Robert A. Milton Endowed Chair; Coulter Department of Biomedical Engineering
Director, NSF Engineering Research Center (ERC) for Cell Manufacturing Technologies (CMaT)
Director, Center for ImmunoEngineering @ Georgia Tech
Director, Marcus Center for Therapeutic Cell Characterization & Manufacturing
Our overall research interests are in developing novel concepts for stem cell engineering as well as polymer controlled delivery of biological factors, especially for nucleic acid therapeutics (DNA, SiRNA and oligos) and immunoengineering. Currently, my group is involved in the following major areas of research; (a) Developing novel concepts to produce biodegradable surface functionalized micro-and nanoparticles for targeted and sustained delivery of nucleic acids, proteins, peptides and other immune modulators. In particular we are interested in developing multi-agent vaccine delivery systems for cancer and infectious diseases as well as immunotherapies for autoimmune diseases. (b) Creating spatio-temporally patterned polymer scaffolds for directed compartmental differentiation of stem cells into multiple lineages. (c) Engineering an artificial thymic niche for directed differentiation of stem cells into functional, antigen- specific T cells. (e) The development of novel nanoimprinting techniques to generate shape specific, environmentally triggered drug nanocarriers.
Georgia Institute of Technology
The overall goal of our research endeavor is the development of new biomaterial-based strategies for gene/drug delivery and stem cell engineering. Towards this, my laboratory focuses on three major directions: (a) design and development of novel delivery systems for nucleic-acid based immunotherapy and cancer chemotherapy (b) engineering complex microenvironments to study and manipulate stem cells and understand their behavior in biomimetic, three-dimensional conditions and (c) developing novel engineering tools and high throughput methods to generate functional T cells and Dendritic cells from stem cells.
Research Affiliations: Marcus Center for Therapeutic Cell Characterization and Manufacturing (MC3M), Regenerative Engineering and Medicine (REM), Immunoengineering, Center for ImmunoEngineering, Center for Drug Design Development & Delivery, Biomaterials, Center for Pediatric Innovation (CPI)