Georgia Tech Opens New Aircraft Prototyping Laboratory

Joby Aviation Aircraft

Joby is one of more than a dozen companies worldwide that are developing the next generation of aircraft that could be wishing you around the city bypassing any traffic. (Courtesy of Joby)

Georgia Tech celebrates the opening of its new Aircraft Prototyping Laboratory, a facility dedicated to advancing research in electric and autonomous flight in collaboration with academic, government, and industry partners. The ribbon-cutting ceremony will take place on Sept. 25, marking an important step forward for the Daniel Guggenheim School of Aerospace Engineering and highlighting Georgia Tech’s role in strengthening the state’s aerospace sector through technical research, engineering expertise, and student training. 

“This facility demonstrates Georgia Tech’s long-term commitment to pioneering the technologies that will shape the future of aviation,” said Ángel Cabrera, president of Georgia Tech. “Aerospace products are Georgia’s No. 1 export, and the Institute’s top-ranked Guggenheim School produces some of the nation’s top aerospace engineering talent. With this advanced laboratory, we’re making strategic investments that will grow our state’s and our Institute’s national leadership in aerospace innovation and advanced manufacturing.” 

The 10,000-square-foot facility, located in Georgia Tech’s North Avenue Research Area, has been purpose-built to accelerate innovation in electric and hybrid-electric aircraft propulsion as well as autonomous flight systems. Designed as a hands-on research and teaching environment, the Aircraft Prototyping Laboratory includes a suite of specialized laboratories: an electric powertrain lab, a propulsion system test cell, an avionics lab, a composites fabrication area, and a high-bay integration space capable of housing prototype aircraft with wingspans up to 20 feet.  

One of the facility’s first major projects is RAVEN (Research Aircraft for eVTOL Enabling techNologies), a collaboration with NASA to design, build, and fly an electric vertical takeoff and landing (eVTOL) research aircraft in the 1,000-pound weight class. The aircraft will serve as a research platform for electric propulsion reliability, flight controls, noise reduction, and autonomy. Systems integration and test activities for RAVEN will take place within the new lab, underscoring the facility’s central role in shaping the national agenda for advanced air mobility. 

“The Aircraft Prototyping Laboratory is the centerpiece of an ecosystem of flight research that we are building at Georgia Tech, focused on eVTOLs, drones, and other advanced air vehicles,” said Brian German, professor of aerospace engineering at Georgia Tech. “We greatly appreciate the long-term partnership we’ve had with NASA in the development of RAVEN, and we’ve designed the facility specifically to support RAVEN and aircraft of a similar scale.”  

Other projects underway in the Aircraft Prototyping Laboratory include a solar-electric aircraft demonstrator and SETTER, a subscale eVTOL testbed focused on developing software for safety-critical applications. These projects support Georgia Tech’s expanding ecosystem for flight testing and research, including collaborations with regional test facilities in the metro Atlanta area. 

“These projects exemplify our commitment to advancing the technologies that will define the future of flight. Powered by the ingenuity of our faculty and students, the Aircraft Prototyping Laboratory ensures that Georgia Tech and the state of Georgia remain leaders in aerospace innovation and economic development,” said Mitchell Walker, William R.T. Oakes Professor and chair of the Daniel Guggenheim School of Aerospace Engineering.

Through the Aircraft Prototyping Laboratory, Georgia Tech continues to develop research in electric and autonomous aircraft, supporting both the Institute’s and Georgia’s role in the aerospace industry. The school educates more than 2,000 aerospace students and is ranked No. 1 among public universities for aerospace engineering. 

 
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Angela Barajas Prendiville 
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A Step Forward: New Smart Shoe Insert Could Improve Mobility for People With Walking Problems

Hong Yeo holds shoe insert.

Hong Yeo holds the wearable electronic device made of more than 170 thin, flexible sensors that measure foot pressure — a key metric for determining whether someone is off-balance. [Photos by Joya Chapman]

Maintaining balance while walking may seem automatic — until suddenly it isn’t. Gait impairment, or difficulty with walking, is a major liability for stroke and Parkinson’s patients.  Not only do gait issues slow a person down, but they are also one of the top causes of falls. And solutions are often limited to time-intensive and costly physical therapy.

A new wearable electronic device that can be inserted inside any shoe may be able to address this challenge. The device, developed by Georgia Tech researchers, is made of more than 170 thin, flexible sensors that measure foot pressure — a key metric for determining whether someone is off-balance. The sensor collects pressure data, which the researchers could eventually use to predict which changes lead to falls.

The researchers presented their work in the paper, “Flexible Smart Insole and Plantar Pressure Monitoring Using Screen-Printed Nanomaterials and Piezoresistive Sensors.” It was the cover paper in the August edition of ACSApplied Materials & Interfaces

Pressure Points

Smart footwear isn’t new — but making it both functional and affordable has been nearly impossible. W. Hong Yeo’s lab has made its reputation on creating malleable medical devices. The researchers rely on the common commercial practice of screen-printing electronics to screen-print sensors. They realized they could apply this printing technique to address walking difficulties.

“Screen-printing is advantageous for developing medical devices because it's low-cost and scalable,” said Yeo, the Peterson Professor and Harris Saunders Jr. Professor in the George W. Woodruff School of Mechanical Engineering. “So, when it comes to thinking about commercialization and mass production, screen-printing is a really good platform because it's already been used in the electronics industry.”

Making the device accessible to the everyday user was paramount for Yeo’s team. A key innovation was making sure the wearable is thin enough to be comfortable for the wearer and easy to integrate with other assistive technologies. The device uses Bluetooth, enabling a smartphone to collect data and offer the future possibility of integrating with existing health monitoring applications.

Possibilities for real-world adaptation are promising, thanks to these innovations. Lightweight and small, the wearable could be paired with robotics devices to help stroke and Parkinson’s patients and the elderly walk. The high number of sensors could make it easier for researchers to apply a machine learning algorithm that could predict falls. The device could even enable professional athletes to analyze their performance.

Regardless of how the device is used, Yeo intends to keep its cost under $100. So far, with funding from the National Science Foundation, the researchers have tested the device on healthy subjects. They hope to expand the study to people with gait impairments and, eventually, make the device commercially available. 

“I'm trying to bridge the gap between the lack of available devices in hospitals or medical practices and the lab-scale devices,” Yeo said. “We want these devices to be ready now — not in 10 years.”

With its low-cost, wireless design and potential for real-time feedback, this smart insole could transform how we monitor and manage walking difficulties — not just in clinical settings, but in everyday life. 

Shoe insert
 
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Tess Malone, Senior Research Writer/Editor

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The Robotic Breakthrough That Could Help Stroke Survivors Reclaim Their Stride

research lab showing a test subject using an exoskeleton to help with gait

Georgia Tech's AI-fueled exoskeleton adapts to every step, helping patients relearn to walk with less effort and more confidence.

Crossing a room shouldn’t feel like a marathon. But for many stroke survivors, even the smallest number of steps carries enormous weight. Each movement becomes a reminder of lost coordination, muscle weakness, and physical vulnerability.

A team of Georgia Tech researchers wanted to ease that struggle, and robotic exoskeletons offered a promising path. Their findings point to a simple but powerful shift: exoskeletons that adapt to people, rather than forcing people to adapt to the machine. Using artificial intelligence (AI) to learn the rhythm of patients’ strides in real time, the team showed how these devices can reduce strain and increase efficiency. They also demonstrated how the technology can help restore confidence for stroke survivors. 

The Robot Finds the Rhythm

A robotic exoskeleton is a wearable device that helps people move with mechanical support. Traditional exoskeletons require endless manual adjustments — turning knobs, calibrating settings, and tweaking controls. 

“It can be frustrating, even nearly impossible, to get it right for each person,” said Aaron Young, associate professor in the George W. Woodruff School of Mechanical Engineering. “With AI, the exoskeleton figures out the mapping itself. It learns the timing of someone’s gait through a neural network, without an engineer needing to hand-tune everything.”

The software monitors each step, instantly updates, and fine-tunes the support it provides. Over time, the exoskeleton aligns its movements with the unique gait of the person wearing it. In this study, the research team used a hip exoskeleton, which provides torque at the hip joint — in other words, adding power to help stroke survivors walk or move their legs more easily.

Taking Smarter Steps

Walking after a stroke can be tough and unpredictable. A patient’s stride can change from one day to the next, and even from one step to the next. Most exoskeletons aren’t built for that kind of variation. They are designed around the steady, even gait of healthy young adults, which can leave stroke survivors feeling more unsteady than supported.

Young’s breakthrough, detailed in IEEE Transactions on Robotics, is a neural network — a type of AI that learns patterns much like the human brain does. Sensors at the hip pick up how someone is moving, and the network translates those signals into just the right boost of power to support each step. It quickly figures out a person’s unique walking pattern. But lead clinician Kinsey Herrin said the AI’s learning doesn’t stop there. It keeps adjusting as the patient walks, so the exoskeleton can stay in sync even during stride shifts.

“The speed really surprised us,” Young said. “In just one to two minutes of walking, the system had already learned a person’s gait pattern with high accuracy. That’s a big deal, to adapt that quickly and then keep adapting as they move.”

Tests showed the system was far more accurate than the standard exoskeleton. It reduced errors in tracking stroke patients’ walking patterns by 70%.

Young emphasized that this research is about more than metrics. “When you see someone able to walk farther without becoming exhausted, that’s when you realize this isn’t just about robotics — it’s about giving people back a measure of independence,” he said.

Adapting Anywhere

Every exoskeleton comes with its own set of sensors, so the data they collect can look completely different from one device to the next. A neural network trained on one machine often stumbles when it’s moved to another. To get around that, Young’s team designed software that works like a universal adapter plug — no matter what device it’s connected to, it converts the signals into a form the AI can use. After just 10 strides of calibration, the system cut error rates by more than 75%.

“The goal is that someone could strap on a device, and, within a minute, it feels like it was built just for them,” Young said.

A Step Toward the Future

While the study centered on stroke survivors, the implications are far broader. The same adaptive approach could support older adults coping with age-related muscle weakness, people with conditions like Parkinson’s or osteoarthritis, or even children with neurological disabilities. 
Young and his team are now running clinical trials to measure how well the AI-powered exoskeleton supports people in a wide range of everyday activities.

“There’s no such thing as an ‘average’ user,” Young said. “The real challenge is designing technology that can adapt to the full spectrum of human mobility.”

If Georgia Tech’s exoskeleton can rise to that challenge, the promise goes well beyond the lab. It could mean a world where technology doesn’t just help people walk — it learns to walk with them.

Inseung Kang, who holds a B.S., M.S., and Ph.D. from Georgia Tech, is the paper’s lead author and now an assistant professor of mechanical engineering at Carnegie Mellon University. He explained that the real promise is in what comes next. 

“We’ve developed a system that can adjust to a person’s walking style in just minutes. But the potential is even greater. Imagine an exoskeleton that keeps learning with you over your lifetime, adjusting as your body and mobility change. Think of it as a robot companion that understands how you walk and gives you the right assistance every step of the way.”

 
Aaron Young is affiliated with Georgia Tech’s Institute for Robotics and Intelligent Machines.

This research was primarily funded by a grant (DP2HD111709-01) from the National Institutes of Health New Innovator Award Program. 

 
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Michelle Azriel 
Senior Writer – Editor
Institute Communications
mazriel3@gatech.edu

Adipose Under Pressure: IMS Facilities Highlight

Biomedical Engineering graduate students work on their custom hydraulic press

Fat grafting is a potentially life-saving surgical technique, often used to fill and repair severe injuries. Also used in cosmetic treatments, the procedure works to move fat from one part of the body to another. Yet not all parts of fat tissue are helpful and can be damaged or even harmful when transplanted.

To improve fat grafting, a team of students from in the Master of Biomedical Innovation and Development (MBID) program in the Wallace H. Coulter Department of Biomedical Engineering used tools in IMS’s Materials Properties Characterization Facility (MPCF) to isolate and remove harmful fat tissue.

The team designed and machined a hydrostatic press in the MPCF for their research. This kind of press applies equal pressure from all directions, which is different from a hydraulic press that only pushes in one direction.

To build their hydrostatic press, they:

  • Drilled a hole into a block of aluminum
  • Filled that hole with liquid
  • Then pushed down on the liquid with a piston

This setup allowed them to apply over 36,000 pounds of force for 10 minutes using a special machine called a servohydraulic test frame.

Their results showed that applying this pressure to their samples would destroy the parts of the fat cells that weren’t needed, while keeping the important structural parts and healing factors. This made the fat tissue more consistent and could make it safer to use in surgeries.

Hydraulic press in the MPCF
 
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Amelia Neumeister | Research Communications Program Manager

The Institute for Matter and Systems

Why Do Big Oil Companies Invest in Green Energy?

A flare burns natural gas at an oil well on Aug. 26, 2021, in Watford City, N.D.

A flare burns natural gas at an oil well on Aug. 26, 2021, in Watford City, N.D. AP Photo/Matthew Brown

Some major oil companies such as Shell and BP that once were touted as leading the way in clean energy investments are now pulling back from those projects to refocus on oil and gas production. Others, such as Exxon Mobil and Chevron, have concentrated on oil and gas but announced recent investments in carbon capture projects, as well as in lithium and graphite production for electric vehicle batteries.

National oil companies have also been investing in renewable energy. For example, Saudi Aramco has invested in clean energy while at the same time asserting that it’s unrealistic to phase out oil and gas entirely.

But the larger question is why oil companies would invest in clean energy at all, especially at a time when many federal clean energy incentives are being eliminated and climate science is being dismantled, at least in the United States.

Some answers depend on whom you ask. More traditional petroleum industry followers would urge the companies to keep focused on their core fossil fuel businesses to meet growing energy demand and corresponding near-term shareholder returns. Other shareholders and stakeholders concerned about sustainability and the climate – including an increasing number of companies with sustainability goals – would likely point out the business opportunities for clean energy to meet global needs.

Other answers depend on the particular company itself. Very small producers have different business plans than very large private and public companies. Geography and regional policies can also play a key role. And government-owned companies such as Saudi Aramco, Gazprom and the China National Petroleum Corp. control the majority of the world’s oil and gas resources with revenues that support their national economies.

Despite the relatively modest scale of investment in clean energy by oil and gas companies so far, there are several business reasons oil companies would increase their investments in clean energy over time.

The oil and gas industry has provided energy that has helped create much of modern society and technology, though those advances have also come with significant environmental and social costs. My own experience in the oil industry gave me insight into how at least some of these companies try to reconcile this tension and to make strategic portfolio decisions regarding what “green” technologies to invest in. Now the managing director and a professor of the practice at the Ray C. Anderson Center for Sustainable Business at Georgia Tech, I seek ways to eliminate the boundaries and identify mutually reinforcing innovations among business interests and environmental concerns.

People march holding signs objecting to fossil fuels.

Protesters call for companies and international organizations to reduce their spending on fossil fuels. Kent Nishimura/Getty Images
 

Diversification and Financial Drivers

Just like financial advisers tell you to diversify your 401(k) investments, companies do so to weather different kinds of volatility, from commodity prices to political instability. Oil and gas markets are notoriously cyclical, so investments in clean energy can hedge against these shifts for companies and investors alike.

Clean energy can also provide opportunities for new revenue. Many customers want to buy clean energy, and oil companies want to be positioned to cash in as this transition occurs. By developing employees’ expertise and investing in emerging technologies, they can be ready for commercial opportunities in biofuels, renewable natural gas, hydrogen and other pathways that may overlap with their existing, core business competencies.

Fossil fuel companies have also found what other companies have: Clean energy can reduce costs. Some oil companies not only invest in energy efficiency for their buildings but use solar or wind to power their wells. And adding renewable energy to their activities can also lower the cost of investing in these companies.

Public Pressure

All companies, including those in oil and gas, are under growing pressure to address climate change, from the public, from other companies with whom they do business and from government regulators – at least outside the U.S. For example, campaigns seeking to reduce investment in fossil fuels are increasing along with climate-related lawsuits. Government policies focused on both mitigating carbon emissions and enhancing energy independence are also making headway in some locations.

In response, many oil companies are reducing their own operational emissions and setting targets to offset or eliminate emissions from products that they sell – though many observers question the viability of these commitments. Other companies are investing in emerging technologies such as hydrogen and methods to remove carbon dioxide from the atmosphere

Some companies, such as BP and Equinor, have previously even gone so far as rebranding themselves and acquiring clean energy businesses. But those efforts have also been criticized as “greenwashing,” taking actions for public relations value rather than real results.

A net containing fish is pulled aboard a fishing vessel.

Fishing, like energy production, does not have to be done in ways that damage the environment. Thomas Barwick/DigitalVision via Getty Images
 

How Far Can This Go?

It is even possible for a fossil fuel company to reinvent itself as a clean energy operation. Denmark’s Orsted – formerly known as Danish Oil and Natural Gas – transitioned from fossil fuels to become a global leader in offshore wind. The company, whose majority owner is the Danish government, made the shift, however, with the help of significant public and political support.

But most large oil companies aren’t likely to completely reinvent themselves anytime soon. Making that change requires leadership, investor pressure, customer demand and shifts in government policy, such as putting a price or tax on carbon emissions.

To show students in my sustainability classes how companies’ choices affect both the environment and the industry as a whole, I use the MIT Fishbanks simulation. Students run fictional fishing companies competing for profit. Even when they know the fish population is finite, they overfish, leading to the collapse of the fishery and its businesses. Short-term profits cause long-term disaster for the fishery and the businesses that depend on it.

The metaphor for oil and gas is clear: As fossil fuels continue to be extracted and burned, they release planet-warming emissions, harming the planet as a whole. They also pose substantial business risks to the oil and gas industry itself.

Yet students in a recent class showed me that a more collective way of thinking may be possible. Teams voluntarily reduced their fishing levels to preserve long-term business and environmental sustainability, and they even cooperated with their competitors. They did so without in-game regulatory threats, shareholder or customer complaints, or lawsuits.

Their shared understanding that the future of their own fishing companies was at stake makes me hopeful that this type of leadership may take hold in real companies and the energy system as a whole. But the question remains about how fast that change can happen, amid the accelerating global demand for more energy along with the increasing urgency and severity of climate change and its effects.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

 
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Author:

Michael Oxman, Professor of the Practice of Sustainable Business, Georgia Institute of Technology

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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Molecular ‘Fossils’ Offer Microscopic Clues to the Origins of Life – But They Take Care to Interpret

ATP synthase is an enzyme that has been using phosphate to generate life’s energy for millions of years.

ATP synthase is an enzyme that has been using phosphate to generate life’s energy for millions of years. Nanoclustering/Science Photo Library via Getty Images

The questions of how humankind came to be, and whether we are alone in the universe, have captured imaginations for millennia. But to answer these questions, scientists must first understand life itself and how it could have arisen.

In our work as evolutionary biochemists and protein historians, these core questions form the foundation of our research programs. To study life’s history billions of years ago, we often use clues called molecular “fossils” – ancient structures shared by all living organisms.

Recently, we discovered that an important molecular fossil found in an ancient protein family may not be what it seems. The dilemma centers, in part, on a simple question: What does it mean if a simple molecular structure – the fossil – is found in every single organism on Earth? Do molecular fossils point to the seeds that gave rise to modern biological complexity, or are they simply the stubborn pieces that have resisted erosion over time? The answers have far-reaching implications for how scientists understand the origins of biology.

Follow the Phosphorus to Follow Life

Life is made of many different building blocks, one of the most important of which is the chemical element phosphorus. Phosphorus makes up part of your genetic material, powers complex metabolic reactions and acts as a molecular switch to control enzymes.

Phosphorus compounds – specifically a charged form called phosphate – have a number of unique chemical properties that other biological compounds cannot match. In the words of the pioneering organic chemist F.H. Westheimer, they are chemically able to “do almost everything.”

Their unique combination of stability, versatility and adaptability is why many researchers argue that following phosphorus is key to finding life. The presence of phosphorus both close to home – in the ocean or on one of Saturn’s moons – and in the farthest reaches of our galaxy is strong evidence for the potential for life beyond Earth.

Chemical structure of a nucleotide, made of a phosphate, ribose sugar and base

Phosphate is part of many essential biological molecules, including the building blocks of DNA. Charles Molnar and Jane Gair, CC BY-SA

If phosphorus is so critical to life, how did early biology predating cells first use it?

Today, biological organisms are able to make use of phosphates through proteins – molecular machines that regulate all aspects of life. By binding to proteins, phosphates regulate metabolism and cellular communication, and they serve as a source of cellular energy.

Further, the process of phosphorylation, or adding a phosphate group to a protein, is ubiquitous in biology and allows proteins to perform functions their individual building blocks cannot. Without proteins, the existence of organisms such as bacteria and humans may not be possible.

Given how essential phosphorus is to life, scientists hypothesize that phosphate binding was among the first biological functions to emerge on Earth. In fact, current evidence suggests that the first phosphate-binding proteins are truly ancient – even older than the last universal common ancestor, the hypothetical mother cell to all life on Earth that existed around 4 billion years ago.

A Mysterious Phosphate-Binding Fossil

One family of phosphate-binding proteins, called P-loop NTPases, regulates everything from the communication between cells to the storage of energy and are found across the tree of life. Because P-loop NTPases are among the most ancient protein families, analyzing their properties can provide key insights into both the emergence of proteins and how primitive life used phosphates.

Although P-loop NTPases are diverse in structure, they share a common motif called a P-loop. This component binds to phosphate by wrapping a nest of amino acids – the building blocks that make up proteins – around the molecule. Every known organism has multiple families of P-loop NTPase, which makes the P-loop an excellent example of a molecular fossil that can provide clues about the evolution of life. Our crude analysis of the human genome estimates that humans have about 5,000 copies of P-loops.

When part of a larger protein structure, the P-loop folds like origami into a shape that is ideal for hugging a phosphate molecule. These nests are extremely similar to each other, even when the surrounding proteins are only distantly related in function. A landmark study in 2012 argued that even if the P-loop nest is extracted from a protein, it can still bind to phosphate. In other words, the ability of a P-loop to form a nest is determined by its interactions with phosphate, not its protein scaffold.

This study provided the first evidence that some forms of the P-loop sequence could have functioned billions of years ago, even before the emergence of large, complex proteins. If true, this implies that P-loop nests may have seeded the emergence and evolution of many of the phosphate-binding proteins seen today.

Interrogating the History of the P-loop

The pioneer of bioinformatics, Margaret Oakley Dayhoff, hypothesized in 1966 that the large collection of big proteins seen today arose from small peptides that were duplicated and fused over long periods of time. Although P-loops may have evolved in a different way, Dayhoff’s realization was the first to clarify how complex forms could have arisen from much simpler ones.

Inspired by Dayhoff’s hypothesis, we sought to interrogate the role that simple P-loops may have played in the evolution of the complex proteins key to life. Our findings challenge what’s currently known about these molecular fossils.

Diagram showing the evolution of amino acids to oligopeptides to complex proteins

The Dayhoff hypothesis proposed that large, complex proteins arose from the duplication and merging of smaller, simpler peptides over time. Merski et al./Biomolecules, CC BY-SA

Using computer models, we compared a range of P-loops from the P-loop NTPase family to a control group made of the same amino acids but in a different order. While these control loops are also found in proteins, they do not form nests.

Although the P-loops and the control loops are very different in their nest-forming ability, we found that they both are able to form transient nests when embedded in proteins. This meant that, contrary to popular belief, the amino acid sequence of P-loops aren’t special in their ability to form nests – as would be expected if they alone were the seeds for many modern proteins.

A Fossil Eroded Over Time

Our work strongly suggests that while the P-loop is a molecular fossil, the true nature of its form billions of years ago may have been eroded by the sands of time.

For example, when we repeated our simulations in a different solvent – specifically methanol – we found that P-loops situated in their parent proteins were able to regain some of their ability to form nests. This doesn’t mean that being in methanol drove the first proteins with P-loops to form the nests critical for life. But it does emphasize the importance of considering the surrounding environment when studying peptides and proteins.

Just as archaeologists know to be careful in how they interpret physical fossils, historians of protein evolution could take similar care in their interpretation of molecular fossils. Our results complicate the current understanding of early protein evolution and, consequently, some aspects of the origins of life.

In resetting the field’s broader understanding of how these crucial proteins emerged, scientists are poised to start rewriting our own evolutionary history on this planet.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

 
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Authors:

Caroline Lynn Kamerlin, professor of chemistry and biochemistry, Georgia Institute of Technology 

Liam Longo, specially appointed associate professor, Earth-Life Science Institute, Institute of Science Tokyo

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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

New Links in Air Pollution and Dementia

Car exhaust (Adobe: elcovalana)

Scientists at Georgia Tech have teamed up with researchers at Johns Hopkins Medicine and Columbia University to better understand how certain types of air pollution increase the risk of developing dementia. 

Their findings, published this month in the journal Science, help explain how small particle pollution — think industrial emissions and car exhaust, wildfires and burning wood for heat and cooking — can lead to Lewy body dementia, a devastating disease that causes toxic clumps of protein to destroy nerve cells in the brain. 

"Epidemiological studies have suggested a strong link between air pollution and dementia, but what sets this study apart is that we also provide a convincing biological mechanism,” says Pengfei Liu, assistant professor School of Earth and Atmospheric Sciences and one of the study’s co-authors. “This collaborative work shows that fine particulate matter from different geographic regions consistently triggers a specific stain of misfolded protein that drives Lewy body dementia." 

The work has “profound implications” for helping scientists and policy makers better understand measures to prevent this type of dementia, which is among the most common forms of the disease and affects millions of people around the world.

Along with Liu, the research team from Georgia Tech includes Rodney Weber, professor in the School of Earth and Atmospheric Sciences; Minhan Park, a postdoctoral research fellow co-advised by Liu and Weber; Bin Bai, a graduate student in Liu’s lab; and Ma Cristine Faye Denna, a graduate student in Weber’s lab.

“Figuring out how exposure to atmospheric aerosols might be linked to dementia, and what mechanisms are involved, is a complex and challenging problem — and as this study shows, it takes a large team with many different areas of expertise,” Weber adds.

Learn more:

 

 
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Jess Hunt-Ralston
Director of Communications
College of Sciences at Georgia Tech

Georgia Tech Taps Military Talent to Boost Manufacturing Workforce

Lukas Berg (right), who flew several variants of the UH-60 Blackhawk over the course of his career, celebrated his final flight before joining the Georgia Tech Manufacturing Institute in August.

Lukas Berg (right), who flew several variants of the UH-60 Blackhawk over the course of his career, celebrated his final flight before joining the Georgia Tech Manufacturing Institute in August.

As the U.S. works to strengthen its industrial base and reshore critical manufacturing capabilities, workforce development has emerged as a central challenge — and opportunity. 

The Georgia Tech Manufacturing Institute (GTMI) recently welcomed its first Hiring Our Heroes (HOH) Fellow to help address this growing need. Lukas Berg, a retiring U.S. Army officer, will be working with GTMI to support new education and training programs aimed at preparing Georgians for careers in advanced manufacturing.

“Lukas Berg brings a unique blend of operational experience, academic insight, and a deep commitment to service,” said Thomas Kurfess, executive director of GTMI. “His perspective will be invaluable as we work to build stronger connections between Georgia’s communities and the advanced manufacturing sector.”

Hiring Our Heroes is a nationwide initiative led by the U.S. Chamber of Commerce Foundation that helps veterans and military spouses transition into civilian careers through short-term fellowships. Since 2021, Georgia Tech has hosted more than two dozen HOH fellows, beginning with U.S. Army veteran Erik Andersen, who now serves as interim deputy director for the Research, Electronics, Optics, and Systems Directorate at the Georgia Tech Research Institute (GTRI), where he also helps lead the HOH program. 

Berg is the first fellow to be placed outside of GTRI, a sign of the program’s growing reach across campus and its potential to support a broader range of workforce development efforts.

“It’s been exciting to see how the Hiring Our Heroes program has grown at Georgia Tech,” said Andersen. “Berg’s placement at GTMI reflects the Institute’s commitment to connecting military talent with real-world innovation and workforce development. Veterans bring a unique perspective and skill set to these challenges, and I’m proud to see the program expanding to new parts of campus.”

Berg’s military career includes aviation command roles, teaching positions at West Point and the Joint Special Operations University, and deployments across multiple regions. At GTMI, he will be contributing to a new initiative that partners with rural school districts to introduce students to hands-on learning in advanced manufacturing, an effort designed to spark interest in high-potential career paths and support long-term workforce readiness.

With personal ties to Georgia Tech and a strong sense of purpose, Berg sees this fellowship as a meaningful next step. We spoke with him to learn more about what brought him to GTMI and how he views the role of manufacturing and workforce development in shaping the country’s future.

What inspired you to pursue a fellowship at the Georgia Tech Manufacturing Institute after your military service?

Last year, I visited Georgia Tech with many of the junior officers and pilots assigned to my helicopter battalion in Savannah. Our agenda included stops at the Georgia Tech Manufacturing Institute and the Advanced Manufacturing Pilot Facility, both of which struck me as being absolutely vital to maintaining the technological edge required to fight and win on the modern battlefield. Pursuing a fellowship at GTMI felt like a natural extension of my military service, and I suspected that it would put me back at the intersection of thinkers and doers (where I have always felt most at home). 

You mentioned your grandmother taught at Georgia Tech for over 30 years — how has her legacy influenced your academic and professional journey?

My grandmother, Maria Venable, was the first woman to serve as a full-time faculty member in Georgia Tech’s School of Modern Languages. She poured herself into both her family and her students, and I was lucky to count myself in both populations, as she agreed to tutor me for the AP German exam in high school (but only if I behaved as well as her students at Tech). Her example inspired me to pursue a teaching assignment at West Point halfway through my Army career, and I experienced the same joy in teaching that she did. It’s something that I will continue to do for the rest of my life, whether in a formal or informal capacity.

Can you share more about the specific initiatives you'll be working on at GTMI related to advanced manufacturing education?

Most immediately, I am joining a new GTMI initiative that partners with rural school districts to deliver several weeks’ worth of curriculum and hands-on practice in advanced manufacturing. We just kicked off a pilot program with Bainbridge High School in Decatur, and it’s exciting to see their students leveraging sophisticated systems to design and build Pinewood Derby cars that would make Cub Scouts across the country green with envy. Beyond this initiative, I hope to contribute to other efforts that get young people excited about careers in manufacturing and that assist adult learners in re-skilling and up-skilling for this high-potential industry.

What are you most looking forward to as you begin your fellowship at GTMI?

Georgia Tech feels like a physical and intellectual crossroads of modern civilization. I’m excited to not only contribute as a member of GTMI but also to learn about the countless other departments, institutes, and programs that are convening talent to solve the world’s thorniest problems. 

What skills or insights are you hoping to gain during your time at GTMI that will support your next career chapter?

As an Army officer, I’ve been stationed across the country and deployed around the world, but Georgia has always been home. (Gladys Knight’s “Midnight Train to Georgia” has been a fixture on my playlist since I left for West Point at the age of 17.) Now back with my family, I look forward to using my time at GTMI to learn about my home state and identify ways that I can contribute to its near and long-term prosperity, whether through roles in academia, government, or private industry. I also look forward to expanding my network in all these communities, as no single one has a monopoly on problem-solving.

Why do you believe rebuilding America’s industrial base and manufacturing workforce is critical to national security today?

As a career aviator, much of my professional life was spent agonizing over the availability of parts to repair my helicopters. It seemed like there were never enough, and they always took too long to get to me. This experience, coupled with lessons learned from our support of Ukraine’s self-defense, contrasted starkly with my recent study of America’s 20th-century role as the “arsenal of democracy.” I’m convinced that we need to regain that reputation, and I would like to see Georgia at the forefront of associated design, manufacturing, and education initiatives.  

How do you see veterans playing a unique role in strengthening the U.S. manufacturing workforce?

I think veterans are the most natural candidates in the world for roles in the manufacturing workforce. They possess the knowledge, skills, and abilities to be successful in most endeavors, but most are looking for ways to extend their service beyond their time in uniform. What better way than to contribute to a field that is so vital to our national security and prosperity?

What does “Progress and Service” mean to you, and what does it mean to you personally to be contributing to that mission?

I love Tech’s motto. I grew up in a family and community that reinforced at every turn the idea that our highest potential as human beings is realized when we serve others. This motivated my choice to serve in the military for the past 20 years, and it remains my North Star for this next chapter. I also love the idea of technological progress being the vehicle by which Georgia Tech collectively serves others, and I hope to accelerate this progress during my time at GTMI. 

If you could give one piece of advice to other service members considering a fellowship like this, what would it be?

Inventory your passions and define your purpose. Then start reaching out to people in related fields. I have been amazed at how generous people have been with their time and how eager they have been to help me find my second calling and related opportunities.

Berg will be working with GTMI for the course of his fellowship with the Hiring Our Heroes program.

Berg will be working with GTMI for the course of his fellowship with the Hiring Our Heroes program.

Maria Venable, Berg's grandmother, joined the Georgia Tech faculty in 1963 as a 28-year-old native German speaker.

Maria Venable, Berg's grandmother, joined the Georgia Tech faculty in 1963 as a 28-year-old native German speaker.

Berg and his family stand next to the model of helicopter frequently flown during his career.

Berg and his family stand next to the model of helicopter frequently flown during his career.

 
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Audra Davidson
Research Communications Program Manager
Georgia Tech Manufacturing Institute

Meet the Microbes: What a Warming Wetland Reveals About Earth’s Carbon Future

An arial photo of the SPRUCE experiment.

An arial photo of the SPRUCE experiment.

Between a third and half of all soil carbon on Earth is stored in peatlands, says Tom and Marie Patton Distinguished Professor Joel Kostka. These wetlands — formed from layers and layers of decaying plant matter — span from the Arctic to the tropics, supporting biodiversity and regulating global climate.

“Peatlands are essential carbon stores, but as temperatures warm, this carbon is in danger of being released as carbon dioxide and methane,” says Kostka, who is also the associate chair for Research in the School of Biological Sciences and the director of Georgia Tech for Georgia’s Tomorrow. Understanding the ratio of carbon dioxide to methane is critical, he adds, because while both are greenhouse gasses, methane is significantly more potent.

Kostka is the corresponding author of a new study unearthing how and why peatlands are producing carbon dioxide and methane. 

The research, “Northern peatland microbial communities exhibit resistance to warming and acquire electron acceptors from soil organic matter,” was published this summer in Nature Communications, and was led by co-first authors Borja Aldeguer-Riquelme, a postdoctoral research associate in the Environmental Microbial Genomics Laboratory, and Katherine Duchesneau, a Ph.D. student in the School of Biological Sciences.

The study builds on a decade of research at the Oak Ridge National Lab’s Spruce and Peatland Responses Under Changing Environments (SPRUCE) experiment, a long-term research project in Minnesota that allows researchers to warm whole sections of wetland from tree top to bog bottom.

“Over the past 10 years, we’ve shown that warming in this large-scale climate experiment increases greenhouse gas production,” Kostka says. “But while warming makes the bog produce more methane, we still observe a lot more CO2 production than methane. In this paper, we take a critical step towards discovering why — and describing the mechanisms that determine which gases are released and in what amounts.”

Methane mystery

The subdued methane production in peatlands has been a long-standing mystery. In water-saturated wetlands, oxygen is scarce, but microbes still need to respire — a type of ‘breathing’ that allows them to produce energy for metabolic function. Without oxygen, microbes use nitrate, sulfate, or metals to respire — still releasing carbon dioxide in the process. However, if these ingredients aren’t present, microbes ‘breathe’ in a way that releases methane.

Since nitrate, sulfate, and metals are relatively rare in peatlands, methane production should be the most likely pathway, but surprisingly, observations show the opposite. “In both fieldwork and lab experiments, peatlands produce much more carbon dioxide than methane,” Kostka explains. “It’s puzzling because the soil conditions should help methane production dominate.”

To solve this mystery, the team leveraged a suite of cutting-edge genetic tools called “omics” —  metagenomics (studying DNA), metatranscriptomics (studying RNA), and metabolomics (a technique used to study the “leftovers” of metabolism), providing a detailed look under the hood of the microbial “engine” that cycles organic matter in wetlands. It also gave a new window into the diversity of soil microbes in wetlands: 80 percent of the organisms identified in the study were new at the genus level.

‘Omics’ innovations

Over the course of several years, the team collected samples from a peatland enclosed in an experimental chamber that was slowly warmed, then analyzed the samples using omics to see how they changed. Initially, they hypothesized that warming the soil would cause microbial communities to change quickly. “Microbes can evolve and grow rapidly,” Kostka says. “But that didn’t happen.”

The DNA-based methods showed that while the microbial communities stayed largely stable, the bog did release more greenhouse gasses as it warmed. To assess the metabolic potential of the microbes, Duchesneau and Aldeguer-Riquelme constructed microbial genomes, investigating how they were decomposing the organic matter in peatlands and cycling carbon.

“We found that microbial activity increases with warming, but the growth response of microbial communities lags behind these changes in physiological or metabolic activity,” Kostka says. He cautions that this doesn’t necessarily mean that wetland communities won’t change as climates warm — just that these shifts might come behind metabolic ones. 

A diversity of discoveries

And the methane? The team believes that microbes may be breaking down organic matter to access the key ingredients for producing carbon dioxide — nitrate, sulfate, and metals — though more research is currently underway to investigate this.

“Doing this type of integrated omics research in soil systems is still incredibly difficult,” Kostka says. The challenge is multifaceted: the research leverages years of experiments, long-term datasets, advanced laboratory techniques, and fieldwork innovations. 

At SPRUCE, experimental chambers are about 1,000 square feet. While it’s an impressive experimental setup, researchers still must be careful: “We need to take soil samples for many years, so if we take too many, there’d be no soil left!” Kostka explains. “Part of our research involves developing better, non-destructive sampling techniques.”

The other challenge lies in what makes these peatlands so unique: it’s very hard to detect small changes because of the sheer diversity of organisms present. “Every time we conduct this type of research, we learn more about these incredible systems,” he says. “There’s always something new.”

Postdoctoral Researchers Caitlin Petro and Borja Aldeguer-Riquelme inside a SPRUCE chamber in 2023.

Postdoctoral Researchers Caitlin Petro and Borja Aldeguer-Riquelme inside a SPRUCE chamber in 2023.

Ph.D. student Katherine Duchesneau sampling porewater inside an experimental SPRUCE chamber.

Ph.D. student Katherine Duchesneau sampling porewater inside an experimental SPRUCE chamber.

Postdoctoral Researcher Caitlin Petro, PhD student Katherine Duchesneau, and undergraduate student Sekou Noble-Kuchera in a SPRUCE chamber.

Postdoctoral Researcher Caitlin Petro, PhD student Katherine Duchesneau, and undergraduate student Sekou Noble-Kuchera in a SPRUCE chamber.

Joel Kostka at SPRUCE.
 
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Written by Selena Langner