Working Smarter: Improving Personalized Stem Cell Treatments for Kids

stem

Stem cell therapies are improving recovery and survival rates for pediatric cancer patients. But the treatments can be risky. They can weaken the immune system, making children highly vulnerable to infections. And there are other potential long-term complications, including damage to tissues and organs.

A team of researchers at Georgia Tech has addressed this challenge, creating a new way to predict how these cutting-edge treatments might work in a particular patient. And it could revolutionize treatments for kids with complex immune system challenges.

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By Jerry Grillo

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INNS Executive Director Search Vision Talk: Candidate 3

Three finalists have been chosen for the role of Executive Director of the Institute for Neuroscience, Neurotechnology, and Society (INNS). Each finalist will meet with Georgia Tech faculty, staff, and IRI leadership and give a seminar on their vision for the INNS.

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INNS Executive Director Search Vision Talk: Candidate 2

Three finalists have been chosen for the role of Executive Director of the Institute for Neuroscience, Neurotechnology, and Society (INNS). Each finalist will meet with Georgia Tech faculty, staff, and IRI leadership and give a seminar on their vision for the INNS.

Finalist 2: Chris Rozell
Date: June 3rd, 2025
Time: 11a.m. - Noon 
Location: Callaway Manufacturing Research Building (GT Manufacturing Institute)
813 Ferst Drive NW, Atlanta, GA 30332,  seminar room 114

INNS Executive Director Search Vision Talk: Candidate 1

Three finalists have been chosen for the role of Executive Director of the Institute for Neuroscience, Neurotechnology, and Society (INNS). Each finalist will meet with Georgia Tech faculty, staff, and IRI leadership and give a seminar on their vision for the INNS.

Finalist 1: Lewis Wheaton
Date: May 28th, 2025
Time: 11a.m. - Noon 
Location: Callaway Manufacturing Research Building (GT Manufacturing Institute)
813 Ferst Drive NW, Atlanta, GA 30332,  seminar room 114

Painting a Target on Cancer to Make Therapy More Effective

Lena Gamboa and Gabe Kwong look at colorized cells on a computer monitor while Ali Zamat loads samples into a cell counting device. (Photo: Candler Hobbs)

The combination approach that Lena Gamboa, seated, Gabe Kwong, foreground, and Ali Zamat developed tags the tumors with a synthetic "flag" then uses specially engineered cells from the patient's own immune system to attack the cancer. They found their approach worked against hard-to-treat breast, brain, and colon cancers. it also turned the cancer into an immune system training ground, allowing the body to recognize and fight any tumors that regrow. (Photo: Candler Hobbs)

Biomedical engineers at Georgia Tech created a treatment that could one day unlock a universal strategy for treating some of the hardest-to-treat cancers — like those in the brain, breast, and colon — by teaching the immune system to see what it usually misses.

Their experimental approach worked against those kinds of cancers in lab tests and didn’t damage healthy tissues. Importantly, it also stopped cancer from returning.

While the therapy is still in early stages of development, it builds on well established, safe technologies, giving the treatment a clearer, quicker path to clinical trials and patient care.

Reported in May in the journal Nature Cancer, their technique is a one-two punch that flags tumor cells so they can be recognized and then eliminated by specially enhanced T cells from the patient’s own immune system.

Get all the details on the College of Engineering website.

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Joshua Stewart
College of Engineering

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