We strive to innovate in ways that both advance the imaging science and also impact biological and translational research. We are particularly interested in new imaging physics, bottom-up opto-electronic system design, as well as new principles for light propagation, light-matter interaction and image formation in complex biological materials, especially at the single-molecule level. Toward the application end, we have expertise in a wide range of imaging instrumentation and techniques, such as super-resolution, adaptive optics, light-field, miniaturized, light-sheet, computational microscopy and endoscopy.