Special Delivery Nanoparticle Sidesteps the ‘Middlemen’

James Dahlman, BME researcher and specialist in lipid nanoparticles

James Dahlman's research team has developed a better lipid nanoparticle, capable of programming stem cells inside the body, eliminating the need for chemotherapy and bone marrow extraction.

Middlemen get a bad rap for adding cost and complications to an operation. So, eliminating the go-betweens can reduce expense and simplify a process, increasing efficiency and consumer happiness. 

James Dahlman and his research team have been thinking along those same lines for stem cell treatments. They’ve created a technique that eliminates noisome middlemen and could lead to new, less-invasive treatments for blood disorders and genetic diseases. It sidesteps the discomfort and risks of current treatments, making life easier for patients.

“This would be an alternative to invasive hematopoietic stem cell therapies — we could just give you an IV drip,” said Dahlman, McCamish Early Career Professor in the Wallace H. Coulter Department of Biomedical Engineering. “It simplifies the process and reduces the risks to patients. That’s why this work is important.”

Dahlman and a team of investigators from Georgia Tech, Emory University, and the University of California, Davis, published their approach in the journal Nature Biotechnology.

Minding the Parents

Hematopoietic stem cells (HSCs) are like parent cells. Residing in the bone marrow, they produce all types of cells needed to sustain the blood and immune systems. Their versatility makes HSCs a valuable therapeutic tool in treating genetic blood diseases, such as sickle cell anemia, immune deficiencies, and some cancers. 

HSC therapies usually involve extracting cells from the patient’s bone marrow and re-engineering them in a lab. Meanwhile, the patient endures chemotherapy to help prepare their body to receive the modified HSCs.

“These therapies are effective but also hard on the patients,” Dahlman said. “Patients undergo chemotherapy to wipe out their immune systems so the body will accept the therapeutic cells without a fight. The procedure can be life-threatening. We’re hoping to change that.”

HSCs can also be modified directly inside the body. The procedure uses lipid nanoparticles (LNPs) to carry genetic instructions to the stem cells. The LNPs have targeting ligands attached — molecules designed to find specific target cells. Precisely engineering them adds layers of time, complexity, and cost to the process. They are, like extraction from bone marrow and chemotherapy, another middleman.

The researchers wanted something simpler. They found it in a specific nanoparticle called LNP67.

“Unlike other nanoparticle designs, this one doesn’t require a targeting ligand,” Dahlman said. “It’s chemically simple, which means it’s easier to manufacture and opens the door to eventually scaling production, like mRNA vaccines.”

Overcoming the Liver

The key to LNP67’s success is its ability to dodge the liver, the body’s primary blood filter. Foreign invaders, even helpful invaders delivered through an IV as medicine, can be captured by a healthy liver. 

“The liver absorbs almost everything,” Dahlman said. “But, by reducing what it captures by even as little as 10 percent, we can double delivery to other tissues where the nanoparticles and their payloads are needed.”

The researchers developed 128 unique nanoparticles, narrowing the list down to 105 LNPs that didn’t have targeting ligands. These were ultimately screened and evaluated for their performance in delivering genetic instructions (in the form of mRNA) effectively and safely. 

LNP67 emerged as the best performer thanks to its stealthy design. For example, the surface is designed to repel proteins and other molecules that would mark the LNP for capture by the liver. This feature helped the particles circulate more evenly in the body and reach the HSCs.

“We achieved low-dose delivery without a target ligand, which is exciting,” Dahlman said. “This is something we’ve been working toward for years, and I’m very happy we got there.”

Citation: Hyejin Kim, Ryan Zenhausern, Kara Gentry, Liming Lian, Sebastian G. Huayamares, Afsane Radmand, David Loughrey, Ananda Podilapu, Marine Z. C. Hatit, Huanzhen Ni, Andrea Li, Aram Shajii, Hannah E. Peck, Keyi Han, Xuanwen Hua, Shu Jia, Michele Martinez, Charles Lee, Philip J. Santangelo, Alice Tarantal, James E. Dahlman. Lipid Nanoparticle Study, Nov. 2024, Nature Biotechnology.

Funding: This research was supported by the National Institutes of Health grants UL1TR002378, UH3-TR002855, U42 OD027094, and TL1DK136047; National Science Foundation grant 0923395. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of any funding agency.

Competing Interests: James Dahlman, Marine Z. C. Hatit, and Huanzhen Ni have filed a provisional patent related to this manuscript (US patent application number 63/632,354). 

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Georgia Tech Alum Johney Green Selected as New Lab Director at Savannah River National Lab

Portrait of Johney Green, SEI EAB Member

Johney Green

Johney Green Jr., M.S. ME 1993, Ph.D. ME 2000, has been chosen to serve as the new laboratory director for Savannah River National Laboratory (SRNL). A proud Yellow Jacket, Green received both his master’s and doctoral degrees in mechanical engineering from Georgia Tech and currently serves on the Strategic Energy Institute’s (SEI) External Advisory Board. He also served on the board of the George W. Woodruff School of Mechanical Engineering from 2017 to 2022.

“SRNL has truly found an exceptional leader in Johney. His vision and dedication are inspiring, and I am genuinely excited to see the remarkable contributions he will make in advancing SRNL,” said Christine Conwell, SEI interim executive director. “We look forward to his continued partnership with SEI and the positive impact he will bring to the energy community in 2025 and beyond.”

The Battelle Savannah River Alliance (SRNL’s parent organization) selected Green for this role, describing him as “a dynamic leader who brings deep, wide-ranging scientific expertise to this new position.” 

With an annual operating budget of about $400 million, SRNL is a multiprogram national lab leading research and development for the Department of Energy’s (DOE) Offices of Environmental Management and Legacy Management and the National Nuclear Security Administration’s weapons and nonproliferation programs. 

Green currently serves as associate laboratory director for mechanical and thermal engineering sciences at the National Renewable Energy Laboratory (NREL). In this position, he oversees a diverse portfolio of research programs including transportation, buildings, wind, water, geothermal, advanced manufacturing, concentrating solar power, and Arctic research. His leadership impacts a workforce of about 750 and involves managing a budget of more than $300 million.

At NREL, Green transformed the lab’s wind site into the innovative Flatirons Campus and transitioned the campus from a single-program wind research site to a multiprogram research campus that serves as the foundational experimental platform for the DOE’s Advanced Research on Integrated Energy Systems (ARIES) initiative.

"We are immensely proud to call Johney a Woodruff School alumnus. His achievements and service to Tech through advisory board engagement inspires us, and we are excited to see him step into this prestigious role at SRNL. We look forward to deepening our collaboration with him as he continues to make a powerful impact,” said Devesh Ranjan, Eugene C. Gwaltney, Jr. School Chair and professor in the Woodruff School.

Prior to his role at NREL, Green held several key leadership roles at Oak Ridge National Laboratory (ORNL). As director of the Energy and Transportation Science Division and group leader for fuels, engines, and emissions research, he managed a broad science and technology portfolio and user facilities that made significant science and engineering advances in building technologies; sustainable industrial and manufacturing processes; fuels, engines, emissions, and transportation analysis; and vehicle systems integration. While Green was the division director, ORNL developed the Additive Manufacturing Integrated Energy (AMIE) demonstration project, a model of innovative vehicle-to-grid integration technologies and next-generation manufacturing processes.

Early in his career, Green conducted combustion research to stabilize gasoline engine operation under extreme conditions. During the course of that research, he joined a team working with Ford Motor Co., seeking ways to simultaneously extend exhaust gas recirculation limits in diesel engines and reduce nitrogen oxide and particulate matter emissions. He continued this collaboration as a visiting scientist at Ford's Scientific Research Laboratory, conducting modeling and experimental research for advanced diesel engines designed for light-duty vehicles. On assignment to the DOE’s Vehicle Technologies Office, Green also served as technical coordinator for the 21st Century Truck Partnership. He also contributed to a dozen of ORNL's 150-plus top scientific discoveries.

Green was the recipient of a National GEM Consortium Master’s Fellowhip sponsored by Georgia Tech and ORNL, and he served as the National GEM Consortium chairperson from 2022-2024. He is a Fellow of the American Association for the Advancement of Science and an SAE International Fellow. He has received several awards during his career and holds two U.S. patents in combustion science. 

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Priya Devarajan || SEI Communications Program Manager

New Database Revolutionizes Protein-Lipid Research

Lipids can be powerful tools to help deliver drugs and treatments through their interactions with proteins. (Adobe Stock)

Lipids can be powerful tools to help deliver drugs and treatments through their interactions with proteins. (Adobe Stock)

From combating cancer and infections to storing energy, lipid-protein interactions are critical to biological processes in cells. But the mechanisms that drive these interactions have historically been difficult to map and understand.

A study led by Georgia Tech is showcasing a new resource to help researchers understand the structure and function of these interactions — called assemblies — at both molecular and functional levels. The work is published in the Nature-family journal Communications Chemistry.

Called BioDolphin — short for Biological Database of Lipid-Protein Highly Inclusive Interactions — the resource is the first comprehensive, annotated database of protein-lipid interactions. Integrated into a user-friendly web server, BioDolphin is freely accessible to all. Users can easily view and download interaction data and systematically analyze lipid-protein assemblies.

“Understanding lipid-protein interactions is crucial in advancing our understanding of human health and disease treatment,” says the study’s corresponding author, Andrew McShan. “BioDolphin is the first resource to collect this type of information for all kinds of proteins, not just those found in membranes. And because it is publicly available, this information is now at the tips of researchers’ fingertips.”

BioDolphin as a comprehensive database of lipid–protein binding interactions” is led by McShan, an assistant professor in the School of Chemistry and Biochemistry at Georgia Tech, alongside first author Li-Yen (Zoey) YangBioinformatics Ph.D. student; School of Computational Science and Engineering Assistant Professor Yunan Luo; and Kaike Ping, a Ph.D. student at Virginia Tech.

Diving into accessible data

A curated database with richly annotated information, BioDolphin contains over 127,000 lipid-protein binding interactions. And while most databases of lipid-protein assemblies have focused solely on a specific type of protein — membrane proteins — BioDolphin expands beyond that.

“BioDolphin enables us to globally define the structural features of lipid-protein assemblies across the eight different classes of lipid compounds to understand their cellular function and roles in disease,” says McShan, adding that the database also provides information on paired lipid-protein annotation, experimental binding affinities, intermolecular interactions, and atomic structures across a wide range of lipid-protein interactions — all available to anyone with an internet connection.

A molecular blueprint for research — and teaching

“In the past, this research has been limited because lipids are notoriously difficult to study in the lab,” McShan says. "BioDolphin changes the paradigm. It is the first time that anyone has collected, annotated, and analyzed the known structural universe of lipid-protein interactions across all organisms.”

It’s a rapidly developing field. McShan was recently awarded a prestigious Curci grant for cutting-edge cancer research into lipid-based universal immunotherapies and vaccines.

Beyond research applications, the team hopes that BioDolphin will be a resource for biochemistry students. 

“The database can serve as a tool for teachers and students studying these protein-lipid interactions, which is often an underdeveloped topic in biology and biochemistry courses,” McShan says. “I hope that BioDolphin is a valuable resource for the researchers of today — and that it can also be a building block for the researchers of tomorrow.”

Funding: Shurl and Kay Curci Foundation, NSF Advanced Cyberinfrastructure Coordination Ecosystem: Services & Support (ACCESS) program, NIH National Institute of General Medical Sciences (NIGMS), Partnership for an Advanced Computing Environment (PACE) at the Georgia Institute of Technology, and Taiwan Ministry of Education Government Scholarship to Study Abroad program.

DOI: https://doi.org/10.1038/s42004-024-01384-z 

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Written by Selena Langner

Contact: Jess Hunt-Ralston

Solar Geoengineering Could Save 400,000 Lives a Year, Georgia Tech Study Says

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Assistant Professor Anthony Harding

When it comes to finding solutions to climate change, there’s no shortage of technologies vying for attention, from renewable energy to electric vehicles to nuclear energy. One such contender, solar geoengineering, is favored by proponents who say it could quickly cool the planet and give the world time to fully implement efforts to limit emissions and remove carbon from the atmosphere.  

But that promise comes with risks, which include potentially poorer air quality or depleted atmospheric ozone – both of which can cause serious health issues of their own. 

A new Georgia Tech School of Public Policy-led study published in the Proceedings of the National Academy of Sciences (PNAS) suggests that while those risks deserve further consideration, solar geoengineering could save as many as 400,000 lives a year through a reduction in temperature-related deaths attributable to climate change.  

“An important question is how the reduction in climate risks from solar geoengineering compares to the additional risks its use entails,” said lead author Anthony Harding of the School of Public Policy. “This study offers a first step in quantifying the risks and benefits of solar geoengineering and shows that, for the risks we considered, the potential to save lives outweighs the direct risks,"  

Harding co-authored the PNAS article with Gabriel Vecchi and Wenchang Yang of Princeton University and David Keith from the University of Chicago. 

The researchers studied a climate change mitigation strategy called stratospheric aerosol injection (SAI), a type of solar geoengineering that involves spraying tiny reflective particles into the upper atmosphere. Those particles would then redirect some sunlight back to space and help cool Earth. 

The authors used computer models and historical data on how temperature affects death rates to see how much solar geoengineering might affect death rates, assuming a 2.5-degree Celsius increase in average temperature from pre-industrial levels and similar approaches to climate change as seen in the world currently. 

They found that cooling global temperatures by 1 degree Celsius with solar geoengineering would save 400,000 lives each year, outweighing deaths caused by solar geoengineering’s direct health risks from air pollution and ozone depletion by a factor of 13. This means that the number of lives saved due to solar geoengineering-caused cooling would be 13 times the number of lives potentially lost from solar geoengineering’s known risks. 

Many of those deaths would be avoided in hotter, poorer regions, the study notes. Cooler, wealthier regions could actually face increased cold-related deaths. 

Solar geoengineering has generated millions of dollars in funding and a recommendation by the National Academies of Science that the federal government should provide millions more toward research and the development of a risk-risk analysis similar to what Harding’s team produced. But the tech has also drawn concern, including from the Union of Concerned Scientists. That group says there’s too much environmental, ethical, and geopolitical risk to proceed without much more research. 

The authors caution that their study is an important starting point in better understanding solar geoengineering's promise and peril but is far from a comprehensive evaluation of the technology’s risks and benefits. 

They say their models are based on idealized assumptions about aerosol distribution, population and income growth, and other factors. They also can’t capture all of the real-world complexities that solar geoengineering would entail. They note their study also does not address all of the potential risks of solar geoengineering, such as possible impacts on ecosystems, global politics, or the possibility governments will rely on the technology to delay politically difficult emissions cuts. 

Still, the researchers say, the study suggests that for many regions, solar geoengineering could well be more effective at saving lives than emissions reductions alone and is worth keeping in the mix as the world searches for the optimal ways to cool our warming planet. 

“There’s no perfect resolution to the climate crisis,” said Harding. “Solar geoengineering entails risks, but it could also alleviate real suffering, so we need to better understand how the risks compare to the benefits to inform any potential future decisions around the technology.” 

The paper, “Impact of Solar Geoengineering on Temperature-Attributable Mortality,” was published in the Proceedings of the National Academy of Sciences on Dec. 17. It is available at https://doi.org/10.1073/pnas.2401801121. 

 

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Michael Pearson
Ivan Allen College of Liberal Arts

Georgia Tech’s Research Next Initiative Concludes With Groundbreaking Achievements

Two Georgia Tech researchers working in a lab.

The next is now at Georgia Tech.

The Institute’s Research Next initiative has officially concluded with a legacy of successes that help redefine the future of interdisciplinary research. It launched nearly five years ago as a bold strategy to enhance Georgia Tech’s research capabilities and address some of the world’s most pressing challenges. 

Research Next was composed of three phases. At its outset, the Commission on Research Next tapped the knowledge and expertise of Georgia Tech faculty, staff, and students to broadly analyze the future research landscape for Georgia Tech and for other research-intensive universities. 

Then, a second team of faculty, staff, and students worked on Phase 2 of the effort. They created goals aligned with the Institute Strategic Plan to help Georgia Tech respond to the challenges identified in Phase 1. Phase 3 assembled implementation teams to create strategies for achieving the goals laid out in Phase 2. 

Tim Lieuwen, Georgia Tech’s interim executive vice president for Research and Research Next co-chair, said he is excited about the initiative’s achievements and its “transformative outcomes.”

“Thanks to the valuable input from our Georgia Tech community, the Research Next team created a framework for the role of research universities in solving societal problems. That led to several significant Georgia Tech initiatives, including HBCU engagement, launching center-scale efforts, research leadership development, and research faculty support. I am particularly proud these initiatives are centered around supporting and developing the people who make our research enterprise thrive,” he said.

Key Outcomes

  • Scaling Research Operations: Identified pain points in invoicing and procurement, onboarded a research center startup manager, and advanced project management workflows.
  • HBCU/MSI Partnerships: Hired a program manager, hosted the 2023 Research Collaboration Forum with 170 attendees, and launched CollabNexta software tool to help foster partnerships between Georgia Tech and HBCU faculty members who have similar interests. Our HBCU program was highlighted by the White House and President of the United States.
  • Research Faculty Support: Established an associate vice president for research faculty, improved onboarding, and launched several mentoring programs.
  • Community Building: Fostered connectedness with events like Research Administrators’ Day and launched Spotlight Awards for staff, faculty, and postdoctoral researchers.
  • Improved Administration: Updated 40-plus policies, expanded training, and began developing a chatbot to streamline award lifecycle processes.
  • Leadership Development: Created the Research Leadership Academy, launching in Spring 2025, to prepare leaders for large-scale research initiatives.

“Research Next has reshaped our interdisciplinary research framework,” said Research Next co-chair Mark Whorton. “By addressing operational excellence and enhancing strategic collaborations, we've cultivated a more cohesive and dynamic research setting that drives innovation and discovery."

One of the enduring legacies of Research Next is an annual strategic analysis to shape new research and enhance existing projects. It’s meant to foster collaboration, improve communication, and inform hiring priorities. The strategic analysis is an integral component of Georgia Tech President Ángel Cabrera’s Big Bets.

Chaouki Abdallah, former Georgia Tech executive vice president for Research, launched Research Next to equip Georgia Tech for future challenges through “innovation, expertise, creativity, and a commitment to improving lives.”

In celebrating its conclusion, Abdallah said, "Research Next has demonstrated that when we come together with a shared vision and plans, we achieve remarkable things. In addition to advancing the Georgia Tech’s research capabilities, the outcomes of this initiative reinforce the Institute’s commitment to serving society as a whole. I am excited to see how Georgia Tech will build on this foundation to drive meaningful impact regionally, nationally, and globally."

Georgia Tech Continues to Rise in Research Expenditure National Rankings

Ulrika Egertsdotter, a principal research scientist in the Renewable Bioproducts Institute, studies plant growth and development in vitro, with forestry, agricultural, and horticultural applications.

The National Science Foundation has released the results of its annual Higher Education Research and Development Survey (HERD), and Georgia Tech has again moved up in the rankings.  

The survey of U.S. university research and development expenditures places Georgia Tech as No. 16, up from No. 17 last year, and remaining No. 1 among universities without a medical school. The Institute ranks No. 3 for federally funded research, up from No. 5, and is No. 7 for all externally funded research, up from No. 9. 

“Georgia Tech's continued ascension in research rankings is a testament to the exceptional dedication and collaboration of our faculty, staff, and research sponsors,” said Tim Lieuwen, interim executive vice president for Research. “This trajectory, particularly our rise in federally and externally funded research, amplifies the confidence our partners have in Georgia Tech tackle society’s biggest challenges.”  

The annual survey compiles R&D expenditure data from U.S. colleges and universities with more than $150,000 in research expenditures during a fiscal year. For fiscal year 2023 (July 1, 2022 – June 30, 2023), that included 914 institutions.  Overall, U.S. higher-education R&D spending rose by 11.2%, exceeding $108 billion in fiscal year 2023. This is the largest increase since 2003. 

Georgia Tech’s R&D spending of $1.45 billion in fiscal year 2023 reflects an impressive 17.9% increase — $219 million more — from the previous year for the entire research enterprise, which includes the Georgia Tech Research Institute (GTRI). GTRI remains the largest contributor to Georgia Tech’s growth and continues to play a major role in the Institute’s research enterprise and in national defense research. 

Additionally, Georgia Tech’s R&D expenditures contributed a monumental $1.45 billion to the state of Georgia’s economy, along with continued growth in commercialization efforts that bring technologies out of the lab and into to the world. 

Lieuwen said, “I am proud of these standings and even more excited about the possibilities ahead as we continue to drive innovation that benefits our state, the nation, and the world.” 

About Georgia Tech’s Office of the Executive Vice President for Research 

The Office of the Executive Vice President for Research (EVPR) directs Georgia Tech’s $1.37 billion (FY 2024) portfolio of research, development, and sponsored activities. This includes leadership of the Georgia Tech Research Institute (GTRI), the Enterprise Innovation Institute, nine interdisciplinary research institutes (IRIs) plus research centers, and related research administrative support units: commercialization, corporate engagement, research development and operations, and research administration. Georgia Tech routinely ranks among the top U.S. universities in volume of research conducted.  

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Shelley Wunder-Smith | shelley.wunder-smith@research.gatech.edu
Director of Research Communications

When Two Lizards Meet for the First Time, Scientists Witness Evolution in Action

Two Cuban brown anoles, Anolis sagrei (Credit: Day's Edge Productions)

Two Cuban brown anoles, Anolis sagrei (Credit: Day's Edge Productions)

In South Florida, two Caribbean lizard species met for the first time. What followed provided some of the clearest evidence to date of evolution in action. 

Lead author James Stroudan assistant professor in the School of Biological Sciences, was studying Cuban brown anoles (Anolis sagrei) in South Florida when the Puerto Rican crested anole (Anolis cristatellus), suddenly appeared in the region.

Published in Nature Communications, the study documents what happens as the two Anolis lizards adapted in response to the new competitor, while helping to resolve a longstanding challenge in evolutionary biology — directly observing the role of natural selection in character displacement: how similar animals adapt in response to competition.

"Most of what we know about how animals change in response to this process comes from studying patterns that evolved long ago,” Stroud says. “This was a rare opportunity where we could watch evolution as it happened."

Competition from coexistence 

While these two small, brown lizards diverged evolutionarily between 40-60 million years ago and evolved on completely separate Caribbean islands, the two species are nearly identical, and fill similar ecological niches.

So, when the Puerto Rican crested anole suddenly appeared in Cuban brown anole habitat at Fairchild Tropical Botanic Garden in 2018, the two were competing for similar habitats and food sources.

“When two similar species compete for the same resources, like food and territory, they often evolve differences that allow them to coexist,” Stroud says. But, while scientists have found many examples of similar species developing different traits to ease this overlap, “scientists have rarely been able to observe this process as it unfolds in nature.”

Stroud’s team had already been studying Cuban brown anoles at the Fairchild Tropical Botanic Gardens in Miami, Florida, two years prior to when the crested anoles invaded. The team was able to quickly pivot to observe how the invasion changed both species, analyzing the lizards’ changing diets, measuring if the lizards were moving through foliage or on the forest floor, and recording the different species’ locations relative to each other. For over a thousand lizards, they also measured perch height — the distance from the ground that the lizard is perching — a primary marker of how Anolis lizards divvy up habitat.

“We not only observed how these lizards changed their habitat use and behavior when they encountered each other,” says Stroud, “but we also documented the natural selection pressures driving their physical evolution in real-time."

Human-made habitats and natural experiments

The research team found that when these lizard species occur together, they divide up their habitat in predictable ways — the Cuban brown anole shifted to spend more time on the ground, and evolved longer legs to run faster in this habitat, while the slightly larger Cuban crested anole lived in vegetation above the ground. 

"We found that brown anoles with longer legs had higher survival after crested anoles showed up," says Stroud. "This matches perfectly with the physical differences we see in populations where these species have been living together for many generations."

Stroud adds that while the research provides some of the strongest observations of evolution in action to date, it also demonstrates how human activities can create natural experiments that help us understand fundamental evolutionary processes — both species of Anolis lizard in the study were originally non-native to South Florida.

“As species increasingly come into contact due to human-mediated introductions and climate change, these studies may be important for predicting how communities will respond,” he says. "By studying these non-native lizards who are meeting each other for the first time in their existence, we had a unique opportunity to see the actual process unfold and connect it to the patterns we observe in nature."

A Cuban brown anole (Anolis sagrei) in Miami (Credit: Day's Edge Productions)

A Cuban brown anole (Anolis sagrei) in Miami (Credit: Day's Edge Productions)

A Puerto Rican crested anole, Anolis cristatellus (Credit: Days Edge Productions)

A Puerto Rican crested anole, Anolis cristatellus (Credit: Day's Edge Productions)

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Written by Selena Langner

Contact: Jess Hunt-Ralston

$100M Investment Will Propel Absolics Inc., Georgia Tech’s Advanced Packaging Research

Man holding computer chip

As part of the CHIPS National Advanced Packaging Manufacturing Program (NAPMP), three advanced packaging research projects will receive investments of up to $100 million each. This work will accelerate the development of cutting-edge substrate and materials technologies essential to the semiconductor industry.  

NAPMP was developed to support a robust U.S. ecosystem for advanced packaging, which is key to every electronic system. NAPMP will enable leading-edge research and development, domestic manufacturing facilities, and robust training and workforce development programs in advanced packaging.  

In partnership with Georgia Tech and the 3D Packaging Research Center (PRC), Absolics will receive $100 million to develop revolutionary glass core substrate panel manufacturing. 

“This landmark investment in Absolics is also a transformational investment in Georgia Tech,” said Tim Lieuwen, interim executive vice president for Research. “It will redefine the possibilities of our longstanding partnership by expanding Georgia Tech’s expertise in electronic packaging, which is vital to the semiconductor supply chain. This federal funding uniquely positions us to merge cutting-edge research with industry, drive economic development in Georgia, and create a workforce ready to tackle tomorrow’s manufacturing demands.” 

Georgia Tech has a long history of pioneering packaging research. Through a previous collaboration with the PRC, Absolics has already invested in the state of Georgia by building a glass core substrate panel manufacturing facility in Covington.  

Georgia Tech’s Institute for Matter and Systems (IMS), home to the PRC, houses specialized core facilities with the capabilities for semiconductor advanced packaging research and development. 

“Awards like this reinforce the importance of collaborative research between research disciplines and the private and public sector. Without the research and administrative support provided by IMS and the Georgia Tech Office of Research Development, projects like this would not be coming to Georgia Tech.” said Eric Vogel, IMS executive director. 

 Georgia Tech is a leader in advanced packaging research and has been working on glass substrate packaging research and development for years. Through this new Substrate and Materials Advanced Research and Technology (SMART) Packaging Program, Absolics aims to build a glass-core packaging ecosystem. In collaboration with Absolics, Georgia Tech will receive money for research and development for a glass-core substrate research center.  

“We are delighted to partner with Absolics and the broader team on this new NAPMP program focused on glass-core packaging,” said Muhannad Bakir, Dan Fielder Professor in the School of Electrical and Computer Engineering and PRC director. “Georgia Tech’s role will span program leadership, research and development of novel glass-core packages, technology transition, and workforce development.” Bakir will serve as the associate director of SMART Packaging Program, overseeing research and workforce development activities while also leading several research tasks.  

 "This project will advance large-area glass panel processing with innovative contributions to materials and processing, modeling and simulation, metrology and characterization, and testing and reliability. We are pleased to partner with Absolics in advancing these important technology areas," said Regents' Professor Suresh K. Sitaraman of the George W. Woodruff School of Mechanical Engineering and the PRC. In addition to technical contributions, Sitaraman will direct the new SMART Packaging Program steering committee.  

 “The NAPMP Materials and Substrates R&D award for glass substrates marks the culmination of extensive efforts spearheaded by Georgia Tech’s Packaging Research Center,” noted George White, senior director of strategic partnerships and the theme leader for education and workforce development in the SMART Packaging Program. “This recognition highlights the state of Georgia’s leadership in advanced substrate technology and paves the way for developing the next generation of talent in glass-based packaging.”  

 The program will support education and workforce development efforts by bringing training, internships, and certificate opportunities to technical colleges, the HBCU CHIPS Network, and veterans' programs. 

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Amelia Neumeister | Research Communications Program Manager

Georgia AIM Week: Making Manufacturing Cool

Georgia AIM representatives talk with students on Georgia Tech's campus during the launch event for their new mobile labs.

Georgia AIM representatives talk with students on Georgia Tech's campus during the launch event for their new mobile labs.

Gold and white pompoms fluttered while Buzz, the official mascot of the Georgia Institute of Technology, danced to marching band music. But the celebration wasn’t before a football or basketball game — instead, the cheers marked the official launch of Georgia AIM Week, a series of events and a new mobile lab designed to bring technology to all parts of Georgia

Organized by Georgia Artificial Intelligence in Manufacturing (Georgia AIM), Georgia AIM Week kicked off September 30 with a celebration on the Georgia Institute of Technology campus and culminated with another celebration on Friday at the University of Georgia in Athens and aligned with National Manufacturing Day.

In between, the Georgia AIM Mobile Studio made stops at schools and community organizations to showcase a range of technology rooted in AI and smart technology.

“Georgia AIM Week was a statewide opportunity for us to celebrate Manufacturing Day and to launch our Georgia AIM Mobile Studio,” said Donna Ennis, associate vice president, community-based engagement, for Georgia Tech’s Enterprise Innovation Institute and Georgia AIM co-director. “Georgia AIM projects planned events in cities around the state, starting here in Atlanta. Then we headed to Warner Robins, Southwest Georgia, and Athens. We’re excited about the opportunity to bring this technology to our communities and increase access and ideas related to smart technology.”

Georgia AIM is a collaboration across the state to provide the tools and knowledge to empower all communities, particularly those that have been underserved and overlooked in manufacturing. This includes rural communities, women, people of color, and veterans. Georgia AIM projects are located across the state and work within communities to create a diverse AI manufacturing workforce. The federally funded program is a collaborative project administered through Georgia Tech’s Enterprise Innovation Institute and the Georgia Tech Manufacturing Institute.

A cornerstone of Georgia AIM Week was the debut of the Georgia AIM Mobile Studio, a 53-foot custom trailer outfitted with technology that can be used in manufacturing — but also by anyone with an interest in learning about AI and smart technology. Visitors to the mobile studio can experience virtual reality, 3-D printing, drones, robots, sensors, computer vision, and circuits essential to running this new tech.

There’s even a dog — albeit a robotic one — named Nova.

The studio was designed to introduce students to the possibilities of careers in manufacturing and show small businesses some of the cost-effective ways they can incorporate 21st century technology into their manufacturing operations.

“We were awarded about $7.5 million to build this wonderful studio here,” said Kenya Asbill, who works at the Russell Innovation Center for Entrepreneurs (RICE) as the Economic Development Administration project manager for Georgia AIM. “We will be traveling around the state of Georgia to introduce artificial intelligence in manufacturing to our targeted communities, including underserved rural and urban residents.”

Some technology on the Georgia AIM Mobile Studio was designed in consultation with project partners Kitt Labs and Technologists of Color. An additional suite of “technology vignettes” were developed by students at the University of Georgia College of Engineering. RICE and UGA served as project leads for the mobile studio development, and RICE will oversee its deployment across the state in the coming months.

To request a mobile studio visit, please visit the Georgia AIM website.

During Monday’s kickoff, the Georgia Tech cheerleaders and Buzz fired up the crowd before an event that featured remarks by Acting Assistant Secretary of the U.S. EDA Christina Killingsworth; Jay Bailey, president and CEO of RICE; Beshoy Morkos, associate professor of mechanical engineering at the University of Georgia; Aaron Stebner, co-director of Georgia AIM; David Bridges, vice president of Georgia Tech’s Enterprise Innovation Institute; and lightning presentations by Georgia AIM project leads from around the state.

Following the presentations, mobile studio tours were led by Jon Exume, president and executive director, and Mark Lawson, director of technology, for Technologists of Color. The organization works to create a cohesive and thriving community of African Americans in tech.

“I’m particularly excited to witness the launch of the Georgia AIM Mobile Studio. It really will help demystify AI and bring its promise to underserved rural areas across the state,” Killingsworth said. “AI is the defining technology of our generation. It’s transforming the global economy, and it will continue to have tremendous impact on the global workforce. And while AI has the potential to democratize access to information, enhance efficiency, and allow humans to focus on the more complex, creative, and meaningful aspects of work, it also has the power to exacerbate economic disparity. As such, we must work together to embrace the promise of AI while mitigating its risks.”

Other events during Georgia AIM week included the Middle Georgia Innovation Corridor Manufacturing Expo in Warner Robins, West Georgia Manufacturing Day – Student Career Expo in LaGrange, and a visit to Colquitt County High School in Moultrie. The week wrapped on Friday, Oct. 4, at the University of Georgia in Athens with a National Manufacturing Day celebration.

“We’re focused on growing our manufacturing economy,” Ennis said. “We’re also focused on the development and deployment of innovation and talent in the manufacturing industry as it relates to AI and other technologies. Manufacturing is cool. It is a changing industry. We want our students and younger people to understand that this is a career.”

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