The questions that keep us up at night are: How does the immune system present and recognize antigens to combat disease? What are the molecular features involved in stimulating robust and specific immune responses? How can we exploit distinct features of immune recognition to develop new treatments for disease? Our research centers on answering these important questions. We focus on the CD1 family of major histocompatibility complex class I (MHC-I) related proteins, which present both self and foreign lipids to αβ, γδ, and natural killer T cells. Examples of CD1 complexes involved in the adaptive and innate immune response to human disease include those associated with lipids derived from cancerous cells (Leukemia, Carcinoma, Lymphoma, Melanoma), wasp/bee venom including yellowjackets of the genus Vespula who represent Georgia Tech's mascot Buzz (Hymenoptera venom allergy), bacterial pathogens (Mycobacterium tuberculosis - Tuberculosis, Borrelia burgdorferi - Lyme Disease, Pseudomonas aeruginosa - Pneumonia), viral pathogens (HSV-1 - Herpes, HBV - Hepatitis B), marine sponges, and self cells in autoimmune disease (Dermatitis, Psoriasis, Lysosomal Storage Disease). Recent studies have shown that CD1 can also associate with and present a much broader range of antigens, such as skin oils that lack a discernible hydrophilic head group, lipopeptides, and non-lipid small molecules. Unlike peptide antigen presentation by high polymorphic human MHC-I complexes for which therapeutics must be tailored to a patients genetic background, the non-polymorphic nature of CD1 means that lipid/CD1 molecules are attractive candidates for donor-unrestricted (i.e. universal and patient-haplotype independent) vaccines and immunotherapy treatments. Progress in the development of lipid/CD1 mediated therapies has been hindered by an incomplete understanding in several important features of the CD1 antigen processing and presentation pathway as well as a lack of structural information for clinically relevant lipid/CD1 complexes. We aim to address these knowledge gaps with our research.
 

Prof. Ethier was originally trained as a mechanical engineer, receiving his Ph.D. from MIT in 1986 working in the lab of Roger D. Kamm. He then joined the University of Toronto, where he was a Professor of Bioengineering, Mechanical Engineering and Ophthalmology, and latterly the Director of the Institute of Biomaterials and Biomedical Engineering. Prior to joining Georgia Tech/Emory, Professor Ethier was the Head of the Department of Bioengineering at Imperial College, London from 2007-12. 

His research is in the biomechanics of cells and whole organs. His specific research topics include glaucoma (biomechanics of aqueous humour drainage in the normal and glaucomatous eye, and the mechanical and cellular response of optic nerve tissues to intraocular pressure), study of hemodynamic basis of arterial disease.

Sheng Dai, Ph.D., P.E., earned his degrees from Tongji University and Georgia Tech. He worked as an ORISE postdoc at the National Energy Technology Laboratory of the U.S. Department of Energy, and returned to Georgia Tech as a faculty member in 2015. He is currently an associate professor in the School of Civil and Environmental Engineering, Ocean Science and Engineering. and holds a courtesy appointment at the School of Earth and Atmospheric Sciences at Georgia Tech.

Dr. Dai's group addresses emerging energy and environment challenges through studying subsurface geomechanics, geomaterials characterization, energy geotechnics, bio-inspired geotechnics, flow in porous media, and granular dynamics. His research has been funded by federal funding agencies (DOE, NSF, NASA, DOT), national labs (INL, NETL), and industry (AECOM, GTI, Leidos).  Dr. Dai has been recognized for his research and teaching, including being a recipient of the NSF CAREER award, the ORISE Fellowship, the Bill Schutz Junior Faculty Teaching Award, and the Class of 1969 Teaching Fellows at Georgia Tech.

He is an associated editor of the Journal of Geophysical Research: Solid Earth and Advances in Geo-Energy Research, an editorial advisor of Geomechanics for Energy and Environment, and serves on the Pressure Core Advisory Board for U.S. Geological Survey, the GOM2 Marine Test Technical Advisory Committee for UT/DOE, the National Gas Hydrate Program for NETL, and the Task Force Leader of TC308 Energy Geotechnics of ISSMGE. 

Julia Kubanek serves as Georgia Tech’s Vice President for Interdisciplinary Research and is a professor in the School of Biological Sciences and the School of Chemistry and Biochemistry. In this role, she oversees and supports interdisciplinary activities at Georgia Tech including the Interdisciplinary Research Institutes (IRIs); the Pediatric Technology Center (PTC), the Novelis Innovation Hub; the Center for Advanced Brain Imaging (CABI); and the Global Center for Medical Innovation (GCMI). She also partners across the institute on developing and advancing new research initiatives based on student and faculty interests, expertise, and societal need.

Kubanek has held several previous leadership roles at Georgia Tech, including Associate Dean for Research in the College of Sciences and Associate Chair in the School of Biological Sciences. She joined the faculty at Georgia Tech in 2001. Her areas of research interest include chemical signaling among organisms (especially in aquatic systems), natural products chemistry, metabolomics, chemical biology, and drug discovery. She has authored approximately 100 research articles on marine plankton and coral reef chemical ecology, and on the discovery, mechanism of action, and biosynthesis of marine natural products. She was awarded the NSF CAREER Award in 2002, the Presidential Early Career Award for Scientists and Engineers (PECASE) in 2004, and was elected Fellow of the American Association for the Advancement of Science (AAAS) in 2012. In 2016, she served as chair of the Gordon Research Conference in Marine Natural Products; since 2016, she has chaired the Scientific Advisory Board of the Max Planck Institute for Chemical Ecology. Kubanek received her B.Sc. in Chemistry from Queen’s University, Canada, in 1991 and her Ph.D. in at the University of British Columbia in 1998, and performed postdoctoral research at the University of California – San Diego and the University of North Carolina at Wilmington.

Dr. Alexandra Peister is an associate professor in the Biology Department at Morehouse College.

Dr. Susan S. Margulies leads the U.S. National Science Foundation’s Directorate for Engineering in its mission to transform our world for a better tomorrow by driving discovery, inspiring innovation, enriching education, and accelerating access. With an annual budget of nearly $800 million, the NSF’s Engineering Directorate provides over 40 percent of federal funding for fundamental research in engineering at academic institutions, and it distributes more than 1500 awards supporting research and education each year. Projects funded by the Engineering Directorate span frontier research to generate new knowledge, problem-driven research to identify new solutions to societal challenges, and application-driven research to translate discoveries to uses that benefit society.

In partnership with industry and communities across the nation, the NSF’s investments in engineering research and education lead to innovative technologies and sustainable impacts in health, agriculture, clean energy and water, resilient infrastructure, advanced manufacturing and communication systems, and many other areas. NSF support also builds the Nation’s workforce capacity in engineering and supports the diversity and inclusion of engineers at all career stages. Together, the NSF’s investments in engineering research and education enhance prosperity, equity and quality of life for all Americans.

Margulies joined the NSF as the assistant director for the Directorate for Engineering in August 2021 after leading the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University. While on detail at the NSF, she is a professor and Georgia Research Alliance Eminent Scholar at Georgia Tech and Emory. She received her B.S.E. in mechanical and aerospace engineering at Princeton University, her Ph.D. in bioengineering from the University of Pennsylvania, and post-doctoral training at the Mayo Clinic. She joined the faculty at the University of Pennsylvania in 1993 as an assistant professor, rising through the ranks to professor. In 2017 she became the first faculty member tenured in both the Georgia Institute of Technology and Emory University, and she was a department chair in both the college of engineering at Georgia Tech and Emory’s school of medicine. 

Margulies is internationally recognized for pioneering studies spanning the micro-to-macro scales and across species to identify mechanisms underlying brain injuries in children and adolescents and lung injuries associated with mechanical ventilation, leading to improved injury prevention, diagnosis and treatments. She has launched numerous training and mentorship programs for students and faculty, created institute-wide initiatives to enhance diversity and inclusion, and led innovative projects in engineering education. 

Margulies’ transdisciplinary scholarly impact has been recognized by her election as fellow of the American Society of Mechanical Engineers, the Biomedical Engineering Society, and the American Institute for Medical and Biological Engineering, and as a member of the National Academy of Engineering and the National Academy of Medicine.  

Dr. Hanjoong Jo is John and Jan Portman Professor in the Coulter Department of Biomedical Engineering (BME) at Georgia Tech and Emory University, and Professor of Medicine at Emory University. He is also the Associate Chair of Emory in BME Department. Upon graduation from Korea University, Dr. Jo received PhD under the co-mentorship of Professors John Tarbell (Chemical Engineering) and Ted Hollis (Physiology) at Pennsylvania State University in 1989. Following postdoctoral training in Jay McDonald Lab at Washington University in St. Louis and University of Alabama at Birmingham, he became Assistant Professor in Pathology and BME. Dr. Jo joined the BME Department at Georgia Tech and Emory University in 2000. He directs the Cardiovascular Mechanobiology and Nanomedicine lab. His lab studies how mechanical force associated with blood flow regulates vascular biology and cardiovascular disease, especially atherosclerosis, aortic valve (AV) calcification, and abdominal aortic aneurysms. He has published more than 150 peer-reviewed papers and edited two books. He developed the mouse model of atherosclerosis, known as partial carotid ligation model, induced by disturbed flow. His work led to the discovery of several genes (mechanosensitive genes and microRNAs) and epigenetic controlling mechanisms that are regulated by bad blood flow and play key roles in atherosclerosis and AAA. By targeting some of these mechanosensitive genes, his lab has been able to treat atherosclerosis and AAA in mice. His lab is now working on nanotechnologies to developing targeted gene and drug therapies in an effort to translate mouse studies toward clinical application. He is an elected fellow of American Institute of Medical and Biological Engineering, Biomedical Engineering Society, American Heart Association and American Physiological Society. He serves as associate editors and editorial board members of several cardiovascular and biomedical engineering journals including Scientific Reports, Circulation Research, Atherosclerosis Thrombosis Vascular Biology, Am J Physiology, Cell Molecular Bioengineering and Cardiovascular Engineering and Technology. He also has been serving as reviewers and chairs of study sections of the NIH, NSF, Veterans Administration and Am Heart Association. He also organized several international meetings, and in 2012, he served as the Chair of the Annual BME Society Meeting. He is also the founding President of Korean-American BME Society and Chairs of US-Korea Annual BMES Workshops since 2013. He has been a Distinguished Visiting Professor at Ewha Womans University and Chonbuk National University.

Dr. Nie received her B.S. degree in Biology from Peking University in China in 2002. In 2007, she received her Ph.D. in Cell Biology from the University of Alabama at Birmingham, where she worked on elucidating signaling pathways in vertebrate gastrulation movements. Thereafter, she conducted postdoctoral research in the laboratory of Marianne Bronner at California Institute of Technology. She joined Georgia Tech in Fall 2014.

Facundo was born in Buenos Aires, Argentina. He received his MSc in Chemistry from the College of Exact and Natural Sciences, Buenos Aires University in 1995 and his PhD in Analytical Chemistry from the same University, in 1999.  In August 2000, he joined the research group of Prof. Richard N. Zare in the Department of Chemistry at Stanford University.  His work focused on several aspects of Hadamard transform time-of-flight mass spectrometry with an emphasis on coupling this technique to capillary-format separation methods.  In 2002, he joined the group of Prof. Vicki Wysocki in the Department of Chemistry at the University of Arizona, to develop novel tandem mass spectrometers for gas-phase peptide ion studies. In 2004 he joined the School of Chemistry and Biochemistry at the Georgia Institute of Technology where he currently holds the position of Vasser-Woolley Endowed Professor in Bioanalytical Chemistry and Associate Chair for Research and Graduate Training. He is the author of over 185 peer-reviewed publications and numerous invited presentations at national and international conferences. He has received several awards, including the NSF CAREER award, the CETL/BP Teaching award, the Ron A. Hites best paper award from the American Society for Mass Spectrometry, and the Beynon award from Rapid Communications in Mass Spectrometry, among others. He serves on the editorial board of The Analyst and as an Associate editor for the Journal of the American Society for Mass Spectrometry. His current research interests include the field of metabolomics and the development of new ionization, imaging, machine learning and ion mobility spectrometry tools for probing composition and structure in complex molecular mixtures. In his (limited) free time, Facundo enjoys a number of activities that include camping with his family, rock climbing, paddling, archery, photography and ham radio.