A Flexible Lens Controlled By Light-Activated Artificial Muscles Promises to Let Soft Machines See

This rubbery disc is an artificial eye that could give soft robots vision. Corey Zheng/Georgia Institute of Technology

This rubbery disc is an artificial eye that could give soft robots vision. Corey Zheng/Georgia Institute of Technology

Inspired by the human eye, our biomedical engineering lab at Georgia Tech has designed an adaptive lens made of soft, light-responsive, tissuelike materials.

Adjustable camera systems usually require a set of bulky, moving, solid lenses and a pupil in front of a camera chip to adjust focus and intensity. In contrast, human eyes perform these same functions using soft, flexible tissues in a highly compact form.

Our lens, called the photo-responsive hydrogel soft lens, or PHySL, replaces rigid components with soft polymers acting as artificial muscles. The polymers are composed of a hydrogel − a water-based polymer material. This hydrogel muscle changes the shape of a soft lens to alter the lens’s focal length, a mechanism analogous to the ciliary muscles in the human eye.

The hydrogel material contracts in response to light, allowing us to control the lens without touching it by projecting light onto its surface. This property also allows us to finely control the shape of the lens by selectively illuminating different parts of the hydrogel. By eliminating rigid optics and structures, our system is flexible and compliant, making it more durable and safer in contact with the body.

Why it Matters

Artificial vision using cameras is commonplace in a variety of technological systems, including robots and medical tools. The optics needed to form a visual system are still typically restricted to rigid materials using electric power. This limitation presents a challenge for emerging fields, including soft robotics and biomedical tools that integrate soft materials into flexible, low-power and autonomous systems. Our soft lens is particularly suitable for this task.

Soft robots are machines made with compliant materials and structures, taking inspiration from animals. This additional flexibility makes them more durable and adaptive. Researchers are using the technology to develop surgical endoscopes, grippers for handling delicate objects and robots for navigating environments that are difficult for rigid robots.

The same principles apply to biomedical tools. Tissuelike materials can soften the interface between body and machine, making biomedical tools safer by making them move with the body. These include skinlike wearable sensors and hydrogel-coated implants.

three photos showing a rubbery disk held between two hands

This variable-focus soft lens, shown viewing a Rubik’s Cube, can flex and twist without being damaged. Corey Zheng/Georgia Institute of Technology

What Other Research is Being Done in This Field

This work merges concepts from tunable optics and soft “smart” materials. While these materials are often used to create soft actuators – parts of machines that move – such as grippers or propulsors, their application in optical systems has faced challenges.

Many existing soft lens designs depend on liquid-filled pouches or actuators requiring electronics. These factors can increase complexity or limit their use in delicate or untethered systems. Our light-activated design offers a simpler, electronics-free alternative.

What’s Next

We aim to improve the performance of the system using advances in hydrogel materials. New research has yielded several types of stimuli-responsive hydrogels with faster and more powerful contraction abilities. We aim to incorporate the latest material developments to improve the physical capabilities of the photo-responsive hydrogel soft lens.

We also aim to show its practical use in new types of camera systems. In our current work, we developed a proof-of-concept, electronics-free camera using our soft lens and a custom light-activated, microfluidic chip. We plan to incorporate this system into a soft robot to give it electronics-free vision. This system would be a significant demonstration for the potential of our design to enable new types of soft visual sensing.

The Research Brief is a short take on interesting academic work.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

 
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Authors:

Corey Zheng, PhD Student in Biomedical Engineering, Georgia Institute of Technology 

Shu Jia, Assistant Professor of Biomedical Engineering, Georgia Institute of Technology

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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Microsoft Removing Support for Windows 10 Could Increase E-Waste, Cybersecurity Threats

Windows device with a landfill in background

When Microsoft announced it was ending support for Windows 10 last week, about 40 percent of all Windows users faced limited options. 

While some of those users can upgrade to Windows 11, hundreds of millions of devices don’t meet the technical requirements. 

Those users might be wondering what else they can do besides throwing away their current device and buying a new one or risking running outdated software on it.

The tech conglomerate faced backlash from environmental and cybersecurity experts after informing Windows users that it would cease providing updates for Windows 10. 

These experts have warned that rendering hundreds of millions of devices practically useless will worsen the ever-growing problem with electronic waste (e-waste) and leave users who can't upgrade vulnerable to cybersecurity threats.

Researchers from Georgia Tech’s School of Interactive Computing (SIC) and School of Cybersecurity and Privacy (SCP) echo those concerns.

Forcing users to replace their devices means that up to 240 million old devices, according to one analysis, will inevitably end up in landfills.

“The problem of e-waste raises the question of why and how these technologies become obsolete,” said Cindy Lin, a Stephen Fleming Early Career Assistant Professor in SIC. 

Lin studies data structures and environmental governance in Southeast Asia and the U.S.

“Scholarship in human-computer interaction (HCI) on repair reveals that many of these technologies suffer from planned obsolescence,” she said. “This means that companies have designed products with a short lifespan, increasing consumption and waste simultaneously.”

When e-waste is dumped in landfills, the organic materials within devices decompose, producing methane, a potent greenhouse gas. And with every discarded device comes the need to produce new ones. The raw materials of these devices are mined, refined, and processed, consuming enormous amounts of energy through the burning of fossil fuels.

The Problem with Hackers

Though Microsoft said it will continue to provide Windows 10 security updates for one year, users are still being pressured to upgrade. By this time next year, if users still haven’t upgraded to Windows 11, they can expect to become easy targets for cyber criminals.

For example, users could receive phishing emails claiming to be from Microsoft about security updates from hackers pretending to be Microsoft. 

“The cybersecurity implications are very serious because new vulnerabilities of Windows 10 will go unpatched for a large part of the user base of this system,” said Mustaque Ahamad, Regents’ Entrepreneur Professor and interim chair of SCP.

“These users will become targets of hackers and cyber criminals who will be able to exploit these vulnerabilities. This will make these machines more prone to attacks such as ransomware and data exfiltration.”

What Can Users Do?

Buying a new device typically costs around $300 at the low end, while some gaming computers can exceed $2,500. 

Josiah Hester, an associate professor in the School of IC who researches computing and sustainability, said users who want to avoid discarding their devices can install Linux Mint, a free universal operating system.

“I would hope that instead of discarding, people might see this as an opportunity to go into a more open ecosystem like Linux Mint, which was designed for Windows users,” Hester said. 

“So much perfectly good hardware is obsolesced by force, when users are more than willing to give it a second life, either through ending support on the software side, subscription services that require certain versions of an OS, or even building the hardware or low-level functions that reduce the autonomy of device owners.” 

Linux Mint is open source and offers its own suite of software products, including a word processor. It also has a built-in security system. It requires 2GB of RAM, 20GB of disk space, and 1024x768 resolution to operate.

On a systemic level, Lin and Hester said people can support organizations that advocate for right to repair and legislation that protects consumers from planned obsolescence.

“HCI studies of informal economies of improvisation and repair have demonstrated that technologies have a longer lifecycle if we have access to expertise on how to repair them without facing penalties such as copyright violations,” Lin said.

“The ongoing right-to-repair movement in the US shows promise in making technology repairable and, in turn, more sustainable.”

 

Georgia Tech Launches Fall 2025 Lab Collaboration Dashboards

Tech Tower

Georgia Tech has launched the latest edition of its National Laboratory (NL) Collaboration Data Dashboards, covering fiscal years 2016–2025. The updated dashboards provide a sharper, data-driven view of Georgia Tech’s partnerships with the U.S. Department of Energy National Laboratories, offering insights into research impact, funding trends, and strategic opportunities for the campus community.

“This new edition goes beyond showcasing collaboration — it’s a strategic tool that helps researchers and administrators identify high-impact opportunities, optimize funding strategies, and plan future initiatives with precision,” said Vice President of Interdisciplinary Research Julia Kubanek.

What’s new in this release:

  • Recent Strategic Funding Insights: For the first time, dashboards detail NL funding awarded to Georgia Tech by publication discipline for calendar years 2023–2025, providing clear visibility into where investments are concentrated and where new opportunities may lie.
  • Mutual Research Investments: Georgia Tech’s collaborative projects with NLs now highlight reciprocal funding flows, reflecting shared priorities and strengthening partnerships that advance cutting-edge science and technology.
  • Research and Innovation Impact: From numerous joint publications and citations to patents cited by NLs, the dashboards demonstrate Georgia Tech’s leadership in advancing innovation across STEM disciplines.
  • Expanded Collaboration Areas: The dashboards spotlight high-impact research in advanced computing, synthetic biology, nanotechnology, cybersecurity, sustainability, advanced manufacturing, microelectronics, and energy solutions — underscoring how Georgia Tech-NL collaborations tackle pressing global challenges.

“National Lab collaborations are a cornerstone of Georgia Tech’s mission,” said Professor Martin Mourigal, Georgia Tech faculty liaison for Oak Ridge National Laboratory. “They give our students and faculty access to world-class infrastructure, specialized expertise, and mission-driven science that shape careers and drive discovery.”

“These dashboards are more than a record. They are a roadmap for strategic investment and collaboration that positions Georgia Tech to secure larger funding opportunities and accelerate innovation,” added George White, senior director of strategic partnerships.

The dashboards are live at research.gatech.edu/national-laboratories. The next update is scheduled for February 2026.

 
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Space Exploration in the Backyard, On a Budget – How NASA Simulates Conditions in Space Without Blasting Off

Analog missions, like those conducted at NASA’s CHAPEA facility at the Johnson Space Center, help scientists study human spaceflight without leaving Earth. Ronaldo Schemidt/AFP via Getty Images

Analog missions, like those conducted at NASA’s CHAPEA facility at the Johnson Space Center, help scientists study human spaceflight without leaving Earth. Ronaldo Schemidt/AFP via Getty Images

Humanity’s drive to explore has taken us across the solar system, with astronaut boots, various landers and rovers’ wheels exploring the surfaces of several different planetary bodies. These environments are generally hostile to human and equipment health, so designing and executing these missions requires a lot of planning, testing and technological development.

You may have heard about the extensive testing facilities for spacecraft and equipment, but how do scientists prepare for the human aspect of space exploration?

One way to test out techniques and identify situations that may arise during a real mission is using a simulation, which in this field is more commonly known as an analog. Researchers choose and design analog missions and environments to replicate elements of a real mission, using what is available here on Earth.

These missions are conducted in extreme environments on Earth that are comparable to the Moon or Mars, in habitats designed to replicate living quarters, or a combination of both. Researchers can use analogs to study crew performance and procedures, or to test instruments under development for use in space.

For example, operating a drill or wrench may seem easy here on Earth, but try doing the same task in thick gloves on a bulky, pressurized space suit in lower gravity. Suddenly, things aren’t so straightforward. Testing these scenarios on Earth allows researchers to identify necessary changes before launch. The analogs can also train crew members who will one day undertake the actual mission.

I’m a planetary scientist, which means I study the geology of other planets. Currently, I study environments on Earth that are similar to other planets to improve our understanding of their counterparts elsewhere in the solar system. I participated as a volunteer in one of these analog missions as an “analog astronaut,” serving as the crew geologist and applying my prior research findings from studying the surfaces of the Moon and Mars.

These analog missions vary in setting, length and intensity, but all aim to learn more about the human factors involved in space exploration.

Where Do We Send Them?

Analog missions are designed to simulate the crew’s experience in a given mission plan. In some cases, they simulate surface operations on the Moon or Mars for up to a year. Others might replicate the experience of being in transit to Mars for a period of time, followed by the crew “landing” and exploring the surface.

NASA uses several analog mission facilities spread across the world. For example, the Mars Desert Research Station in Utah is located in an environment chosen to imitate conditions on Mars, while analog missions at Aquarius, an undersea research station off the coast of Florida, help scientists learn about crew behavior and psychology in a confined habitat located in a hostile environment.

Some natural environments are commonly used for analog operations, such as volcanic terrains in the western U.S., human-made craters in Nevada, the natural meteor crater in Arizona and research stations in Antarctica. These locations mirror the geologic settings the crews are likely to encounter on future missions, and so training in these locations helps them execute the actual missions.

I participated in a simulated 28-day lunar surface mission at a facility called Hi-SEAS as part of a study on crew dynamics and psychology in extreme isolation. The facility is located on Mauna Loa, a volcano on the big island of Hawaii. This habitat has been used for a variety of studies, as the volcanic terrain is reminiscent of both the Moon and parts of Mars, and the isolated location simulates being in space.

A series of photos showing a dome-shaped habitat; a circular window; a circular doorway labeled 'airlock'; a room full of cabinets and appliances labeled 'laboratory'; a stairwell and elliptical; and a room with a small bed labeled 'cabins'

The HI-SEAS Habitat, which recreates the conditions of living and working on the Moon, is located in Mauna Loa, Hawaii. Jordan Bretzfelder

Analog Mission Crews

Most missions require applicants to hold relevant degrees. They must undergo physical health and psychiatric evaluations, with the goal being to select individuals with similar backgrounds to those in the astronaut corps. The ideal crew is typically made up of participants who work and live well with others, and can stay cool under stress.

Crews also include at least one person with medical training for emergencies, as well as a variety of scientists and engineers to operate the habitat’s life support systems.

Two photos of a group of people wearing flight suits walking in a volcanic terrain and standing in front of a geodesic dome.

Special suits were required whenever researchers left the habitat. They consisted of flight suits, protective pads, thick motorcycle gloves and a modified helmet with an air pump unit attached, housed in a backpack. Ensuring the suits and air systems were functioning before and during these short expeditions was critical. Jordan Bretzfelder

The experiences of each crew varies, depending on the mission design, location and makeup of the crew. My mission was designed so that the six crew members would not have any information about our crewmates until we arrived in Hawaii for training. In addition to geology expertise, I also have some medical training as a Wilderness First Responder, so I was there to assist with any medical issues.

Daily Life On An Analog Mission

Once in Hawaii, the crew spent three days learning how to operate the habitat systems, including the hydroponic garden and solar panels. We practiced emergency procedures and were taught how to perform other tasks.

After that orientation, we were deployed to the habitat for 28 days. We turned in our phones to mission control and could only access the internet to check emails or use a few preapproved websites required for our daily duties. Our days were scheduled with tasks from wake up, about 6:30 a.m., to lights out, about 10 p.m.

A mission patch showing three people wearing masks and flight suits and walking toward a dome-shaped habitat, with a ring around it saying 'Medulla IV' with the names of the participants.

The mission patch from the lunar analog mission.

The tasks included a variety of exercises to assess individual and group performance. They included individual assessments – similar to a daily IQ test – and group computer-based tasks, such as team 3D Tetris. The researchers remotely monitored our interactions during these activities, and the results were analyzed as the mission progressed. They used our fluctuating performance on these activities as a proxy for estimating stress levels, group cohesion and individual well-being.

Additionally, we went on two-to-three-hour extra-vehicular activities, or excursions outside the habitat, on alternating days. During these expeditions, we conducted geologic investigations on the volcano. On our “off days,” we spent two hours exercising in the habitat. We had to be fully suited in a mock spacesuit any time we went outside, and we had to be careful about the airlock procedures. We were never outdoors alone.

We could only eat freeze-dried and powdered foods, aside from what we were able to grow in the hydroponic system. We had no additional food delivered during our stay. Water was also rationed, meaning we had to find innovative ways to maintain personal hygiene. For example, a bucket shower one or two times per week was allowed, supplemented by “wilderness wipe” baths. As someone with a lot of very curly hair, I was happy to figure out a method for managing it using less than two liters of water per week. We were also permitted to do laundry once during our stay, as a group. Sorting through your crewmates’ wet clothes was certainly one way to bond.

Though physically demanding at times, the workload was not unreasonable. We were kept busy all day, as certain everyday tasks, such as cooking, required more effort than they might need in our normal lives. Preparing nutritionally balanced and palatable meals while rationing our very limited resources was hard, but it also provided opportunities to get creative with recipes and ingredients. We even managed to bake a cake for a crew member’s birthday, using peanut butter protein and cocoa powders to flavor it.

After dinner each night, we shared the pre-saved movies and shows we had each brought with us into the habitat, as we could not access the internet. Those of us who had brought physical copies of books into the habitat would trade those as well. One crew member managed to acquire a downloadable form of the daily Wordle, so we could still compete with our friends back home. We also played board games, and all of these activities helped us get to know each other.

Though different from our typical daily lives, the experience was one of a kind. We had the satisfaction of knowing that our efforts advanced space exploration in its own small way, one IQ test and slapdash cake at a time.The Conversation

 

This article is republished from The Conversation under a Creative Commons license. Read the original article.

 
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Jordan Bretzfelder, Postdoctoral Fellow, Earth and Atmospheric Sciences, Georgia Institute of Technology

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Shelley Wunder-Smith
shelley.wunder-smith@research.gatech.edu

Renato Monteiro Named 2025 John von Neumann Theory Prize Recipient

Renato Monteiro

Renato Monteiro, the Coca-Cola Chair and Professor in the H. Milton Stewart School of Industrial and Systems Engineering (ISyE) at Georgia Tech, has been awarded the 2025 John von Neumann Theory Prize, one of the highest honors in the fields of operations research and management sciences.

Monteiro has been a leading figure in continuous optimization for decades, recognized for combining deep theoretical advances with practical algorithm design that has shaped modern optimization. His pioneering work includes foundational contributions to interior-point methods, the influential Monteiro–Zhang framework for semidefinite programming, and the Burer–Monteiro method, which made it possible to tackle massive optimization problems across areas such as machine learning, data science, and engineering.

The John von Neumann Theory Prize, awarded annually by INFORMS, honors a scholar (or scholars in the case of joint work) whose body of research represents fundamental, sustained contributions to theory. Prize criteria include significance, innovation, depth, and scientific excellence, with emphasis on work that has stood the test of time. Named for the legendary mathematician John von Neumann, the prize commemorates his extraordinary contributions to mathematics, computing, and applied science. Von Neumann’s work on the stored program concept and the IAS computer laid the foundation for modern computing architecture. He also played a pivotal role in advancing computational methods for solving some of the most complex scientific and engineering challenges of his time.

“Dr. Monteiro’s work exemplifies the spirit of the John von Neumann Theory Prize,” INFORMS noted in its announcement. “His contributions combine mathematical depth with wide-reaching impact, influencing generations of researchers and practitioners.”

Monteiro will receive the award, which includes a $5,000 honorarium, a medallion, and a citation, during the INFORMS Annual Meeting award ceremony in Atlanta on Sunday, October 26, 2025.

 
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Flying Taxis Are Nearly Here — What’s Still Grounding Them

AI image of air taxis in futuristic setting

A new wave of aviation innovation is taking shape above our cities, where short flights in electric air taxis could complement cars and trains as part of everyday transportation. Known as advanced air mobility (AAM), this emerging industry aims to connect communities more efficiently while reducing emissions and noise.

Before these futuristic aircraft can take off, Georgia Tech researchers say there’s serious work to do — in the air, on the ground, and in policy.

Why Now? The Technology Is Catching Up

“The same battery and automation technologies we’re using in electric ground vehicles are now being scaled for aircraft,” said Laurie Garrow, professor in the School of Civil and Environmental Engineering and co-director of Georgia Tech’s Center for Urban and Regional Air Mobility. “We’re also seeing improvements in distributed propulsion and composite materials that make these aircraft lighter, quieter, and more efficient.”

Garrow cautions that widespread commercial service is years away. “We may see high-profile demonstrations soon, maybe even at global events like the Olympics, but aviation certification is a rigorous process. It takes time to earn public trust.”

Safety, Regulation, and Public Acceptance

The promise of AAM depends on more than aircraft design — it also requires new safety frameworks and public confidence.

“We’ll need to define what I call ‘roads in the sky’ — safe corridors where these aircraft can operate alongside traditional air traffic,” Garrow said. “And we’ll need to ensure certification standards, air traffic control, and pilot training evolve alongside technology.” 

Understanding how these vehicles interact with complex urban environments is essential to safe operation. Marilyn Smith, David Sloan Lews Professor in the School of Aerospace Engineering and director of the Vertical Lift Research Center of Excellence, leads research on modeling and simulation to prepare aircraft for real-world conditions.

Her lab is developing real-time simulations that factor in turbulence, wind shear, and other transient effects. “These predictions are not trivial,” Smith said. “We need fast, physics-based models that can run in near-real time to inform both design and regulation. There are significant and abrupt variations in the atmosphere that must be accounted for, both for passenger vehicles and smaller delivery drones.”

Smith’s team is also integrating artificial intelligence to improve speed and accuracy in certification — but always under expert oversight. “AI can accelerate our work,” she said. “Without the knowledge of domain experts, machine learning can generate misleading results, and that’s unacceptable when safety is on the line.”

Infrastructure, Airspace, and the Urban Puzzle

Even the most advanced aircraft cannot operate without new infrastructure on the ground and in the sky. 

Vertiports are needed to allow aircraft to take off and land vertically. Also required are “charging systems and robust fire safety protocols for high-energy batteries,” Garrow said. “And perhaps most critically, we need ‘rules of the road in the sky’ to manage air traffic around existing airports.”

Atlanta could offer a unique advantage. “The runways at Hartsfield-Jackson run east to west, while most of the metro population centers are north and south,” Garrow noted. “That natural separation could make it easier to integrate vertical takeoff and landing operations.”

Alex Oettl, professor in the Scheller College of Business, cautions that AAM’s benefits could concentrate in major hubs without inclusive planning. “Improved connectivity will raise productivity in ‘superstar cities,’ but we’ll need new strategies if we want to ensure smaller communities aren’t left behind,” he said.

China’s Head Start and What It Means for the U.S.

Oettl notes that China has surged ahead in AAM thanks to coordinated government action, flexible regulations, and significant infrastructure investment.

“In contrast, the U.S. and Europe face more stringent certification requirements,” Oettl said. “That slows deployment but ideally ensures stronger safety standards. It’s a tradeoff between innovation speed and risk management.”

Cities and companies that move first into AAM could shape standards and attract investment — but they also shoulder more risk. “There’s a danger of technological lock-in or stranded assets if early systems don’t scale or demand falls short,” Oettl said. “We’ve seen parallels before, like the scooter boom that left cities with thousands of idle vehicles.”

Looking Ahead: The Urban Sky 

For now, AAM remains on the horizon — visible but not yet within reach. Coordinated efforts between government, industry, and academia will determine how quickly it moves from prototype to daily reality.

“Georgia has been proactive in attracting aviation manufacturing,” Garrow said. “Coupled with our state’s infrastructure and Georgia Tech’s research ecosystem, we’re well positioned to lead.”

She added, “In aviation, we like to say we crawl, we walk, we run. These technologies are coming, but safely integrating them into our skies will take time, teamwork, and trust.”

 
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Researchers Discover Spontaneous Chirality in Conjugated Polymers

Tiny helices emerge during a phase separation process, offering clues about how life's building blocks may have first developed a preference for one 'handed' form over another. (Credit: Jong-Hoon Lee, Ziming Wang, Ying Diao)

Certain materials can spontaneously form spiral-shaped structures, even when they start out without any 'handedness.' These tiny helices emerge during a phase separation process, offering clues about how life's building blocks may have first developed a preference for one 'handed' form over another. (Credit: Jong-Hoon Lee, Ziming Wang, Ying Diao)

This story by Kristina Shidlauski is shared with the University of Illinois Urbana-Champaign newsroom. John R. Reynolds is a professor in the School of Chemistry and Biochemistry and School of Materials Science and Engineering at Georgia Tech. He served as founder of the Georgia Tech Polymer Network (GTPN) and is a member of the Center for Organic Photonics and Electronics (COPE).

Chirality, a property where structures have a distinct left- or right- “handedness,” allows natural semiconductors to move charge and convert energy with high efficiency by controlling electron spin and the angular momentum of light. A new study has revealed that many conjugated polymers, long considered structurally neutral, can spontaneously twist into chiral shapes. This surprising behavior, overlooked for decades, could pave the way for development of a new class of energy-efficient electronics inspired by nature.

The research, a collaborative project that included researchers from the University of Illinois Urbana-Champaign, Georgia Institute of Technology, University of North Carolina, and Purdue University was recently published in the Journal of the American Chemical Society.

“Many molecules essential to life are chiral,” said Ying Diao, professor of chemical and biomolecular engineering at Illinois, who led the project. “The question that has remained a really a big fascination across the field is how chiral symmetry breaking happens in the first place: that is how life selects one handedness over the other. Our work mainly focuses on the origin of chirality: why chirality spontaneously emerges in absence of any chiral sources.” 

To answer this question, the team tested 34 different conjugated polymers. Each polymer was dissolved in a solvent, then the researchers gradually increased the polymer concentration to observe whether liquid–liquid phase separation (LLPS) occurred. When LLPS was detected, they used circular dichroism spectroscopy to analyze the samples, revealing a strong correlation between phase separation and the emergence of chirality. The researchers refer to this phenomenon as spontaneous chiral symmetry breaking.

They found that approximately two-thirds of the polymers spontaneously formed chiral structures when their concentration in the solution increased.

“That took our community by surprise, because conjugated polymers have been studied for half a century,” Diao said. “These new chiral helical states of matter have basically been hiding in plain sight.”

To understand why some of the polymers developed chirality while others did not, Illinois chemistry professor and senior co-author Nicholas E. Jackson applied machine learning to analyze molecular features across the polymer library. The analysis, later backed up by additional testing, revealed that polymers with longer molecular chains were more likely to form chiral assemblies. Unexpectedly, the researchers also found that the presence of oxygen atoms in the side chains was a strong predictor of chiral behavior.

“Machine learning uncovered hidden patterns across dozens of conjugated polymers, relating subtle chemical details to chiral phase formation,” Jackson said. “Such insights would have been very difficult to derive by human intuition alone.”

Diao noted that the discovery not only deepens our fundamental understanding of chiral emergence but also holds significant technological promise. In nature, chiral systems – such as those involved in photosynthesis – enable highly efficient electron transport. Looking ahead, Diao said that mimicking this behavior could lead to major performance gains in electronic devices and innovation of new device types.

“We are thinking about using chirality to control conductivity – for example, in transparent conductors for phones or in solar cells that could be more stable and efficient,” she said. “In our computers, electrons bounce around and heat is a big problem. But if we make chiral versions, we think charge transfer could be extremely efficient, just like in nature.”

“What’s nice about this is, this is not the end of the story,” said Georgia Institute of Technology chemistry professor John Reynolds, a senior co-author on the study. “This work provides guidance to polymer scientists in the field for studying the many, many conjugated polymers that have been synthesized over the years, and for designing new polymers with enhanced properties.”

 

This study was supported by the U.S. Office of Naval Research, the Air Force Office of Scientific Research, the Molecule Maker Lab Institute, and the National Science Foundation. Polymers for the study were provided by Reynolds, University of North Carolina chemistry professor Wei You, University of Illinois chemistry professor Jeff Moore, and Purdue University chemistry professor Jianguo Mei.

In addition to her appointment in Chemical & Biomolecular Engineering, Diao is a full-time faculty member at the Beckman Institute for Advanced Science and Technology, holds a faculty appointment with Chemistry in the College of Liberal Arts & Sciences, and is affiliated with Materials Science & Engineering in The Grainger College of Engineering. In addition to his appointment in Chemistry, Jackson is a group leader at the Beckman Institute and affiliate faculty member in the departments of Chemical & Biomolecular Engineering and Materials Science & Engineering.

The paper, "Ubiquitous Chiral Symmetry Breaking of Conjugated Polymers via Liquid Liquid Phase Separation," is available online at https://pubs.acs.org/doi/abs/10.1021/jacs.5c07995

 
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To reach Ying Diao: yingdiao@illinois.edu

Cancer Atlas Offers a Roadmap to Detecting Tumors Earlier Than Ever

Illustration of cancer cells along a road with location markers next to each cell to represent the cancer "atlas" Gabe Kwong and his collaborators are building.

(Illustration: Sarah Collins)

When a Georgia Tech-led project received a contract award from the Advanced Research Projects Agency for Health (ARPA-H), it was for a bold idea with aggressive metrics. And it wasn’t guaranteed money. The team, led by biomedical engineer Gabe Kwong, had to deliver on its vision. Doing so could transform cancer screening and care, leading to one-size-fits-all tests that detect multiple cancers before they’re visible on CT or PET scans.

It’s a big goal, but that’s the point of ARPA-H. The agency funds staggeringly difficult healthcare innovation ideas that require major investment to succeed.

Two years into the $49.5 million project, Kwong and the team from Georgia Tech, Columbia University, and Mount Sinai Health System has crossed a critical threshold.

They’ve built the first tool able to measure enzyme activity around cancer tumors and healthy cells. And they’ve deployed it to understand the unique signatures for tumors from 14 different kinds of cancer.

That data is powering the first version of a cancer “atlas.” Like a geographical atlas, it will offer directions to each kind of tumor, allowing scientists to design sensors that follow the map and detect cancer tumors when they’re still small.

“If I want to deliver a sensor to a particular region inside the body, right now, there's no way of directing it. We give it systemically, and it basically infuses all tissues all the time,” said Kwong, Robert A. Milton Professor in the Wallace H. Coulter Department of Biomedical Engineering. “What's powerful is that we’re now defining tissue sites with a specific molecular ‘barcode.’ Then if a sensor is given systemically, it should only turn on when the barcode matches the local tissue.”

Read more about the project on the College of Engineering website.

 
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Low Frequency Radio Lab Trio Go to Alaska for Atmospheric Research

HAARP in Alaska

Home to some of the best geophysical research facilities in the country, Alaska is a premier destination for scientific exploration. It’s become a popular destination for Georgia Tech students and researchers, especially those in Professor Morris Cohen’s Low Frequency Radio Lab.

School of Electrical and Computer Engineering (ECE) Ph.D. students Gus Richter, Malhar Tamhane, and Felipe Sandoval are the latest to make the trip to the “Last Frontier” as they work to push the boundaries of atmospheric research. The trio participated in the 2025 Polar Aeronomy and Radio Science (PARS) summer school program held in August at the University of Alaska Fairbanks and the High-frequency Active Auroral Research Program (HAARP).

Read the full story on the School of Electrical and Computer Engineering's website.

 
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Mapping Evolution: James Stroud Named 2025 Packard Fellow

Although the sensors weigh just three-hundredths of a gram each — the same as a single grain of rice — when combined with innovations in mapping technology, they will help Stroud observe the lizards as active participants in their species’ evolution.

Although the sensors weigh just three-hundredths of a gram each — the same as a single grain of rice — when combined with innovations in mapping technology, they will help Stroud observe the lizards as active participants in their species’ evolution.

James Stroud has been named a 2025 Packard Fellow for his pioneering research in evolutionary biology. Stroud, Elizabeth Smithgall-Watts Early Career Assistant Professor in the School of Biological Sciences, will receive $875,000 over five years to fund his work on “Lizard Island” in South Florida. His goal? To create evolution’s first high-definition map — with the help of 1,000 backpack-wearing lizards.

Awarded annually to just 20 individuals by the David and Lucile Packard Foundation, Packard Fellowships for Science and Engineering support researchers pursuing cutting-edge research and ambitious goals. “These visionary Packard Fellows are pushing the boundaries of knowledge, and their bold ideas will become tomorrow’s real-world solutions,” says Nancy Lindborg, president and CEO of the Packard Foundation in a recent press release.

The flexible funding allows researchers to maximize their creativity and ingenuity. Stroud will spend the next five years transforming Lizard Island into the world’s premier evolutionary observatory, merging groundbreaking technology with long-term field research.

On Lizard Island, that means equipping every lizard with an ultra-lightweight sensor “backpack.” Although the sensors weigh just six-hundredths of a gram each — the same as two grains of rice — when combined with innovations in mapping technology, they will help Stroud investigate the role that behavior plays in driving evolution in the wild.

“I’m incredibly honored to be named a 2025 Packard Fellow,” says Stroud. “This support allows me to pursue a question that has fascinated evolutionary biologists for centuries: how does behavior shape evolution? It’s a transformative opportunity, and I’m deeply grateful to the Packard Foundation for believing in the potential of this work.”

Tiny sensors, big questions

Begun in 2015, Stroud’s work on Lizard Island is one of the longest-running evolutionary studies of its kind: for the last 10 years, he has carefully caught and released every lizard on the island, measuring evolution through documenting their body characteristics, habitat use, and survival.

Through his studies, he has captured evolution in action, but monitoring and measuring behavior in evolutionary studies has historically been an extremely difficult and elusive task. The problem? While smaller animals tend to have higher population densities and reproduce more quickly (making them ideal candidates for evolutionary field studies), it has been difficult to find durable and long-lasting sensors small enough for these animals to carry.

“This has been a missing link because behavior is a critical component of evolution,” Stroud says. “Behavior can both expose individuals to — or shield them from — natural selection. For example, an animal with a less favorable trait, like bad eyesight, could change its behavior to avoid situations where it is disadvantaged. 

“These decisions can ultimately determine whether they survive and reproduce in the wild, directly influencing the outcome of natural selection. However, until now, we just haven’t had the technology to measure these types of extremely intricate behaviors across many individuals before.”

Mapping the future

Stroud won’t just know exactly where each lizard is — he’ll also create a detailed three-dimensional map of the entire island using remote sensing technology called LiDAR, updating it each year. “By shooting millions of laser beams, we can create a highly detailed three-dimensional map of Lizard Island, capturing the shape of every branch, rock, and blade of grass on the island,” he explains. “When connected to our lizard backpacks, we’ll know the exact microhabitats and resources available to each lizard as they move through this environment.”

Stroud will also deploy hundreds of microclimate sensors to understand how species are reacting to changes in temperature and climate. The result will be the world’s first comprehensive database: a record of minute lizard movements, the resources each individual uses, daily interactions, and changes in the environment spanning seasons and years. 

“For evolutionary scientists, it has been seemingly impossible to track the moment-by-moment decisions of individual organisms… until now,” he says.

“Today, it’s possible to study what Darwin could only dream of — evolution occurring in real time,” Stroud adds. “Behavior is a critical component of evolution, understanding evolution is critical to understanding life on Earth, and understanding life on Earth is more important than ever.”

Stroud will spend the next five years transforming Lizard Island into the world’s premier evolutionary observatory, merging groundbreaking technology with long-term field research.

Stroud will spend the next five years transforming Lizard Island into the world’s premier evolutionary observatory, merging groundbreaking technology with long-term field research.

James Stroud examines a lizard in the field. (Day’s Edge Productions)

James Stroud examines a lizard in the field. (Day’s Edge Productions)

 
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Written by Selena Langner