Cheng Zhu

J. Erskine Love Jr. Endowed Chair in Engineering
Regents' Professor
Executive Director, International Programs


Office Location:
UAW 1210


Related Site


Google Scholar

Georgia Institute of Technology

College of Engineering
Wallace H. Coulter Department of Biomedical Engineering
Research Focus Areas:
  • Biobased Materials
  • Molecular, Cellular and Tissue Biomechanics
  • Additional Research:
    Biomechanics; Cell biophysics; Bioinformatics; Electron Microscopy. Biomechanics and mechanobiology of cell adhesion and signaling molecules of the immune system and the vascular systems: Our interests lie in the adhesion and signaling molecules of the immune system as well as those involved in platelet adhesion and aggregation. We are primarily focused on early cell surface interaction kinetics and their primary signaling responses, as these are critical in determining how a cell will ultIMaTely respond upon contact with another cell. The majority of our work ranges from single molecule interaction studies using atomic force microscopy, molecular dynamics simulations, or biomembrane force probe assays to single cell studies using micropipette adhesions assays, fluorescence imaging techniques, or real-time confocal microscopy. These assays focus on the mechanics and kinetics of receptor-ligand binding and their downstream signaling effects within cells. T cell receptors, selectins, integrins, and their respective ligands are some of the cell surface molecules currently under investigation in our lab. Understanding the initial interaction between molecules such as these and their subsequent early signaling processes is crucial to elucidating the response mechanisms of these physiological systems. UltIMaTely, our research strives to help better understand the mechanisms within these systems for possible medical applications in autoimmunity, allergy, transplant rejection, and thrombotic disorders.

    Research Affiliations: Regenerative Engineering and Medicine (REM), Integrated Cancer Research Center, Immunoengineering, Center for ImmunoEngineering

    IRI Connection: