President for Interdisciplinary Research and is a professor in the School of Biological Sciences and the School of Chemistry and Biochemistry. In this role, she oversees and supports interdisciplinary activities at Georgia Tech including the Interdisciplinary Research Institutes (IRIs); the Pediatric Technology Center (PTC), the Novelis Innovation Hub; the Center for Advanced Brain Imaging (CABI); and the Global Center for Medical Innovation (GCMI). She also partners across the institute on developing and advancing new research initiatives based on student and faculty interests, expertise, and societal need.

    Kubanek has held several previous leadership roles at Georgia Tech, including Associate Dean for Research in the College of Sciences and Associate Chair in the School of Biological Sciences. She joined the faculty at Georgia Tech in 2001. Her areas of research interest include chemical signaling among organisms (especially in aquatic systems), natural products chemistry, metabolomics, chemical biology, and drug discovery. She has authored approximately 100 research articles on marine plankton and coral reef chemical ecology, and on the discovery, mechanism of action, and biosynthesis of marine natural products. She was awarded the NSF CAREER Award in 2002, the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2004, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012. In 2016, she served as chair of the Gordon Research Conference in Marine Natural Products; since 2016, she has chaired the Scientific Advisory Board of the Max Planck Institute for Chemical Ecology. Kubanek received her B.Sc. in Chemistry from Queen’s University, Canada, in 1991 and her Ph.D. in at the University of British Columbia in 1998, and performed postdoctoral research at the University of California – San Diego and the University of North Carolina at Wilmington.

    julia.kubanek@biosci.gatech.edu

    404-894-8424

    Office Location:
    ES&T 2242

    Website

  • http://biosciences.gatech.edu/people/julia-kubanek
  • Google Scholar

    Research Focus Areas:
    • Drug Design, Development and Delivery
    • Health & Life Sciences
    • Systems Biology
    Additional Research:
    All organisms use chemicals to assess their environment and to communicate with others. Chemical cues for defense, mating, habitat selection, and food tracking are crucial, widespread, and structurally and functionally diverse. Yet our knowledge of chemical signaling is patchy, especially in marine environments. In our research we ask, "How do marine organisms use chemicals to solve critical problems of competition, disease, predation, and reproduction?" Our group uses an integrated approach to understand how chemical cues function in ecological interactions, working from molecular to community levels. We also use ecological insights to guide discovery of novel pharmaceuticals and molecular probes. In collaboration with other scientists, our most significant scientific achievements to date are: 1) characterizing the unusual molecular structures of antimicrobial defenses that protect algae from pathogens and which show promise to treat human disease; 2) understanding that competition among single-celled algae (phytoplankton) is mediated by a complex interplay of chemical cues that affect harmful algal bloom dynamics; 3) unraveling the molecular modes of action of antimalarial natural products towards developing new treatments for drug-resistant infectious disease; 4) discovering that progesterone signaling and quorum sensing are key pathways in the alternating sexual and asexual reproductive strategy of microscopic invertebrate rotifers - animals whose evolutionary history was previously thought to preclude either cooperative behavior (quorum sensing) typically associated with bacteria and hormonal regulation via progesterone typically seen in vertebrates; 5) identifying a novel aversivechemoreception pathway in predatory fish thatresults inrapid recognition and rejectionofchemically defended foods, thereby protecting these foods (prey) from predators. Ongoing projects include: 1) Waterborne chemical cues in the marine plankton: a systems biology approach (including metabolomics); 2) Exploration, conservation, and development of marine biodiversity in Fiji and the Solomon Islands (including drug discovery, mechanisms of action, and chemical ecology); 3) The role of sensory environment and predator chemical signal properties in determining non-consumptive effect strength in cascading interactions on oyster reefs; 4) Regulation of red tide toxicity by chemical cues from marine zooplankton; 5) Chemoreception of prey chemical defenses on tropical coral reefs.

    IRI Connections:

    Shuyi Nie

    Shuyi Nie

    Shuyi Nie

    Assistant Professor

    Dr. Nie received her B.S. degree in Biology from Peking University in China in 2002. In 2007, she received her Ph.D. in Cell Biology from the University of Alabama at Birmingham, where she worked on elucidating signaling pathways in vertebrate gastrulation movements. Thereafter, she conducted postdoctoral research in the laboratory of Marianne Bronner at California Institute of Technology. She joined Georgia Tech in Fall 2014.

    shuyi.nie@biology.gatech.edu

    404-385-3694

    Office Location:
    EBB 3009

    Website

  • http://biosciences.gatech.edu/people/shuyi-nie
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    • Molecular, Cellular and Tissue Biomechanics
    Additional Research:
    The fundamental question we are trying to answer is how the coordinated cell movements are regulated during animal development. Different groups of cells move to different locations in a growing embryo to give rise to specific tissue and structures. It is a very complex process since the "ground" cells travel on is also undergoing constant rearrangement and growth. We use neural crest as a model to study the mechanisms of cell migration during embryonic development. The neural crest is a vertebrate innovation, comprised of highly migratory stem-like cells that give rise to multiple tissue and structures, including craniofacial bones and cartilages, connective tissue in the heart, enteric nervous system in the gut, and pigment cells all over the skin. Defects in their proliferation, migration, differentiation, or survival lead to numerous diseases and birth defects, including craniofacial and heart malformations as well as different types of cancer. Ongoing studies aim to uncover how their migration is regulated and how do they achieve such extraordinary migratory abilities.

    IRI Connections:

    Francesca Storici

    Francesca Storici

    Francesca Storici

    Professor

    Francesca Storici was born in Trieste, Italy. She graduated in Biology from the University of Trieste. Her Ph.D. in Molecular Genetics was conferred by the International School for Advanced Studies (SISSA), in Trieste in 1998, and she conducted research at the International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste. From 1999 to 2007 she was an NIH postdoctoral fellow in the Laboratory of Molecular Genetics under the guidance of Dr. Michael A. Resnick at the National Institute of Environmental and Health Sciences (NIEHS, NIH) in the Research Triangle Park of North Carolina, USA. In 2007 she was a Research Assistant Professor at the Gene Therapy Center of the University on North Carolina at Chapel Hill with Dr. R. Jude Samulski. Francesca joined the faculty of the School of Biological Sciences at Georgia Tech in 2007 and received the title of Distinguished Cancer Scientist of the Georgia Research Alliance. She is currently a professor in the School of Biological Sciences at Georgia Tech. Her research is on genome stability, DNA repair and gene targeting.

    francesca.storici@biology.gatech.edu

    404-385-3339

    Office Location:
    EBB 5017

    Website

  • http://biosciences.gatech.edu/people/francesca-storici
  • Google Scholar

    Research Focus Areas:
    • Cancer Biology
    • Drug Design, Development and Delivery
    Additional Research:
    Ribonucleotides embedded in DNA, RNA-driven DNA repair and modifications, mechanisms of genomic stability/instability, gene targeting and genome engineering.

    IRI Connections:

    Frank Stewart

    Frank Stewart

    Frank Stewart

    Adjunct Associate Professor

    I am an environmental microbiologist interested in the dynamics of microbial systems.  My research is motivated by the beliefs that microbes are a frontier for natural history and scientific discovery, and that exploring this frontier is necessary and important for understanding biological diversity and its changing role in ecosystem processes. The first major research theme in my lab explores how aquatic microbes respond to environmental change, notably declines in ocean oxygen content.  The second major theme explores how life in symbiosis drives microbial evolution and ecology.  My research targets diverse systems, from the marine water column to the intestinal microbiomes of fishes.  This research aims to identify metabolic properties that underlie the ecology of microbes and microbe-host systems, the evolutionary context under which these functions arose, and the role of these functions in ecosystem-scale processes in a changing environment.  

    I am an Associate Professor in the Department of Microbiology and Immunology at Montana State University and an Adjunct Professor in the School of Biological Sciences at Georgia Tech.  I received a B.A. in Biology from Middlebury College and a Ph.D. in Organismic and Evolutionary Biology from Harvard University.  I worked as a Postdoctoral Fellow at MIT for two years before moving to Georgia Tech in January 2011.  In February 2020, I moved my lab to the mountains of Montana.  My work has been recognized through an NSF CAREER award, a Sloan Research Fellowship, and a Simons Foundation Early Career investigator award.  

    frank.stewart@biology.gatech.edu

    404-894-5819

    Office Location:
    ES&T 1242

    Website

  • http://biosciences.gatech.edu/people/frank-stewart
  • Google Scholar

    Research Focus Areas:
    • Molecular Evolution
    Additional Research:
    Bacteria and Archaea constitute the overwhelming majority of genetic and metabolic diversity on this planet. To understand these organisms in their native habitats, environmental microbiologists are tasked with two fundamental questions. First, how do ecological and evolutionary processes (e.g., symbiosis, competition, recombination, natural selection) create and structure genetic diversity? Second, how is this genetic diversity linked to the diverse biogeochemical functions of microorganisms in nature? Our research explores these questions for marine microorganisms, using the tools of genomics and molecular biology. We are particularly interested in how microbial genome evolution and physiology are affected by symbiotic interactions with higher taxa. In tandem with this work, we study free-living microorganisms, as they provide important reference points for understanding symbiont biology and mediate key global biogeochemical cycles in the ocean's water column and sediments. In particular, we are interested in how oxygen loss affects the diversity and metabolism of marine microbes. Our research integrates the broad fields of microbiology, molecular evolution, and marine biology. This work has both descriptive and experimental components, and involves a blend of field, molecular, and bioinformatic techniques, the latter focused in part on the analysis of high-throughput sequencing datasets. We welcome inquiries from potential students, post-docs, and collaborators who share these interests.

    IRI Connections:

    Edward Balog

    Edward Balog

    Edward Balog

    Associate Professor

    Ryanodine receptors (RyRs) are intracellular ion channels that mediate the release of calcium from intracellular stores. RyR1 and RyR2 are the predominate isoforms in skeletal and cardiac muscle, respectively where they play a central role in excitation-contraction coupling. RyRs are the largest known ion channels and are regulated by a multitude of endogenous effectors including ions, small molecules, and accessory proteins. An area of interest is the regulation of these channels by endogenous effectors, especially as it relates to altered contractile function associated with cardiac ischemia, skeletal muscle fatigue and aging. 

    Because of their central role in cellular calcium regulation, defects in RyR channels can lead to potentially fatal disorders. Mutations in RyR1 give rise to the pharmacogenetic skeletal muscle disorder, malignant hyperthermia (MH). RyR2 mutations have been identified in catecholaminergic polymorphic ventricular tachycardia. We are interested in determining the molecular mechanisms by which these mutations alter RyR channel function. 

    We analyze channel function on multiples levels of organization. Sarcoplasmic reticulum vesicle [3H]ryanodine binding is used to examine large populations of channels. We incorporate channels into artificial lipid bilayers in order to record single channel currents and assess channel kinetics. Calcium release from permeabilized muscle fibers provides a method of examining RyR function in situ. My research has two long-range goals. The first is to understand how intracellular calcium is regulated and how alterations in the regulation effects cell function. The second goal is to understand the RyR regulatory sites that might be exploited for the development of pharmacological compounds to treat disorders of cellular calcium regulation.

    ed.balog@ap.gatech.edu

    404-894-3957

    Office Location:
    AP 1303

    Website

  • http://biosci.gatech.edu/people/edward-balog
  • Google Scholar

    Research Focus Areas:
    • Regenerative Medicine
    Additional Research:
    Research in our laboratory focuses on a class of intracellular ion channels know as ryanodine receptors (RyRs). In mammals, there are three RyR isoforms. RyR1 and RyR2 are the predominate isoforms in skeletal and cardiac muscle, respectively where they are the primary efflux pathway for the release of calcium from the sarcoplasmic reticulum to activate contraction. RyR3 has a wide tissue distribution and contributes to calcium regulation in a variety of cell types. RyRs are the largest known ion channel and are regulated by a multitude of endogenous effectors, including ions, metabolites and regulatory proteins. Therefore, an area of interest is the regulation of these RyR channels by endogenous effectors; especially as it relates to altered contractile function associated with cardiac and skeletal disease, skeletal muscle fatigue and aging. We analyze channel function on multiples levels of organization. Sarcoplasmic reticulum vesicle [3H]ryanodine binding is used to examine large populations of channels. Individual channels are incorporated into artificial lipid bilayers in order to record single channel currents and assess channel kinetics. Calcium release from permeabilized muscle fibers provides a method of examining RyR function in situ. My research has two long-range goals. The first is to understand how intracellular calcium is regulated and how alterations in the regulation effects cell function. The second goal is to understand the RyR regulatory sites that could potentially be exploited for the development of pharmacological compounds to treat disorders of cellular calcium regulation.

    IRI Connections:

    Alberto Stolfi

    Alberto Stolfi

    Alberto Stolfi

    Assistant Professor

    We study the simple larval nervous system of our closest invertebrate relatives, the tunicates. Tunicates, like us, belong to the Chordate phylum, but have very simple embryos and compact genomes. The laboratory model tunicate Ciona has only 177 neurons and is the only chordate with a fully mapped "connectome". We take advantage of this simplicity to understand molecular mechanisms that may underlie human neurodevelopment. We use transcriptome profiling to assay global transcriptional dynamics in neural progenitors during Ciona development, and use CRISPR/Cas9 to knock out important transcription factors and their downstream targets to understand how these gene networks control neuronal specification, morphology, physiology, neurotransmitter identity, and connectivity.

    alberto.stolfi@biosci.gatech.edu

    404-385-5975

    Office Location:
    EBB 4014

    Website

  • College of Sciences Profile
  • Google Scholar

    Research Focus Areas:
    • Neuroscience
    Additional Research:
    We seek to answer how animal behavior is set up by the collective behaviors of individual cells, over the entire course of brain and spinal cord development. We want to understand how gene activity can instruct developing neurons to move around, change shape, and connect to other cells. To do this, we study the simple larval nervous system of our closest invertebrate relatives, the tunicates. Tunicates, like us, belong to the Chordate phylum, but have very simple embryos and compact genomes. The laboratory model tunicate Ciona has only 177 neurons and is the only chordate with a fully mapped "connectome". We take advantage of this simplicity to understand molecular mechanisms that may underlie human neurodevelopment.

    IRI Connections:

    Marvin Whiteley

    Marvin Whiteley

    Marvin Whiteley

    Professor
    Bennie H. & Nelson D. Abell Chair in Molecular and Cellular Biology
    Georgia Research Alliance Eminent Scholar
    Co-Director, Emory-Children's CF Center (CF@LANTA)

    Dr. Whiteley received his B.S. degree in Zoology in 1995 from the University of Texas at Austin and his Ph.D. in Microbiology from the University of Iowa in 2001. His doctoral research involved quorum sensing and biofilm formation in the bacterium Pseudomonas aeruginosa. Following a Postdoctoral Fellowship at Stanford University in 2002, Dr. Whiteley accepted a position as an assistant professor at the University of Oklahoma/Oklahoma Health Sciences Center. In 2006, Dr. Whiteley moved to the University of Texas at Austin where he was promoted to Professor of Molecular Biosciences and Director of the LaMontagne Center for Infectious Disease. In 2017, he accepted the Bennie H. & Nelson D. Abell Chair and Georgia Research Alliance Eminent Scholar in Molecular and Cellular Biology at Georgia Institute of Technology. He also serves as Associate Director of the CF-Air Center at Emory Medical School. Dr. Whiteley has garnered numerous awards for his work including the Merck Irving S. Sigal Memorial Award for national research excellence, the Burroughs Wellcome Investigators in Pathogenesis of Infectious Disease award, recognition as a Kavli fellow of the National Academy of Sciences, the Dean’s teaching excellence award from UT-Austin, and election to the American Academy of Microbiology.

    marvin.whiteley@biosci.gatech.edu

    404-385-5697

    Office Location:
    Petit Biotechnology Building, Office 1314

    Website

  • http://biosci.gatech.edu/people/marvin-whiteley
  • Google Scholar

    Research Focus Areas:
    • Drug Design, Development and Delivery
    • Systems Biology
    Additional Research:
    In the Whiteley Lab, we are interested in the social lives of bacteria. Currently, we are utilizing new technologies combined with classical genetic techniques to address questions about microbial physiology, ecology, virulence, and evolution. In particular, we are working on tackling the following questions: 1. How do bacteria communicate? 2. How do polymicrobial interactions impact physiology and virulence? 3. What is the role of spatial structure in bacterial infections? 4. How does the host environment impact microbial physiology?

    IRI Connections: