Three Postdoc Positions available in Immune-Tissue Interactions in Physiomimetic Systems

Three postdoc positions are available in the Biological Engineering Department at MIT, for experimental and computational approaches to “immune chips”, in areas ranging from microfluidic device implementation to tissue engineering of immune models to systems immunology of immune-tissue- (microbe) interactions. These are related to two related projects led by Prof. Linda Griffith, in collaboration with Prof. Doug Lauffenburger (Biol. Eng./ Ragon institute)), Prof. Bryan Bryson (Biol. Eng. / Ragon Institute), Prof. David Trumper (Mechanical Eng) and Prof. Roger Kamm (Biol. Eng)., and include applications in endometriosis, Lyme disease, and Type 2 diabetes.

Interested candidates should send a cv, statement of research and career interests, and list of 3 references to Prof. Linda Griffith.

  1. Microfluidic platforms for analyzing sexually dimorphic immune-mediated changes in microvascular permeability. This postdoctoral position spans the Griffith, Trumper and Kamm labs and focuses on translating advanced microfluidic models developed for microvascularized endometriosis lesions into practice with a team of tissue engineers and biologists, including incorporation of imaging modes and translation to mucosal barrier models. Applications in addition to endometriosis include infectious disease (Lyme), gut, and liver models. A strong background in mechanical engineering device design and implementation, including theoretical and conceptual understanding of microfluidic principles in addition to experimental implementation, is desired. Familiarity with imaging of biological tissues, and biological applications of microfluidic devices, is desired but not required. Demonstrated accomplishments in engineering design and fabrication are essential; candidates with experience solely in computational modeling are will not be considered, as the project requires extensive hands-on iterative experimentation in collaboration with biologists.
  2. Engineering immune-tissue interactions in Lyme disease. This postdoctoral position spans the Griffith, Bryson, and Lauffenburger labs and focuses on building 3D models of innate immune system – tissue interactions in models of acute and chronic Lyme infection, and evaluating the effects of sexual dimorphism and other factors in responses. This project builds on a strong foundation of 3D tissue engineering using synthetic biomaterials developed in the Griffith lab, and integrates systems immunology approaches from the Bryson lab with experimental design and data interpretation approaches from the Lauffenburger lab. The ideal candidate will have a background in immunology / cell biology with either experience in or interest in tissue engineering. Extension to additional immune system components is encouraged, but innate responses are the initial emphasis of the project.
  3. Computational analysis of immune-tissue-microbe interactions in Lyme disease. This postdoctoral position is centered in the Lauffenburger lab and focuses on experimental design and analysis of systems serology data from Lyme disease patients, in collaboration with the lab of Galit Alter at the Ragon Institute/MGH. The project also includes design and interpretation of in vitro models of infection, in collaboration with the Bryson and Griffith labs.

Email: Professor Linda Griffith

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