Luke Brewster
Assistant Professor, Division of Vascular Surgery
Program Faculty, Bioengineering Program, Georgia Institute of Technology
Program Faculty, Georgia Institute of Technology and Emory Biomedical Engineering Program
Dr. Brewster's clinical practice is focused on general vascular surgery and peripheral arterial disease, and his affiliations include Emory University Hospital and serving as section chief of vascular surgery at the Atlanta VA Healthcare System.
As a surgeon-scientist, his joint affiliations with the Atlanta Clinical and Translational Science Institute and the Wallace Coulter Department of Biomedical Engineering at Georgia Tech/Emory have given him access to an exceptional pool of collaborators, and he has received a steady stream of various federal, foundation, and industry grants.
Dr. Brewster's laboratory focuses on investigations of the biomechanical mechanisms that contribute to pathologic vessel remodeling in peripheral vascular disease, develops regenerative strategies for use in ischemic tissue, and works to improve the function of patients who succumb to major amputation.
404-727-8329
Office Location:
Emory WMRB 5211
- Molecular, Cellular and Tissue Biomechanics
The Brewster Laboratory is interested in determining the effect of altered biomechanics and extracellular matrix formation during arterial remodeling after vascular intervention in stiffened and diseased arteries. Using animal models and human arterial tissue, I quantify the in and ex vivo contribution of the cellular and extracellular matrix to biomechanical forces of the artery in stiffened and healthy states. In turn these forces manipulate the cellular and extracellular matrix composition of these arteries during remodeling, and this response is different in stiffened arteries, which are commonly encountered clinically. Thus understanding of this pathologic remodeling in model and human tissue is novel and critical to the development of intelligent therapeutics.
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