Electing to have invasive brain surgery isn’t something most people have done. Ian Burkhart isn’t most people.

“When I finished rehabilitation, my doctors and therapist and, most importantly, the insurance company said, ‘For someone with your condition, we feel like you've made all the improvement that you will, have a nice life,’” said Burkhart, who was left with limited feeling and mobility below the neck after a 2010 diving accident injured his spinal cord. “That didn't sit well with me.” 

Hoping even a fraction of hand mobility would increase his independence, Burkhart turned to a clinical research trial on a brain-computer interface (BCI) designed to detect movement signals in the brain and send them to a computer to stimulate the arm muscles, bypassing the spinal cord in the hopes of restoring movement.

“I had had four and a half years of never thinking my hand was going to move again,” he recalled. When testing to see if he qualified for the study, researchers stimulated his hand muscles. “I saw my hand move, and that was all I needed to know — I was ready to risk it all for something that may or may not work.” 

Burkhart’s story is one of many that reveal the deeply personal side of neurotechnology research. Centering lived experiences like his is central to the mission of the Institute for Neuroscience, Neurotechnology, and Society (INNS), a new Interdisciplinary Research Institute launching this July at Georgia Tech.

“If we want to build neurotechnology that truly serves people, their voices should be part of the scientific process from the very beginning,” said Chris Rozell, a professor in the School of Electrical and Computer Engineering and one of the many researchers at Georgia Tech working to understand and advance BCIs. “Hearing from individuals who live with these devices helps guide more ethical, inclusive, and effective research. The entire field benefits from inclusive conversations like these.” 

Life With a Brain Implant

Burkhart and three others recently shared their stories live on the Ferst Center stage at “Wired Lives: Personal Stories of Brain-Computer Interfaces, an event organized by Georgia Tech’s Neuro Next Initiative. Their stories gave over 200 attendees a rare, honest glimpse into the realities of neurological conditions and the path to brain-computer interface research.

“I was at a crossroads in my life at 47 years old,” said Brandan Mehaffie, who told his story of living with early-onset Parkinson’s disease. “I was trying to figure out, do I continue with the status quo and watch my career dwindle into nothing? Watch my life with my family, my kids, not being able to go on hikes or family vacations?” 

Mehaffie eventually qualified for deep brain stimulation (DBS) treatment, a procedure where a pacemaker-like device is implanted into the brain to provide electrical stimulation. “It changed my life for the better in ways that I can't even tell you.”

When former U.S. Air Force Sgt. Jennifer Walden’s doctor told her about a clinical trial testing DBS as an epilepsy treatment, she jumped at the chance. “The 48 hours after those seizures are 48 hours where you don't want to live anymore.” Walden explained that her response to medication had dwindled after years of traditional treatment, increasing the frequency and severity of her seizures. “I feared suicide. It's something I didn't want to do, but if something happened in those 48 hours to end my life, I didn't care,” she said.

“I am now probably 99% seizure-free,” she beamed as she recalled her response to DBS on stage. “I don't know how I got so lucky in life, but I don't take it for granted.”

Common themes in their stories were resilience, hope, and a deep desire to give back.

“When I joined the study, it had no physical benefit to me, but that's not why I joined it,” said Scott Imbrie, who experienced a major spinal cord injury and participates in a clinical BCI study at the University of Chicago. “I decided to have invasive brain surgery and have electrodes implanted on my brain to help other people.”

A New Approach to Interdisciplinary Research

Timed alongside the InterfaceNeuro conference at Georgia Tech, the gathering offered a rare opportunity for scientists, engineers, and clinicians to engage directly with the lived experiences of individuals using brain-computer interfaces — a perspective often missing from traditional research settings.

“It makes you think about how we ethically conduct research and how we recruit and interface with patients,” said Eric Cole, a postdoctoral researcher at Emory University, who was reminded that many patients participating in BCI research have been on a long, difficult journey before interacting with researchers. “We should remember to take their experiences seriously and respect them. They're giving up something for research — that part we should always remember.”

“Wired Lives” was one in a series of events highlighting the lived experience of individuals with neurological conditions organized by the Neuro Next Initiative, which has served as the precursor to INNS.

“A core mission of INNS is to consider how neuroscience and neurotechnology impact people’s lives,” said Jennifer Singh, associate professor in the School of History and Sociology, a member of NNI’s executive committee, and a co-organizer of the event. “Their stories matter when it comes to the types of science and technology we pursue and how they benefit the human condition. Many scientists and engineers may never encounter people living with neurological conditions outside of events like this. That will be a priority for INNS — to bring the expertise of lived experiences to the research process.”

Ian Burkhart’s lived experience reminded the audience that not every clinical trial has a happy ending. His BCI was ultimately removed after seven years as research funding ran short, taking his newly improved hand mobility with it. Despite this, Burkhart remained positive.

“I'm so glad I was able to take that risk and have that voluntary brain surgery and participate in this type of research because it's defined my life.” Burkhart went on to found the BCI Pioneers Coalition and his own nonprofit because of his research participation. “It gave me a lot of hope for the future, and a lot of hope that these types of devices are going to be able to help people and improve their quality of life.”

This event was produced in partnership with The Story Collider and made possible through support from Blackrock Neurotech and Medtronic.

Georgia Tech professors Michelle LaPlaca and W. Hong Yeo have been selected as recipients of Peterson Professorships with the Children’s Healthcare of Atlanta Pediatric Technology Center (PTC) at Georgia Tech. The professorships, supported by the G.P. “Bud” Peterson and Valerie H. Peterson Faculty Endowment Fund, are meant to further energize the Georgia Tech and Children’s partnership by engaging and empowering researchers involved in pediatrics.

In a joint statement, PTC co-directors Wilbur Lam and Stanislav Emelianov said, “The appointment of Dr. LaPlaca and Dr. Yeo as Peterson Professors exemplifies the vision of Bud and Valerie Peterson — advancing innovation and collaboration through the Pediatric Technology Center to bring breakthrough ideas from the lab to the bedside, improving the lives of children and transforming healthcare.”

LaPlaca is a professor and associate chair for Faculty Development in the Department of Biomedical Engineering, a joint department between Georgia Tech and Emory University. Her research is focused on traumatic brain injury and concussion, concentrating on sources of heterogeneity and clinical translation. Specifically, she is working on biomarker discovery, the role of the glymphatic system, and novel virtual reality neurological assessments.    

“I am thrilled to be chosen as one of the Peterson Professors and appreciate Bud and Valerie Peterson’s dedication to pediatric research,” she said. “The professorship will allow me to broaden research in pediatric concussion assessment and college student concussion awareness, as well as to identify biomarkers in experimental models of brain injury.”

In addition to the research lab, LaPlaca will work with an undergraduate research class called Concussion Connect, which is part of the Vertically Integrated Projects program at Georgia Tech.

“Through the PTC, Georgia Tech and Children’s will positively impact brain health in Georgia’s pediatric population,” said LaPlaca.

Yeo is the Harris Saunders, Jr. Professor in the George W. Woodruff School of Mechanical Engineering and the director of the Wearable Intelligent Systems and Healthcare Center at Georgia Tech. His research focuses on nanomanufacturing and membrane electronics to develop soft biomedical devices aimed at improving disease diagnostics, therapeutics, and rehabilitation.

“I am truly honored to be awarded the Peterson Professorship from the Children’s PTC at Georgia Tech,” he said. “This recognition will greatly enhance my research efforts in developing soft bioelectronics aimed at advancing pediatric healthcare, as well as expand education opportunities for the next generation of undergraduate and graduate students interested in creating innovative medical devices that align seamlessly with the recent NSF Research Traineeship grant I received. I am eager to contribute to the dynamic partnership between Georgia Tech and Children’s Healthcare of Atlanta and to empower innovative solutions that will improve the lives of children.”

The Peterson Professorships honor the former Georgia Tech President and First Lady, whose vision for the importance of research in improving pediatric healthcare has had an enormous positive impact on the care of pediatric patients in our state and region.

The Children’s PTC at Georgia Tech brings clinical experts from Children’s together with Georgia Tech scientists and engineers to develop technological solutions to problems in the health and care of children. Children’s PTC provides extraordinary opportunities for interdisciplinary collaboration in pediatrics, creating breakthrough discoveries that often can only be found at the intersection of multiple disciplines. These collaborations also allow us to bring discoveries to the clinic and the bedside, thereby enhancing the lives of children and young adults. The mission of the PTC is to establish the world’s leading program in the development of technological solutions for children’s health, focused on three strategic areas that will have a lasting impact on Georgia’s kids and beyond.

Micro-brain sensors placed between hair strands overcome traditional brain sensor limitations.

Georgia Tech researchers have developed an almost imperceptible microstructure brain sensor to be inserted into the minuscule spaces between hair follicles and slightly under the skin. The sensor offers high-fidelity signals and makes the continuous use of brain-computer interfaces (BCI) in everyday life possible.

BCIs create a direct communication pathway between the brain's electrical activity and external devices such as electroencephalography devices, computers, robotic limbs, and other brain monitoring devices. Brain signals are commonly captured non-invasively with electrodes mounted on the surface of the human scalp using conductive electrode gel for optimum impedance and data quality. More invasive signal capture methods such as brain implants are possible, but this research seeks to create sensors that are both easily placed and reliably manufactured. 

Hong Yeo, the Harris Saunders Jr. Professor in the George W. Woodruff School of Mechanical Engineering, combined the latest microneedle technology with his deep expertise in wearable sensor technology that may allow stable brain signal detection over long periods and easy insertion of a new painless, wearable microneedle BCI wireless sensor that fits between hair follicles. The skin placement and extremely small size of this new wireless brain interface could offer a variety of benefits over traditional gel or dry electrodes.

“I started this research because my main goal is to develop new sensor technology to support healthcare and I had previous experience with brain-computer interfaces and flexible scalp electronics,” said Yeo, who is also a faculty member in Georgia Tech’s Institute for People and Technology. “I knew we needed better BCI sensor technology and discovered that if we can slightly penetrate the skin and avoid hair by miniaturizing the sensor, we can dramatically increase the signal quality by getting closer to the source of the signals and reduce unwanted noise.”

Today’s BCI systems consist of bulky electronics and rigid sensors that prevent the interfaces from being useful while the user is in motion during regular activities. Yeo and colleagues constructed a micro-scale sensor for neural signal capture that can be easily worn during daily activities, unlocking new potential for BCI devices. His technology uses conductive polymer microneedles to capture electrical signals and conveys those signals along flexible polyimide/copper wires — all of which are packaged in a space of less than 1  millimeter.

A study of six people using the device to control an augmented reality (AR) video call found that high-fidelity neural signal capture persisted for up to 12 hours with very low electrical resistance at the contact between skin and sensor. Participants could stand, walk, and run for most of the daytime hours while the brain-computer interface successfully recorded and classified neural signals indicating which visual stimulus the user focused on with 96.4% accuracy. During the testing, participants could look up phone contacts and initiate and accept AR video calls hands-free as this new micro-sized brain sensor was picking up visual stimuli — all the while giving the user complete freedom of movement.  

According to Yeo, the results suggest that this wearable BCI system may allow for practical and continuous interface activity, potentially leading to everyday use of machine-human integrative technology.

“I firmly believe in the power of collaboration, as many of today’s challenges are too complex for any one individual to solve,” said Yeo. “Therefore, I would like to express my gratitude to all the researchers in my group and the amazing collaborators who made this work possible. I will continue collaborating with the team to enhance BCI technology for rehabilitation and prosthetics.”

Note: Hodam Kim (postdoctoral research fellow), Ju Hyeon Kim (visiting Ph.D. student from Inha University – South Korea), and Yoon Jae Lee (Ph.D. student) also played a major role in developing this technology.

Funding: National Science Foundation NRT (Research Traineeship program in the Sustainable Development of Smart Medical Devices), WISH Center (Institute for Matter and Systems), and partial research support from several South Korean programs and grants.

PNAS article publication (April 7, 2025, Vol. 122, No. 15): https://www.pnas.org/doi/10.1073/pnas.2419304122