Associate Director, Parker H. Petit Institute for Bioengineering and Bioscience
Regents’ Professor of Chemistry & Biochemistry
Director, NSF Center for Chemical Evolution
Petit Biotechnology Building, Office 1108
Georgia Institute of Technology
Intercalation-mediated Nucleic Acid Assembly, The Molecular Midwife & the Origin of Life, Nucleic Acid-Cation Interactions, Understanding DNA & RNA Condensation. The research in our laboratory is directed towards elucidating the fundamental chemical and physical principles that govern nucleic acid (RNA and DNA) assembly. We are interested in how the physical properties of nucleic acids govern biological functions in contemporary life, and how these same properties provide clues to the origin and early evolution of life. We are also applying our knowledge of nucleic acids to problems that are of current importance in medicine and biotechnology. Specific projects include investigations of: 1) the origin and evolution of RNA; 2) cation, solvent and small molecule interactions with nucleic acids; 3) nucleic acid condensation and packaging; and 4) folding and evolution of the ribosome. Our research involves the application of a wide variety of physical and chemical techniques.
Research Affiliations: Center for Drug Design Development & Delivery, Center for Chemical Evolution, Center for Nanobiology of the Macromolecular Assembly Disorders - NanoMAD